기본 정보
- 표준 SMILES
CC(C)(C)NC[C@H](O)COc1cccc2c1CCCC2=O.Cl- InChIKey
DNTDOBSIBZKFCP-YDALLXLXSA-N- 분자식
- C17H26ClNO3
- 평균 분자량
- 327.8 g/mol
- 단동위원소 질량
- 327.16012137
개요
Levobunolol hydrochloride is a hydrochloride obtained by combining equimolar amounts of levobunolol and hydrochloric acid. A non-selective beta-adrenergic antagonist used for treatment of glaucoma. It has a role as a beta-adrenergic antagonist and an antiglaucoma drug. It contains a levobunolol(1+).
이름 및 식별자
- 우선 이름
- Levobunolol Hydrochloride
- IUPAC
- 5-[(2S)-3-(tert-butylamino)-2-hydroxypropoxy]-3,4-dihydro-2H-naphthalen-1-one;hydrochloride
이름 및 동의어
levobunolol hydrochloride27912-14-7Levobunolol HClAkbetaBetaganDTXSID6020777W 7000ANSC-759158W-7000AO90S49LDHHDTXCID20777CHEBI:6439
이름 더 보기
(-)-3,4-Dihydro-5-(3-(tert-butylamino)-2-hydroxypropoxy)-1(2H)-naphthalenone hydrochlorideRefChem:55472W7000A248-725-3Levobunolol (hydrochloride)Levobunolol.HClGotensin(-) -Levobunolol hydrochloride
데이터베이스 식별자
- CAS
27912-14-7- PubChem CID
- 5284409
- DTXSID
DTXSID6020777- ChEMBL
CHEMBL1201177- ChEBI
CHEBI:6439- UNII
- O90S49LDHH
- EC Number
- 248-725-3
물성
구조 계산 물성
- 극성 표면적
- 58.6 Ų
- 수소 결합 공여자 수
- 3
- 수소 결합 수용자 수
- 4
- 회전 가능 결합 수
- 6
- 무거운 원자 수
- 22
- 형식 전하
- 0
- 복잡도
- 350
실험 및 물리화학적 성질
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
안전 및 규제
GHS 분류
GHS Classification
This chemical does not meet GHS hazard criteria for 2.1% (1 of 48) of reports.
Warning
H302 (97.9%): Harmful if swallowed [Warning Acute toxicity, oral]
P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 48 reports by companies from 3 notifications to the ECHA C&L Inventory.
유해성 정보
Hazard Classes and CategoriesAcute Tox. 4 (97.9%)
화학 및 산업
약리 정보
FDA Pharmacological Classification
LEVOBUNOLOL HYDROCHLORIDE
beta-Adrenergic Blocker [EPC]; Adrenergic beta-Antagonists [MoA]
MeSH Pharmacological Classification
Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.
Drugs that inhibit the actions of the sympathetic nervous system by any mechanism. The most common of these are the ADRENERGIC ANTAGONISTS and drugs that deplete norepinephrine or reduce the release of transmitters from adrenergic postganglionic terminals (see ADRENERGIC AGENTS). Drugs that act in the central nervous system to reduce sympathetic activity (e.g., centrally acting alpha-2 adrenergic agonists, see ADRENERGIC ALPHA-AGONISTS) are included here.
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1건
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