Triprolidine hydrochloride monohydrate
TRIPROLIDINE HCL MONOHYDRATE · rate,stereoisomer · TRIPROLIDINE HCL USP · trans-TriprolidineHCl · Tripolidine Hydrochloride · Triprolidine hydrochloride · Triprolidine Hydrochlorise · TRIPROLIDINEHYDROCHLORIDE,USP
식별자 및 물리적 특성
| CAS No. | 6138-79-0 |
|---|---|
| 분자식 | C19H22N2.ClH.H2O |
| 평균 분자량 | 332.9 g/mol |
| 단동위원소 질량 | 332.1655411 g/mol |
| SMILES | Cc1ccc(/C(=C\CN2CCCC2)c2ccccn2)cc1.Cl.O |
| InChIKey | CUZMOIXUFHOLLN-UMVVUDSKSA-N |
| PubChem CID | 5284472 |
| ChEMBL | CHEMBL3188034 |
| ChEBI | CHEBI:32265 |
| EC No. | 627-740-2 |
| DTXSID | DTXSID0021410 |
화학 및 물리적 성질
| 극성 표면적 | 17.1 |
|---|---|
| 수소 결합 공여자 수 | 2 |
| 수소 결합 수용자 수 | 3 |
| 회전 가능 결합 수 | 4 |
| 무거운 원자 수 | 23 |
| 형식 전하 | 0 |
| 복잡도 | 335 |
| 용해도 | greater than or equal to 100 mg/mL at 68 °F (NTP, 1992)알코올: 용매 1.5에 용해1 |
| 녹는점 | 239 to 248 °F (NTP, 1992)115-120°C |
| Physical Description | Triprolidine hydrochloride monohydrate is an odorless white crystalline powder. Bitter taste. (NTP, 1992) |
| 저장 조건 | 2-8°C |
| 물리적 상태 | Solid |
| 색상 | 흰색에서 황백색까지 |
| 용해도 | 20°C에서 >=10g/100mL |
| Merck | 13,9817 |
| 안정성 | 안정적이지만 빛에 변색됩니다. 강한 산화제와 호환되지 않습니다. |
| InChI | InChI=1S/C19H22N2.ClH/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21/h2-3,6-12H,4-5,13-15H2,1H31H/b18-11+ |
| InChIKey | WYUYEJNGHIOFOC-NWBUNABESA-N |
| SMILES | C(=C/CN1CCCC1)(\C1=NC=CC=C1)/C1C=CC(C)=CC=1.Cl |
| LogP(분배 계수) | 4.223 (est) |
| EPA | Pyridine, 2-[1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl]-, monohydrochloride, monohydrate, (E)- (6138-79-0) |
화학적 성질
TRIPROLIDINE HYDROCHLORIDE is a white, crystalline powder.
안전 및 규제
| GHS 분류 | WarningH302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 96 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| 규제 정보 | Pyridine, 2-(1E)-1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl-, monohydrochloride, monohydrate: Does not have an individual approval but may be used under an appropriate group standard |
| 기타 안전 정보 | IMAP assessments - Pyridine, 2-[1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl]-, monohydrochloride, monohydrate, (E)-: Environment tier I assessment |
| 화재 위험 | Flash point data for this chemical are not availablehowever, it is probably combustible. (NTP, 1992) |
| 건강 유해성 | SYMPTOMS: Symptoms of exposure to this compound may include depression to stimulation of the central nervous system, dry mouth, fixed dilated pupils, flushing, hallucinations, convulsions, urinary retention, cardiac arrhythmias and coma. Other symptoms may include excitability, drowsiness, nervousness, dizziness, high fever and sleeplessness. It can also cause sedation. It may also cause local anesthesia, dryness of the throat and nose and abdominal pain with vomiting or diarrhea. (NTP, 1992) |
| 반응성 그룹 | Amines, Phosphines, and Pyridines |
| Reactivity Profile | TRIPROLIDINE HYDROCHLORIDE MONOHYDRATE discolors on exposure to light. It is an acidic salt and can neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible. Many of these compounds catalyze organic reactions. |
| Air and Water Reactions | Water soluble. |
| Hazard Classes and Categories | Acute Tox. 4 (100%) |
| 소화 | Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992) |
용도
용도
TRIPROLIDINE HYDROCHLORIDE is used as bulk pharmaceutical (antihistaminic). Product Data Sheet
일반 설명
Triprolidine hydrochloride,(E)-2-[3-(1-pyrrolidinyl)-1-p-tolylpropenyl]pyridine monohydrochloridemonohydrate (Actidil), is a white crystalline powder with a slight, but unpleasant, odor. It is soluble inwater and in alcohol, and its solutions are alkaline to litmus.The antihistaminic activity is confined mainly to the geometricisomer in which the pyrrolidinomethyl group is transto the 2-pyridyl group. Pharmacological studies confirm thehigh activity of triprolidine and the superiority of (E) overcorresponding (Z) isomers as H1-antihistamines. At guineapig ileum sites, the affinity of triprolidine for H-receptorswas more than 1,000 times the affinity of its (Z) diasteromer.The relative potency of triprolidine is of the same orderas that of dexchlorpheniramine. The peak effect occursabout 3.5 hours after oral administration, and the duration ofeffect is about 12 hours.