기본 정보
- CAS
2124-57-4- 표준 SMILES
CC(C)=CCC/C(C)=C/CC/C(C)=C/CC/C(C)=C/CC/C(C)=C/CC/C(C)=C/CC/C(C)=C/CC1=C(C)C(=O)c2ccccc2C1=O- InChIKey
RAKQPZMEYJZGPI-LJWNYQGCSA-N- 분자식
- C46H64O2
- 평균 분자량
- 649 g/mol
- 단동위원소 질량
- 648.49063128
개요
Menaquinone-7 is a menaquinone whose side-chain contains seven isoprene units in an all-trans-configutation. It has a role as a Mycoplasma genitalium metabolite, a cofactor, a bone density conservation agent, an Escherichia coli metabolite and a human blood serum metabolite.
이름 및 식별자
- 우선 이름
- Menaquinone 7
- IUPAC
- 2-[(2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyloctacosa-2,6,10,14,18,22,26-heptaenyl]-3-methylnaphthalene-1,4-dione
- 현지명
- 비타민K2(35)
- 영어명
- Menaquinone 7
- 분자식
- C46H64O2
- 분자량
- 649
이름 및 동의어
Menaquinone-7Menaquinone 72124-57-4Vitamin K2(35)Menaquinone K7Vitamin MK 7Menakinon 72-((2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-Heptamethyloctacosa-2,6,10,14,18,22,26-heptaen-1-yl)-3-methylnaphthalene-1,4-dione8427BML8NY1,4-Naphthalenedione, 2-(3,7,11,15,19,23,27-heptamethyl-2,6,10,14,18,22,26-octacosaheptaenyl)-3-methyl-, (all-E)-2-[(2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyloctacosa-2,6,10,14,18,22,26-heptaenyl]-3-methylnaphthalene-1,4-dione2-[(2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyloctacosa-2,6,10,14,18,22,26-heptaen-1-yl]-3-methylnaphthalene-1,4-dione
이름 더 보기
비타민K2(35)Menlaquinone 7Menaquinone 7, Synthetic (90%)Menaquinone-7(MK-7)Menatetrenone (MK-7)
CHEBI:44245DTXSID8013174742-((2E,6E,10E,14E,18E,22E)-3,7,11,15,19,23,27-heptamethyloctacosa-2,6,10,14,18,22,26-heptaenyl)-3-methylnaphthalene-1,4-dioneRefChem:925473DTXCID90908566Vitamin K2-7MK-7Menaquinone 7, Synthetic
데이터베이스 식별자
- CAS
2124-57-4- PubChem CID
- 5287554
- DTXSID
DTXSID801317474- ChEMBL
CHEMBL1230575- ChEBI
CHEBI:44245- UNII
- 8427BML8NY
- EC Number
- 870-176-9
- Nikkaji
- J141.747I、J16.269H
물성
구조 계산 물성
- XLogP
- 14.5
- 극성 표면적
- 34.1 Ų
- 수소 결합 공여자 수
- 0
- 수소 결합 수용자 수
- 2
- 회전 가능 결합 수
- 20
- 무거운 원자 수
- 48
- 형식 전하
- 0
- 복잡도
- 1,310
실험 및 물리화학적 성질
Chemical ClassesBiological Agents -> Vitamins and Derivatives
DrugsPharmaceuticals -> Listed in ZINC15
LipidsLipids -> Prenol Lipids [PR] -> Quinones and hydroquinones [PR02] -> Vitamin K [PR0203]
Physical DescriptionLight yellow solid; [Merck Index]
물리화학적 성질
- 녹는점
- 54 °C · 54 °C
- 끓는 점
- 0.0002 · bp0.0002 200° (some dec)
- 밀도
- 0.961 · 0.961
- 저장 조건
- -20 °C · -20°C
- 용해도
- 클로로포름(약간 용해됨), 에틸아세테이트(약간 용해됨), 메탄올(약간 용해됨)
- 물리적 상태
- 고체
- 색상
- 연한 노란색에서 노란색까지
- 안정성
- 빛과 온도에 민감함
- 주요 응용
- 임상 시험임상 시험
- 화장품 원료 기능
- 자외선 필터피부 보호피부의 멜라닌 생성을 줄입니다피지 억제수렴제
- InChIKey
- RAKQPZMEYJZGPI-LJWNYQGCSA-N
- SMILES
- C1(=O)C2=C(C=CC=C2)C(=O)C(C)=C1C/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC/C=C(/C)\C
- LogP
- 14.451 · 14.451 (est)
화학적 성질
Light Yellow Crystalline Solid
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
This chemical does not meet GHS hazard criteria for 100% (105 of 105) of all reports.
Not Classified
Aggregated GHS information provided per 105 reports by companies from 1 notifications to the ECHA C&L Inventory.
유해성 정보
Hazard Classes and CategoriesNot Classified
안전 데이터
- wgk
- WGK 2
- HS 번호
- 2936299055
- Hazard Classifications
- Acute Tox. 4 DermalAcute Tox. 4 InhalationAcute Tox. 4 OralEye Irrit. 2Flam. Liq. 2
- 스토리지 클래스
- 3 - Flammable liquids
- 유해 물질 데이터
- 2124-57-4(Hazardous Substances Data)
화학 및 산업
약리 정보
MeSH Pharmacological Classification
Agents acting to arrest the flow of blood. Absorbable hemostatics arrest bleeding either by the formation of an artificial clot or by providing a mechanical matrix that facilitates clotting when applied directly to the bleeding surface. These agents function more at the capillary level and are not effective at stemming arterial or venous bleeding under any significant intravascular pressure.
용도 및 제조
UsesMenaquinones (vitamin K2) have vitamin K activity; Produced by intestinal bacteria and used as a vitamin (prothrombogenic); [Merck Index]
응용 분야
개요Menaquinone 7 (MK-7) is a vitamin K2 analog that has been found in a variety of fermented foods. It increases osteocalcin, osteoprotegerin, and RANKL mRNA expression in osteoblastic MC3T3E cells. MK-7 (1 μM) increases alkaline phosphatase activity and calcium content in femoral-metaphyseal tissues isolated from normal and skeletal-unloaded rats. In vivo, MK-7 (100 μg/g diet) inhibits aortic and myocardial calcification and decreases aortic alkaline phosphatase tissue concentrations in a rat model of extraosseous calcification. It also increases trabecular number, bone mineral density, and bone mineral content in a rat model of ovariectomy-induced bone loss.
용도Vitamin (prothrombogenic)
일반 설명Vitamin K2, also known as menaquinone, is a polyisoprenoid-substitutednapthoquinone. Menaquinone-7 (MK-7) is a subtype of vitamin K2. It is found in animals, soy protein, fermented products and is primarily produced by bacteria.Vitamin K2 (MK-7)-(5,6,7,8-d4,2-methyl-d3) is a deuterated vitamin K2 wherein C-5, C-6, C-7, C-8, and 2-methyl protons are replaced by deuterium.
상·하류 제품 정보
상류 원료
공급사100 곳
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추가 설명
정의ChEBI: A menaquinone whose side-chain contains seven isoprene units in an all-trans-configutation.
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