기본 정보
- CAS
57-24-9- 표준 SMILES
O=C1CC2OCC=C3CN4CCC56c7ccccc7N1C5C2C3CC46- InChIKey
QMGVPVSNSZLJIA-UHFFFAOYSA-N- 분자식
- C21H22N2O2
- 평균 분자량
- 334.4 g/mol
- 단동위원소 질량
- 334.16812795
개요
strychnidine-14-one (unspec. stereochem.) has been reported in Strychnos nux-vomica with data available.
이름 및 식별자
- 우선 이름
- Strychnin
- IUPAC
- 4a,5,5a,7,8,13a,15,15a,15b,16-decahydro-2H-4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinolin-14-one
- 현지명
- 스트리치닌
- 영어명
- STRYCHNINE
- 분자식
- C21H22N2O2
- 분자량
- 334.41
이름 및 동의어
Strychnin4a,5,5a,7,8,13a,15,15a,15b,16-decahydro-2H-4,6-methanoindolo(3,2,1-ij)oxepino(2,3,4-de)pyrrolo(2,3-h)quinolin-14-one4a,5,5a,7,8,13a,15,15a,15b,16-decahydro-2H-4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinolin-14-oneRefChem:1099105NSC5365VauqulineNSC 5365CHEMBL1609139SCHEMBL29362678QMGVPVSNSZLJIA-UHFFFAOYSA-NMFCD00005941STL372869
이름 더 보기
스트리키닌스트리치닌스트리키닌및그염류스트리크닌스트라이크닌스트라이크딘-10-온스트리시닌스트리시닌 염류스트리키니딘-10-온(-)-STRYCHNINEnuxvomicastrychineStrychnidin-10-oneCertoxKwik-Kilhare-ridSanaseedmoledeath
AKOS025247982UN 1692NCGC00167847-01VS-12360DB-050083WLN: T6 G656 B7 C6 E5 D 5ABCEF A& FX MNV QO VN SU AHT&&TTTTJ12-oxa-8,17-diazaheptacyclo[15.5.2.0(1),(1)?.0(2),?.0?,(2)(2).0(1)(1),(2)(1).0(1)?,(2)?]tetracosa-2(7),3,5,14-tetraen-9-one
물성
구조 계산 물성
- XLogP
- 1.9
- 극성 표면적
- 32.8 Ų
- 수소 결합 공여자 수
- 0
- 수소 결합 수용자 수
- 3
- 회전 가능 결합 수
- 0
- 무거운 원자 수
- 25
- 형식 전하
- 0
- 복잡도
- 689
물리화학적 성질
- 녹는점
- 284 · 284-286 °C(lit.)
- 끓는 점
- 471.21 °C · 471.21°C (rough estimate)
- 밀도
- 18 · d18 1.359
- 증기압
- 1.5 xl0-7 · 1.5 xl0-7 Pa (20 °C, est.)
- 굴절률
- 1.65 · 1.6500 (estimate)
- 저장 조건
- Poison room
- 용해도
- 클로로포름: 투명하거나 흐릿함
- 산도 계수 (pKa)
- 8.26 · 8.26(at 25℃)
- 수용성
- 143 mgl-1 · 143mgl-1
- 물리적 상태
- 미세 결정성 분말
- 색상
- 하얀색
- 냄새
- Odorless
- Merck
- 14 · 14,8855
- Henry's Law Constant
- 1.6 · 1.6×108 mol/(m3Pa) at 25℃, HSDB (2015)
- 안정성
- 안정적인. 강한 산화제와 호환되지 않습니다.
- LogP
- 1.93 · 1.930
- EPA
- Strychnine (57-24-9)
화학적 성질
Strychnine is a colorless crystalline prisms or white powder. It is odorless; with a bitter taste
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
독성 정보
Treatment
Treatment of strychnine poisoning involves an oral application of an activated charcoal infusion to absorb any poison within the digestive tract that has not yet been absorbed into the blood. Anticonvulsants such as phenobarbital or diazepam are administered to control convulsions, along with muscle relaxants such as dantrolene to combat muscle rigidity. (L1228)
Health EffectsDeath may result from asphyxia or sheer exhaustion. (L1230)
Exposure RoutesOral (ingestion) (L1817) ; dermal (L1817)
Toxicity SummaryStrychnine acts as an antagonist at the inhibitory or strychnine-sensitive glycine receptor, a ligand-gated chloride channel in the spinal cord and the brain. (L1230)
Signs and SymptomsStrychnine causes muscular convulsions of increasing intensity and frequency and eventually death through asphyxia or sheer exhaustion. (L1230)
Carcinogen ClassificationNo indication of carcinogenicity to humans (not listed by IARC).
Toxicity DataLD50: 2350 ug/kg (Oral, Rat) (T14)
LD50: 1100 ug/kg (Intraperitoneal, Rat) (T14)
LD50: 1200 ug/kg (Subcutaneous, Rat) (T14)
LD50: 582 ug/kg (Intravenous, Rat) (T14)
안전 데이터
- OEB
- C
- OEL
- TWA: 0.15 mg/m3
- wgk
- 3
- IDLA
- 3 mg/m3
- tsca
- TSCA listed
- rtecs
- WL2275000
- ridadr
- UN 1692 (STRYCHNINE or STRYCHNINE SALTS)
화학 및 산업
용도 및 제조
UsesStrychnine is a plant toxin most commonly found in the seeds of the Strychnine tree (Strychnos nux-vomica L.). It is used as a pesticide, particularly for killing small vertebrates such as birds and rodents. (L1230)
응용 분야
개요Strychnine, C21H22N2O2, Mr 334.4, mp 270–280 C (decomp.), forms colorless crystals which are slightly soluble in water, moderately in benzene, ethanol, readily soluble in chloroform [9, p. 1121].
용도Strychnine occurs in the seeds of strychnosspecies (S. nux vomica L., S. Loganiaceae,and S. ignatii Berg). The total alkaloid con tent in these plants is 2–3%. The composition of strychnine in these species rangesbetween 1% and 3%. Strychnine is widelyknown as a poison. Its therapeutic applica tions are very limited. It is used as a rodentpoison.
일반 설명Colorless, transparent crystals or white crystalline powder. Has no odor. Used for destroying rodents and predatory animals and for trapping fur-bearing animals.
제조 방법
생산 방법Strychnine is extracted from Strychnos nux-vomica seeds. The very complex chemical synthesis has been achieved by WOODWARD et al. (74).
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