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기본 정보
- CAS
405098-33-1- 표준 SMILES
COc1ccc2c(c1)C(C(=O)N(Cc1ccc(N(C)C)cc1)c1ccc(C(C)C)cc1)CCC2.Cl- InChIKey
UKBJWRMNGCDKNL-UHFFFAOYSA-N- 분자식
- C30H37ClN2O2
- 평균 분자량
- 493.091 g/mol
- 단동위원소 질량
- 492.2543561
이름 및 식별자
- 우선 이름
- C5a Receptor Antagonist, W-54011
- IUPAC
- N-{[4-(Dimethylamino)phenyl]methyl}-7-methoxy-N-[4-(propan-2-yl)phenyl]-1,2,3,4-tetrahydronaphthalene-1-carboxamide--hydrogen chloride (1/1)
- 영어명
- N-[[4-(Dimethylamino)phenyl]methyl]-1,2,3,4-tetrahydro-7-methoxy-N-[4-(1-methylethyl)phenyl]-1-naphthalenecarboxamide hydrochloride
- 분자식
- C30H36N2O2.ClH
- 분자량
- 493.08
이름 및 동의어
W-54011CS-2062W-54011, 10 mM in DMSOC5a Receptor Antagonist, W-54011N-{[4-(diMethylaMino)phenyl]Methyl}-7-Methoxy-N-[4-(propan-2-yl)phenyl]-1,2,3,4-tetrahydronaphthalene-1-carboxaMide hydrochlorideN-[[4-(Dimethylamino)phenyl]methyl]-1,2,3,4-tetrahydro-7-methoxy-N-[4-(1-methylethyl)phenyl]-1-naphthalenecarboxamide hydrochloridechemotaxis,inhibit,orally,W-54011,mobilization,anaphylatoxin,ROS,Reactive Oxygen Species,Ca2+,C5a,neutrophils,Inhibitor,Complement System,W54011,inflammatory,W 54011
데이터베이스 식별자
- CAS
405098-33-1- PubChem CID
- 5311121
- DTXSID
DTXSID50415509- ChEMBL
CHEMBL5092226- ChEBI
CHEBI:197423
물성
물리화학적 성질
- 저장 조건
- -20 °C · Store at -20°C
- 용해도
- 30 mg/mL; · DMF: 30 mg/mL; DMSO: 30 mg/mL; Ethanol: 3 mg/mL
- 물리적 상태
- 백색 분말 고체.
- 색상
- White to light yellow
- 안정성
- 흡습성
화학 및 산업
응용 분야
개요W-54011 is an orally bioavailable, nonpeptide antagonist of complement component 5a receptor 1 (C5aR), also known as cluster of differentiation 88 (CD88). W-54011 inhibits 125I-rhC5a binding in neutrophils (Ki = 2.2 nM) and C5a-mediated intracellular Ca2+ mobilization (IC50 = 3.1 nM). W-54011 is selective and does not affect Ca2+ mobilization mediated by other G protein-coupled receptor (GPCR) ligands, N-Formyl-Met-Leu-Phe (fMLF; ), or IL-8 up to a concentration of 10 μM. It inhibits Ca2+ mobilization in neutrophils in humans, cynomolgus monkeys, and gerbils, but not in mice, rats, guinea pigs, rabbits, or dogs. At 10 nM, W-54011 also inhibits C5a-mediated migration and vessel formation of human microvascular endothelial cells (HMEC-1).
용도W 54011 is a potent orally active non-peptide C5a receptor antagonist.
공급사32 곳
陕西缔都医药有限责任公司029-81124775 17791530730 · [email protected]
成都超九八生物科技有限公司13348960310 13348960310 · [email protected]
咸宁深蓝生物医药研发有限公司18171815831 · [email protected]
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
欧利希（湖北）医药科技有限公司17316404525 17316404525 · [email protected]
United Life Science020-82099279 18988968278 · [email protected]
MedBio脉铂医药021-69568360 18916172912 · [email protected]
銳迪國際科技有限公司18024082417 · [email protected]
上海毕得医药科技股份有限公司
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