6-(2,6-Dichlorophenyl)-2-((4-(2-(diethylamino)ethoxy)phenyl)amino)-8-methylpyrido(2,3-d)pyrimidin-7(8H)-one

HCID 5311382

노트 반응

부분 구조 검색 유사 구조 찾기

기본 정보

CAS: 185039-89-8
표준 SMILES: CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)cc1
InChIKey: IFPPYSWJNWHOLQ-UHFFFAOYSA-N
분자식: C26H27Cl2N5O2
평균 분자량: 512.4 g/mol
단동위원소 질량: 511.15418046

이름 및 식별자

우선 이름: 6-(2,6-Dichlorophenyl)-2-((4-(2-(diethylamino)ethoxy)phenyl)amino)-8-methylpyrido(2,3-d)pyrimidin-7(8H)-one
IUPAC: 6-(2,6-dichlorophenyl)-2-[4-[2-(diethylamino)ethoxy]anilino]-8-methylpyrido[2,3-d]pyrimidin-7-one
영어명: PD0166285
분자식: C26H27Cl2N5O2
분자량: 512.43

이름 및 동의어

185039-89-8PD166285PD-1662856-(2,6-dichlorophenyl)-2-((4-(2-(diethylamino)ethoxy)phenyl)amino)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-oneTCMDC-140940PD-0166285F2UH9R2JT66-(2,6-Dichlorophenyl)-2-({4-[2-(Diethylamino)ethoxy]phenyl}amino)-8-Methylpyrido[2,3-D]pyrimidin-7(8h)-One6-(2,6-Dichlorophenyl)-2-((4-(2-(diethylamino)ethoxy)phenyl)amino)-8-methylpyrido(2,3-d)pyrimidin-7(8H)-one6-(2,6-dichlorophenyl)-2-((4-(2-diethylaminoethoxy)phenyl)amino)-8-methylpyrido(6,5-d)pyrimidin-7-one6-(2,6-dichlorophenyl)-2-[[4-(2-diethylaminoethoxy)phenyl]amino]-8-methylpyrido[6,5-d]pyrimidin-7-one6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylaMino)ethoxy]phenyl]aMino]-8-Methylpyrido[2,3-d]pyriMidin-7(8H)-one

이름 더 보기

PD 0166285PD0166285, 10 mM in DMSOPD-0166285,Wee1,Inhibitor,inhibit,PD 0166285,Apoptosis,PD0166285Pyrido[2,3-d]pyriMidin-7(8H)-one, 6-(2,6-dichlorophenyl)-2-[[4-[2-(diethylaMino)ethoxy]phenyl]aMino]-8-Methyl-6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one (ACI)

RefChem:1073669PD0166285CHEMBL491206-(2,6-dichlorophenyl)-2-[4-[2-(diethylamino)ethoxy]anilino]-8-methylpyrido[2,3-d]pyrimidin-7-oneC26H27Cl2N5O26-(2,6-Dichloro-phenyl)-2-[4-(2-diethylamino-ethoxy)-phenylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one6-(2,6-dichlorophenyl)-2-({4-[2-(diethylamino)ethoxy]phenyl}amino)-8-methyl-7H,8H-pyrido[2,3-d]pyrimidin-7-oneIFPPYSWJNWHOLQ-UHFFFAOYSA-N

데이터베이스 식별자

CAS: 185039-89-8
PubChem CID: 5311382
DTXSID: DTXSID501019043
ChEMBL: CHEMBL49120
UNII: F2UH9R2JT6
Nikkaji: J915.276H

물성

구조 계산 물성

XLogP: 5.6
극성 표면적: 70.6 Å²
수소 결합 공여자 수: 1
수소 결합 수용자 수: 6
회전 가능 결합 수: 9
무거운 원자 수: 35
형식 전하: 0
복잡도: 719

물리화학적 성질

끓는 점: 665.3 · 665.3±65.0 °C(Predicted)
밀도: 1.315 · 1.315±0.06 g/cm3(Predicted)
저장 조건: 2 · under inert gas (nitrogen or Argon) at 2–8 °C
용해도: 60 · DMSO:60.0(Max Conc. mg/mL);117.1(Max Conc. mM)
산도 계수 (pKa): 9.65 · 9.65±0.25(Predicted)
물리적 상태: Solid
색상: Light yellow to yellow

안전 및 규제

안전 데이터

신호 어: Warning
유해·위험 문구: 암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드 H302

화학 및 산업

응용 분야

용도PD 0166285 is a pyridopyrimidine compound that inhibits Wee1, which is a Ser/Thr kinase that regulates the cell cycle (1,2).

공급사49 곳

陕西缔都医药有限责任公司029-81124775 17791530730 · [email protected]

成都超九八生物科技有限公司13348960310 13348960310 · [email protected]

Sichuan Biosynce Pharmatech Co., Ltd.[email protected]

上海微佳禾生物科技有限公司17502176150; 17502176150 · [email protected]

北京索莱宝科技有限公司010-50973130 17801761073 · [email protected]

화합물 노트

불러오는 중…