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기본 정보
- CAS
98672-91-4- 표준 SMILES
O=C(O)CCC/C=C\C[C@@H]1[C@H](CNNC(=O)Nc2ccccc2)[C@H]2CC[C@@H]1O2- InChIKey
RJNDVCNWVBWHLY-YVUOLYODSA-N- 분자식
- C21H29N3O4
- 평균 분자량
- 387.48 g/mol
- 단동위원소 질량
- 387.21580641
이름 및 식별자
- 우선 이름
- SQ 29548
- IUPAC
- (5Z)-7-[(1S,2R,3R,4R)-3-{[2-(Phenylcarbamoyl)hydrazinyl]methyl}-7-oxabicyclo[2.2.1]heptan-2-yl]hept-5-enoic acid
- 현지명
- SQ29,548(강력하고구체적인트롬복사NEA2수용체
- 영어명
- SQ 29,548 (POTENT AND SPECIFIC THROMBOXA NE A2 RECEPT
- 분자식
- C21H29N3O4
- 분자량
- 387.47
이름 및 동의어
SQ29,548(강력하고구체적인트롬복사NEA2수용체5-Heptenoic acid, 7-[(1S,2R,3R,4R)-3-[[2-[(phenylamino)carbonyl]hydrazinyl]methyl]-7-oxabicyclo[2.2.1]hept-2-yl]-, (5Z)-BMS-18290RJNDVCNWVBWHLY-BHQIHCQQSA-NSQ 29,548 (POTENT AND SPECIFIC THROMBOXA NE A2 RECEPT1S-[1α,2β(5Z),3β,4α]]-7-[3-[2-(Phenylcarbamoyl)hydrazinomethyl]-7-oxabicyclo[2.2.1]hept-2-yl]-5-heptenoic acid(Z)-7-[(1R,4S)-3α-[[2-[(Phenylamino)carbonyl]hydrazino]methyl]-7-oxabicyclo[2.2.1]heptan-2α-yl]-5-heptenoic acid1S-[1α,2α(Z),3α,4α]]-7-[3-[[2-[(phenylamino)carbonyl]hydrazino]methyl]-7-oxabicyclo[2.2.1]hept-2-yl]-5-heptenoicacid
데이터베이스 식별자
- CAS
98672-91-4- PubChem CID
- 5311448
- DTXSID
DTXSID50873403- ChEMBL
CHEMBL365308
물성
물리화학적 성질
- 녹는점
- 92 · 92-95 °C
- 밀도
- 1 · 1+-.0.06 g/cm3(Predicted)
- 저장 조건
- -20 °C · Store at -20°C
- 용해도
- 0.9 mg/ml · ≤0.9mg/ml in ethanol;5mg/ml in DMSO;0.14mg/ml in dimethyl formamide
- 물리적 상태
- 백색 내지 황백색의 결정성 분말.
- 산도 계수 (pKa)
- 4.76 · 4.76±0.10(Predicted)
- 색상
- White to off-white
화학 및 산업
응용 분야
개요SQ 29,548 is a highly selective TP receptor antagonist which binds to the human recombinant TP receptor with a Ki of 4.1 nM. It inhibits the aggregation of washed human platelets induced by U-46619 with an IC50 of 0.06 μM. It antagonizes U-46619 induced contraction of rat and guinea pig tracheal, arterial, and venous smooth muscles with drug/receptor dissociation constants (KB) in the range of 0.5-1.7 nM. SQ 29,548 also inhibits the contraction of rat vascular smooth muscle induced by 8-iso PGF2α.
용도SQ-29548 is a potent and selective thromboxane A2 receptor antagonist.
공급사6 곳
上海优宁维生物科技股份有限公司15921930842 15921930842 · [email protected]
Aladdin Scientific[email protected]
銳迪國際科技有限公司18024082417 · [email protected]
天津普西唐生物医药科技有限公司010-60605840 · [email protected]
上海一飞生物科技有限公司021-65675885 18964387627 · [email protected]
ChemeGen 中国18818260767 · [email protected]
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