N-메틸피페라진

1-메틸피페라진 · N-메틸피페라진 · N-METHYLPIPERAZINE · methylpiperazine · 4-Methylpiperazine · NMPRZ · 1-Methyipiperazine · N-Methylpiperazin

https://huagongshe.com/ko/chemical/53167

식별자 및 물리적 특성

CAS No.	109-01-3
분자식	C5H12N2
평균 분자량	100.16 g/mol
단동위원소 질량	100.10004839 g/mol
SMILES	CN1CCNCC1
InChIKey	PVOAHINGSUIXLS-UHFFFAOYSA-N
PubChem CID	53167
ChEMBL	CHEMBL1011
ChEBI	CHEBI:166561
EC No.	203-639-5
DTXSID	DTXSID4021898
현지명	N-메틸피페라진

화학 및 물리적 성질

XLogP	-0.4
극성 표면적	15.3
수소 결합 공여자 수	1
수소 결합 수용자 수	2
회전 가능 결합 수	0
무거운 원자 수	7
형식 전하	0
복잡도	48
증기압	3.0 [mmHg]12 hPa (20 °C)
Physical Description	Clear light yellow hygroscopic liquid[Sigma-Aldrich MSDS]
Kovats Retention Index	839847852838.5126612701274128212861262
녹는점	-6 °C
끓는 점	138 °C(lit.)
밀도	0.903 g/mL at 25 °C(lit.)
증기 밀도	3.5 (vs air)
굴절률	n20/D 1.466(lit.)
인화점	108 °F
저장 조건	2-8°C
용해도	클로로포름(용해성), 메탄올(용해성)
pKa(산도 계수)	pK1:4.94(+2)pK2:9.09(+1) (25°C,μ=0.1)
물리적 상태	액체
비중	0.903
색상	투명한
pH	11-12 (50g/l, H2O, 20℃)
폭발한계	1.2-9.9%(V)
용해도	녹는
BRN	102724
헨리 상수	1.8×103 mol/(m3Pa) at 25℃, Nguyen (2013)
InChI	1S/C5H12N2/c1-7-4-2-6-3-5-7/h6H,2-5H2,1H3
InChIKey	PVOAHINGSUIXLS-UHFFFAOYSA-N
SMILES	CN1CCNCC1
LogP(분배 계수)	-0.57 at 25℃
표면장력	30.65mN/m at 298.15K
NIST	Piperazine, 1-methyl-(109-01-3)
EPA	Piperazine, 1-methyl- (109-01-3)

화학적 성질

clear liquid

안전 및 규제

GHS 분류	This chemical does not meet GHS hazard criteria for 1.1% (4 of 377) of reports.DangerH226 (98.7%): Flammable liquid and vapor [Warning Flammable liquids]H312 (44.8%): Harmful in contact with skin [Warning Acute toxicity, dermal]H314 (98.9%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]H317 (53.8%): May cause an allergic skin reaction [Warning Sensitization, Skin]H318 (51.7%): Causes serious eye damage [Danger Serious eye damage/eye irritation]H330 (24.4%): Fatal if inhaled [Danger Acute toxicity, inhalation]H331 (12.5%): Toxic if inhaled [Danger Acute toxicity, inhalation]H332 (56.8%): Harmful if inhaled [Warning Acute toxicity, inhalation]P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P271, P272, P280, P284, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P320, P321, P333+P317, P362+P364, P363, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 377 reports by companies from 24 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.Reported as not meeting GHS hazard criteria per 4 of 377 reports by companies.There are 23 notifications provided by 373 of 377 reports by companies with hazard statement code(s).Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.
규제 정보	Chemical: Piperazine, 1-methyl-Status: Active Update: 08-07-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/13739Status: Active Update: 20-10-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/183231-Methylpiperazine: Does not have an individual approval but may be used under an appropriate group standardThe New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)
유해성 요약

GHS 분류

This chemical does not meet GHS hazard criteria for 1.1% (4 of 377) of reports.DangerH226 (98.7%): Flammable liquid and vapor [Warning Flammable liquids]H312 (44.8%): Harmful in contact with skin [Warning Acute toxicity, dermal]H314 (98.9%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]H317 (53.8%): May cause an allergic skin reaction [Warning Sensitization, Skin]H318 (51.7%): Causes serious eye damage [Danger Serious eye damage/eye irritation]H330 (24.4%): Fatal if inhaled [Danger Acute toxicity, inhalation]H331 (12.5%): Toxic if inhaled [Danger Acute toxicity, inhalation]H332 (56.8%): Harmful if inhaled [Warning Acute toxicity, inhalation]P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P271, P272, P280, P284, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P320, P321, P333+P317, P362+P364, P363, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 377 reports by companies from 24 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.Reported as not meeting GHS hazard criteria per 4 of 377 reports by companies.There are 23 notifications provided by 373 of 377 reports by companies with hazard statement code(s).Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

규제 정보

Chemical: Piperazine, 1-methyl-Status: Active Update: 08-07-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/13739Status: Active Update: 20-10-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/183231-Methylpiperazine: Does not have an individual approval but may be used under an appropriate group standardThe New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)

유해성 요약

용도

N- 메틸 피페 라진 또는 N- 메틸 피페 라진은 리팜피신, 항 정신 이상제 트리 플루오로 페라 진, 오브 록 사신 등의 항균제 생산에 사용됩니다.그것은 주로 항 미세 요법 약물 인 2- (4- 메틸 -1- 피 페라 지닐 메틸) 아크릴 페논 (MPMAP)의 제조에 사용됩니다.

용도

1-Methylpiperazine is used in the preparation of 2-(4-Methyl-1-piperazinylmethyl)acrylophenone(MPMAP)