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기본 정보
- CAS
101574-65-6- 표준 SMILES
CC(C)c1ccc(/C=N/NC(=O)c2ccc(O)cc2)cc1- InChIKey
IKPPIUNQWSRCOZ-WOJGMQOQSA-N- 분자식
- C17H18N2O2
- 평균 분자량
- 282.343 g/mol
- 단동위원소 질량
- 282.13682782
이름 및 식별자
- 우선 이름
- GSK 4716
- IUPAC
- 4-Hydroxy-N'-{(E)-[4-(propan-2-yl)phenyl]methylidene}benzohydrazide
- 영어명
- 4-Hydroxy-2-[(1E)-[4-(1-methylethyl)phenyl]methylene]hydrazide
- 분자식
- C17H18N2O2
- 분자량
- 282.34
이름 및 동의어
CS-1084GSK-4716, 10 mM in DMSOGSK 4716, ERRbetagamma agonist4-hydroxy-N'-(4-isopropylbenzylidene)benzohydrazide(E)-4-hydroxy-N'-(4-isopropylbenzylidene)benzohydrazide4-hydroxy-N'-(4-isopropylphenyl‐ methylidene)-benzohydrazide4-Hydroxy-2-[(1E)-[4-(1-methylethyl)phenyl]methylene]hydrazide2-[[4-(1-Methylethyl)phenyl]methylene]hydrazide 4-hydroxybenzoic acid4-Hydroxybenzoic acid 2-[[4-(1-methylethyl)phenyl]methylene]hydrazideBenzoic acid, 4-hydroxy-, 2-[[4-(1-methylethyl)phenyl]methylene]hydrazide
데이터베이스 식별자
- CAS
101574-65-6- PubChem CID
- 5331325
- DTXSID
DTXSID40416242- ChEMBL
CHEMBL193836- ChEBI
CHEBI:80000- Nikkaji
- J2.404.851I
물성
물리화학적 성질
- 밀도
- 1.12 · 1.12
- 저장 조건
- 2 · Inert atmosphere,2-8°C
- 용해도
- 10 mg/mL · DMSO: >10mg/mL
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- 8.48 · 8.48±0.15(Predicted)
- 색상
- 흰색에서 황백색까지
- InChI
- 1S/C17H18N2O2/c1-12(2)14-5-3-13(4-6-14)11-18-19-17(21)15-7-9-16(20)10-8-15/h3-12,20H,1-2H3,(H,19,21)/b18-11+
- InChIKey
- IKPPIUNQWSRCOZ-WOJGMQOQSA-N
- SMILES
- CC(C)c1ccc(cc1)\C=N\NC(=O)c2ccc(O)cc2
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
안전 데이터
- wgk
- 3
- ridadr
- UN 3077 9 / PGIII
- risk_code
- 43-50/53
- hazard_code
- Xi,N
- safety_code
- 36/37-60-61
- 위험 등급
- 9
- Hazard Classifications
- Aquatic Acute 1Aquatic Chronic 1Skin Sens. 1
- 스토리지 클래스
- 11 - Combustible Solids
화학 및 산업
응용 분야
개요The estrogen-related receptors (ERRs) are orphan nuclear receptors with homology to the estrogen receptor family and are expressed in tissues with high metabolic demand. Binding of peroxisome proliferator-activated receptor γ-coactivator 1α (PGC-1α) to this class of receptors is known to potentiate ERR activity. GSK4716 is an ERRβ/γ agonist (IC50 = 2 μM) that can activate the receptor with similar potency as the protein ligand, PGC-1α. It is more than 50-fold selective for binding to ERRβ/γ compared with the estrogen receptors. This compound has been used to demonstrate the contribution of ERR receptor activity to the regulation of mitochondrial activity in skeletal muscle during exercise.
용도The estrogen-related receptors (ERRs) are orphan nuclear receptors with homology to the estrogen receptor family and are expressed in tissues with high metabolic demand. Binding of peroxisome proliferator-activated receptor γ-coactivator 1α (PGC-1α) to this class of receptors is known to potentiate ERR activity. GSK4716 is an ERRβ/γ agonist (IC50 = 2 μM) that can activate the receptor with similar potency as the protein ligand, PGC-1α. It is more than 50-fold selective for binding to ERRβ/γ compared with the estrogen receptors. This compound has been used to demonstrate the contribution of ERR receptor activity to the regulation of mitochondrial activity in skeletal muscle during exercise.[Cayman Chemical]
공급사64 곳
武汉英诺医药科技有限公司+86-027-59232304 15387063101 · [email protected]
成都超九八生物科技有限公司13348960310 13348960310 · [email protected]
湖北科乐精细化工有限公司027-59101668 19945030958 · [email protected]
武汉易泰科技有限公司上海分公司18930552037 · [email protected]
欧利希（湖北）医药科技有限公司17316404525 17316404525 · [email protected]
InvivoChem中国
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