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HCID 533728생성일: 2026년 10월 27일

나트륨 디에틸디티오카르밤산 염

나트륨다이에틸다이싸이오카밤산염 · 나트륨디에틸디티오카르밤산염 · 나트륨디에틸디티오카르바메이트 · DDTC · DTC · dithiocarbamate · dedc · NADEDC

https://huagongshe.com/ko/chemical/533728

나트륨 디에틸디티오카르밤산 염 분자 구조식

식별자 및 물리적 특성

CAS No.148-18-5
분자식(C2H5)2NCS2Na
평균 분자량171.3 g/mol
단동위원소 질량171.0152356 g/mol
SMILESCCN(CC)C(=S)[S-].[Na+]
InChIKeyIOEJYZSZYUROLN-UHFFFAOYSA-M
PubChem CID533728
ChEMBLCHEMBL107217
ChEBICHEBI:82587
EC No.205-710-6
DTXSIDDTXSID3022956
현지명나트륨 디에틸디티오카르밤산 염

화학 및 물리적 성질

극성 표면적36.3
수소 결합 공여자 수0
수소 결합 수용자 수2
회전 가능 결합 수2
무거운 원자 수9
형식 전하0
복잡도83
PolymersPlastics & Rubber -> Dithiocarbamates (Rubber)
농약Pesticide -> EPA IRIS
LogP(분배 계수)log Kow <1.10
밀도1.1 at 68 °F (NTP, 1992) - Denser than waterwill sink1.1 g/cu cm at 20 °C/20 °CRelative density (water = 1): 1.11.1 @ 20°C1.1000
Color/FormCrystals from ethanolYellow to green liquid at 20 °C and 1013 hPa (solution in water)
용해도greater than or equal to 100 mg/mL at 57 °F (NTP, 1992)Soluble in waterSoluble in alcoholSolubility in water: solubleabout 35 % in water, less soluble in organic solvents. However, the free acid, diethyldithiocarbamic acid, is readily soluble in organic solvents and less soluble in water. Thus, on acidification of an aqueous solution of a diethyldithiocarbamate, the free acid can be extracted with chloroform or carbon tetrachloride. The distribution ratio is 2,360 for chloroform and 343 for carbon tetrachloride.
DecompositionWhen heated to decomposition it emits very toxic fumes of /nitrogen, sulfur, and sodium oxides/.
녹는점203 °F (NTP, 1992)95 °C90-102 °C95°C
증기 밀도5.9 (NTP, 1992) - Heavier than airwill sink (Relative to Air)5.9 (Air = 1)Relative vapor density (air = 1): 5.9
Physical DescriptionSodium diethyldithiocarbamate appears as odorless white or slightly brown or slightly pink crystals. (NTP, 1992)[ICSC]WHITE CRYSTALS.
Stability/Shelf LifeStable under recommended storage conditions. /Sodium diethyldithiocarbamate trihydrate/Aqueous solutions decompose slowly.
Other Experimental PropertiesAQUEOUS SOLN IS ALKALINE TO LITMUS & PHENOLPHTHALEINSolubility in water = 2.9X10+4mg/Llog Kow = 1.67VP: 0.121 mm HgHenry's Law constant = 6.84X10-4 atm-cu m/molHydroxyl radical reaction rate constant = 2.0X10-10 cu cm/molecule-sec (all estimated at 25 °C) /Ditiocarb/Thin, irregular plate-like crystals from acetone, mp 94-102 °C. Also reported as 90-92 °C. Freely soluble in watersoluble in ethanol, methanol, acetone. Insoluble in ether, benzene. The aqueous solution is alkaline to litmus and phenolphthalein and slowly decomposes. (pH of 10% aqueous solution is 11.6 at room temperature). The addition of an acid to the aqueous solution produces a white turbidity due to the liberation of carbon disulfide. UV max (ethanol): 257, 290 nm (epsilon 1200, 1300) /Sodium diethyldithiocarbamate trihydrate/Greenish-yellow liquid with a characteristic smell comprising a 23% solution in water
증기압0Pa at 20℃
저장 조건Keep in dark place,Inert atmosphere,Room temperature
pKa(산도 계수)3.3
물리적 상태액체
색상투명, 무색
비중1.08
냄새흰색, 약간.갈색 또는 약간 분홍색의 무취 결정.
용해도14 ºC에서 >=10g/100 mL
LogP(분배 계수)-1.1 at 20℃
EPASodium diethyldithiocarbamate (148-18-5)

화학적 성질

Sodium diethyldithiocarbamate is a white or colorless crystalline powder, easily soluble in water and alkaline, soluble in alcohol, rapidly decomposed in acidic aqueous solution to separate out carbon disulfide and make the solution cloudy. In ammonia medium, it generates precipitate or brown colloidal solution with copper ion. Copper reagent is applied in the color development reaction of copper, used as precipitant and solvent extractant of soft metal ions, also used as photometric reagent for the determination of bismuth, copper, nickel and other metals.

안전 및 규제

GHS 분류WarningH302 (71.2%): Harmful if swallowed [Warning Acute toxicity, oral]P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 66 reports by companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.H302: Harmful if swallowed [Warning Acute toxicity, oral]
규제 정보Chemical: Carbamodithioic acid, diethyl-, sodium saltStatus: Active Update: 30-08-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/11278Sodium diethyldithiocarbamate: Does not have an individual approval but may be used under an appropriate group standard
운송 라벨(DOT)Class 9
화재 위험Flash point data for this chemical are not availablehowever, it is probably combustible. (NTP, 1992)Combustible. Gives off irritating or toxic fumes (or gases) in a fire.
건강 유해성SYMPTOMS: Symptoms of exposure to this chemical include irritation of the eyes. Continued exposure may cause mild skin irritation. The dusts of this compound are caustic to the mucous membranes. This compound is also caustic to the digestive tract.
유해성 요약Symptoms of exposure to this chemical include irritation of the eyes. Continued exposure may cause mild skin irritation. The dusts of this compound are caustic to the mucous membranes. This compound is also caustic to the digestive tract. [CAMEO] Danger of sensitization of the skin[MAK] See Carba mix.
반응성 그룹Thiocarbamate Esters and Salts/Dithiocarbamate Esters and Salts
UN 분류UN Hazard Class: 9UN Pack Group: III
Special ReportsDHEW/NCIBioassay of Sodium Diethyldithiocarbamate for Possible Carcinogenicity (1979) Technical Rpt Series No. 172 DHEW Pub No. (NIH) 79-1728
Reactivity ProfileSODIUM DIETHYLDITHIOCARBAMATE is not compatible with strong oxidizing agents. Aqueous solutions slowly decompose to form carbon disulfide and an amine. Such decompositions are accelerated by acids. Addition of acid to the aqueous solution produces a white turbidity (NTP, 1992).

용도

용도

Sodium diethyldithiocarbamate is an organic molecular entity. It is an inhibitor of superoxide dismutase, having both antioxidant and oxidant effects.

일반 설명

Odorless white or slightly brown or slightly pink crystals.

제조 및 합성 방법

제조 방법

This salt is obtained by treating carbon disulfide with diethylamine in the presence of sodium hydroxide:CS2+ HN(C2H5)2+ NaOH → NaS2CN(C2H5)2+ H2O

Chemical DangersDecomposes on heating. This produces toxic fumes including sulfur oxides, nitrogen oxides and sodium oxide. The substance is a weak base.
Air and Water ReactionsWater soluble. Thio and dithiocarbamates slowly decompose in aqueous solution to form carbon disulfide and methylamine or other amines. Such decompositions are accelerated by acids.
Toxic Combustion ProductsSpecial hazards arising from the substance or mixture: Carbon oxides, Nitrogen oxides (NOx), Sulfur oxides, Sodium oxides. /Sodium diethyldithiocarbamate trihydrate/
소화Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. A water spray may also be used. (NTP, 1992)Use water, foam, carbon dioxide, powder.
응급 조치Fresh air, rest.Remove contaminated clothes. Rinse skin with plenty of water or shower.First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.Rinse mouth. Give one or two glasses of water to drink.
응급 처치EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.
안전 보관Dry. Well closed. Keep in a well-ventilated room. Store in an area without drain or sewer access.
노출 관리 및 개인 보호2.0 [mg/m3], inhalable fraction[German Research Foundation (DFG)]
소화 절차Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. /Sodium diethyldithiocarbamate trihydrate/Advice for firefighters: Wear self-contained breathing apparatus for firefighting if necessary. /Sodium diethyldithiocarbamate trihydrate/
보관 조건Keep container tightly closed in a dry and well-ventilated place. Hygroscopic. Store under inert gas. /Sodium diethyldithiocarbamate trihydrate/
정리 방법ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dustEnvironmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoidedMethods and materials for containment and cleaning up: Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal. /Sodium diethyldithiocarbamate trihydrate/
비화재 누출 대응SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
처리 방법SRP: Expired or waste pharmaceuticals shall carefully take into consideration applicable DEA, EPA, and FDA regulations. It is not appropriate to dispose by flushing the pharmaceutical down the toilet or discarding to trash. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.Product: Offer surplus and non-recyclable solutions to a licensed disposal companyContaminated packaging: Dispose of as unused product. /Sodium diethyldithiocarbamate trihydrate/
누출 처리Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
Preventive MeasuresPrecautions for safe handling: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Further processing of solid materials may result in the formation of combustible dusts. The potential for combustible dust formation should be taken into consideration before additional processing occurs. Provide appropriate exhaust ventilation at places where dust is formed. /Sodium diethyldithiocarbamate trihydrate/Appropriate engineering controls: Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. /Sodium diethyldithiocarbamate trihydrate/Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. /Sodium diethyldithiocarbamate trihydrate/SRP: Local exhaust ventilation should be applied wherever there is an incidence of point source emissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimize personnel exposure to airborne contaminants. Ensure that the local ventilation moves the contaminant away from the worker.
상호 작용Rats exposed to enflurane (100 ppm) or methoxyflurane (300 ppm) in a closed all glass system eliminated these anesthetics from atmosphere with half life of 6.84 hr for enflurane and 0.64 for methoxyflurane. Pretreatment with dithiocarb (100 mg/kg ip) prolonged elimination half life of both compounds.Rat liver microsomes catalyze covalent binding of (14)C-carbon tetrachloride metabolites to the microsomal proteinthis binding was inhibited by dithiocarb at an I50 (50% inhibition) of 2.3x10-5 moles. Dithiocarb effectively inhibited metabolic elimination of carbon tetrachloride at a dose of 100 mg/kg.Dithiocarb increased T-cell associated responses in mice treated with azathioprine or hydrocortisone acetate. Such a beneficiary effect contrasted with its inefficiency to restore functions abrogated by cyclophosphamide. The results raise the possibility of developing a rational chemoimmunotherapy using dithiocarb with a compatible cytoreductive drug.Sc injection of 0.5 mmoles dithiocarb, 30 min before an ip injection of 280 mg aniline- hydrocloric acid/kg, affected aniline toxicity to rats by increasing mortality from 41.6 to 75%, decreasing methemoglobin formation by 67.72%, and inhibiting hepatic aniline hydroxylase by 47.6%.For more Interactions (Complete) data for SODIUM DIETHYLDITHIOCARBAMATE (15 total), please visit the HSDB record page.
생태독성 수치LC50Species: Poecilia reticulata (Guppy)Conditions: renewalConcentration: 6.9 mg/L for 96 hr (95% confidence interval: 5.5-8.5 mg/L)Species: Daphnia magna (Water flea)Concentration: 910 ug/L for 48 hr (95% confidence interval: 710-1060 ug/L)EC50Species: Chlorella pyrenoidosa (Green Algae) 10+8 cells/100 mLConditions: freshwater, static, 20 °CConcentration: 1400 ug/L for 96 hrEffect: growth, general /99% purity/Species: Cyprinodon variegatus (Sheepshead minnow)Conditions: flow throughConcentration: 107 mg/L for 24 hrFor more Ecotoxicity Values (Complete) data for SODIUM DIETHYLDITHIOCARBAMATE (18 total), please visit the HSDB record page.
유해 작용Skin Sensitizer - An agent that can induce an allergic reaction in the skin.
노출 경로The substance can be absorbed into the body by ingestion.
독성 요약IDENTIFICATION AND USE: Sodium diethyldithiocarbamate (DETC) is a solid. It is used as corrosive inhibitor, rubber accelerator, intermediate, polymerization shortstop, and chemical intermediate in production of bis(thiocarbamoyl)sulfides (rubber-processing accelerators and fungicides). It is also used for colorimetric determination of small quantities of copper and for its separation from other metals, as well as spin trap (as FeDETC complex) for nitric oxide detection. DETC has also been used as a medication and antidote in nickel carbonyl exposures. HUMAN EXPOSURE AND TOXICITY: Allergic contact dermatitis from a wet suit was related to zinc diethyldithiocarbamate. ANIMAL STUDIES: Zinc diethyldithiocarbamate and DETC were positive in the murine local lymph node assay (LLNA). Administered systemically, DETC is reported to have caused detachment of the retina in dogs, but no damage to the retina in monkeys. In albino rats and beagle dogs, it caused no impairment of vision or structural alteration in the eye after daily administration for ninety days. In a 6-wk experiment in mice, daily sc injection of 50 mg/kg bw had marked anti-thyroid activity. DETC administered to rabbits at 100, 200, and 400 mg/kg daily for 4 weeks increased triglyceride and phospholipid levels. No changes were found in serum cholesterol concentration. DETC reduces blood copper concentrations. Pregnant rabbits injected intravenously with 0.5 g sodium diethyldithiocarbamate/day on 5 days per week throughout pregnancy failed to deliver litters. DETC elevated copper levels in the brain and peripheral nerve, leading to oxidative stress and lipid peroxidation from redox cycling of copper. Lipid peroxidation appears to either be a contributing event in the development of demyelination, possibly through an increase of redox active copper, or a consequence of the myelin injury. Continued DETC exposure induced an extensive degeneration of axons and myelin sheath (Wallerian degeneration in axons). DETC was not carcinogenic to rats or mice in NTP bioassay. Sodium diethyldithiocarbamate was negative when tested using Salmonella typhimurium strains (TA1535, TA1537, TA97, TA98 and TA100) in the presence and absence of metabolic activation. However, a small but significant increase in the number of chromosome breakages and aberrations was found in Vicia faba. DETC given orally to young and adult domestic fowl produced retarded testicular development, and produced degeneration in the seminiferous epithelium of mature birds. Nerve fiber degeneration was produced in the medulla and spinal cord of chicks. ECOTOXICITY STUDIES: DETC>3 mg/L applied to developing frog embryos was lethal in 24 hr. Between 1-3 mg/L caused severely malformed embryos. Retardation of growth, curvature of body axis, general edemic condition, pigmentation disorders, and abnormal notochords were noted.
생태독성 발췌/AQUATIC SPECIES/ The effects of intraperitoneal injection of diethyldithiocarbamate (DDC) on free radical processes were examined in brain, liver and kidney of goldfish (Carassius auratus). Levels of oxidatively modified lipids and proteins as well as the activities of antioxidant and associated enzymes were measured. Intraperitoneal injection of DDC at a concentration of 0.01 mg/g wet mass decreased SOD activities by about 30-50% after 48 and 168 hr compared to corresponding sham-injected values. This treatment resulted in transient oxidative stress. Lipid peroxide content increased after DDC injection at all time points in the kidney, after 48 hr in the liver and was elevated in most experimental groups in the brain. Thiobarbituric-acid reactive substances (end products of lipid peroxidation) rose within the first 48 hr after injection, but returned to initial levels after 168 hr. Two other indices of oxidative stress were also transiently modified: protein carbonyl levels in the brain and kidney increased 24 hr post-injection, and the low-molecular mass thiol content was reduced over the same period in all tissues examined. Activities of catalase, glutathione peroxidase, glutathione-S-transferase, glutathione reductase, and glucose-6-phosphate dehydrogenase showed differential responses to DDC treatment that rebounded by 168 hr post-injection. Glutathione peroxidase activities were reduced by 60, 45 and 65% in the brain, liver and kidney, respectively, after 24 hr but rebounded thereafter. After 48 hr post-injection with DDC significant decreases were also seen in liver and kidney catalase, GST activities in all three tissues, and kidney GR and G6PDH activities. In some cases, catalase, GST, GR and G6PDH activities transiently increased after 24 hr. It was concluded that DDC injection depleted SOD and simultaneously stimulated lipid peroxidation, but did not require compensatory enhancement of other enzymatic defenses. Different actions of the superoxide anion in cellular metabolism and possible consequences of the impairment of superoxide dismutase are discussed./AQUATIC SPECIES/ Sodium diethyldithiocarbamate concentration >3 mg/L applied to developing frog embryos were lethal in 24 hr. Between 1-3 mg/L caused severely malformed embryos. Retardation of growth, curvature of body axis, general edemic condition, pigmentation disorders, and abnormal notochords were noted.
Signs and SymptomsCough. Sore throat.Redness.Abdominal pain. Drowsiness. Nausea.
Ongoing Test StatusEPA has released the Interactive Chemical Safety for Sustainability (iCSS) Dashboard. The iCSS Dashboard provides an interactive tool to explore rapid, automated (or in vitro high-throughput) chemical screening data generated by the Toxicity Forecaster (ToxCast) project and the federal Toxicity Testing in the 21st century (Tox21) collaboration. /The title compound was tested by ToxCast and/or Tox21 assays/[USEPAICSS Dashboard ApplicationAvailable from, as of December 17, 2015: http://actor.epa.gov/dashboard/]The following link will take the user to the National Toxicology Program (NTP) Test Agent Search Results page, which tabulates all of the "Standard Toxicology & Carcinogenesis Studies", "Developmental Studies", and "Genetic Toxicity Studies" performed with this chemical. Clicking on the "Testing Status" link will take the user to the status (i.e., in review, in progress, in preparation, on test, completed, etc.) and results of all the studies that the NTP has done on this chemical.[Available from: http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?fuseaction=ntpsearch.searchresults&searchterm=148-18-5]
ICSC Environmental DataThe substance is very toxic to aquatic organisms. It is strongly advised not to let the chemical enter into the environment.
EPA IRIS InformationSodium diethyldithiocarbamate3 x 10 ^-2 mg/kg-day
Natural Pollution SourcesSodium diethyldithiocarbamate is not known to occur as a natural product.
Human Toxicity Excerpts/CASE REPORTS/ Rubber materials are common causes of contact dermatitis. Neoprene is a special synthetic rubber used in many products (eg, wet suits, elastic supports, gloves, shoes, and orthopedic devices). A 31-year-old man was admitted to our dermatoallergologic clinic with the development of a generalized itching erythematovesicular eruption. He reported that clinical manifestations occurred after he wore a neoprene wet suit that he was used to wearing for water sports. Although allergic contact dermatitis from a wet suit is not uncommon, it is usually due to thiourea derivatives whereas our patient presented with contact allergy to p-tert-butylphenol formaldehyde resin and zinc diethyldithiocarbamate. /Zinc diethyldithiocarbamate//ALTERNATIVE and IN VITRO TESTS/ Tumor necrosis factor-alpha (TNF-alpha) and etoposide both trigger a large and rapid production of reactive oxygen species (ROS) in HeLa cells. This occurs before translocations of the proapoptotic Bax and cytochrome c proteins, the loss of mitochondrial membrane potential (DeltaPsim), and apoptosis. We have used diethyldithiocarbamate (DDC), a well-known inhibitor of Cu, Zn superoxide dismutase to study the role of ROS in this system. We report that DDC strongly inhibits caspase activation, loss of DeltaPsim, and cell death induced by TNF-alpha or etoposide. Surprisingly, DDC does not inhibit Bax and cytochrome c translocations. On the contrary, we have observed that DDC can trigger the translocations of these proteins by itself, without altering DeltaPsim. Here, we report that DDC has at least two antagonistic apoptosis regulation functions. First, DDC triggers ROS-dependent Bax and cytochrome c translocations, which are potentially proapoptotic, and second, DDC inhibits caspase activation and activity, loss of DeltaPsim, and cell death, in a ROS-independent manner. Our results suggest an interesting model in which ROS-dependent Bax and cytochrome c translocations can be studied without interference from later apoptotic events./ALTERNATIVE and IN VITRO TESTS/ Antimycin A (AMA) inhibits mitochondrial electron transport between cytochrome b and c. We recently demonstrated that AMA inhibits the growth of lung cancer Calu-6 cells and the changes of reactive oxygen species (ROS) and glutathione (GSH) levels affect apoptosis in Calu-6 cells. Here, we examined the effects of N-acetyl-cysteine (NAC, a well known antioxidant), L-buthionine sulfoximine (BSO, an inhibitor of GSH synthesis), diethyl-dithiocarbamate (DDC, an inhibitor of Cu, Zn-SOD) or 3-amino-1,2,4-triazole (AT, an inhibitor of catalase) on AMA-treated Calu-6 cells in relation to cell death, ROS and GSH levels. Treatment with AMA induced cell growth inhibition, apoptosis and the loss of mitochondrial membrane potential (MMP) (DeltaPsim) in Calu-6 cells. While the intracellular ROS level was decreased in 50 microM AMA-treated Calu-6 cells, O2.- levels among ROS were significantly increased. AMA also induced GSH depletion in Calu-6 cells. Treatment with NAC showed decreasing effect on O2.- levels in AMA-treated cells preventing apoptosis, MMP (DeltaPsim) loss and GSH depletion in these cells. BSO significantly increased GSH depletion and apoptosis in AMA-treated cells. While both DDC and AT increased ROS levels in AMA-treated Calu-6 cells, only DDC intensified GSH depletion and apoptosis. BSO and AT increased the ROS level in Calu-6 control cells, but these agents did not induce apoptosis and GSH depletion. In conclusion, our results suggest that GSH depletion rather than ROS level in AMA-treated Calu-6 cells is more tightly related to apoptosis./ALTERNATIVE and IN VITRO TESTS/ Propyl gallate (PG) as a synthetic antioxidant is widely used in processed food and medicinal preparations. It also exerts a variety of effects on tissue and cell functions. In the present study, we investigated the effects of L-buthionine sulfoximine (BSO, an inhibitor of GSH synthesis), diethyldithiocarbamate (DDC, an inhibitor of Cu/Zn-SOD) or 3-amino-1,2,4-triazole (AT, an inhibitor of catalase) on PG-treated HeLa cells in relation to cell growth, reactive oxygen species (ROS) and glutathione (GSH). Treatment with PG induced growth inhibition, the loss of mitochondrial membrane potential [MMP (DeltaPsim)] and apoptosis in HeLa cells. ROS levels including O2.- were increased or decreased in PG-treated HeLa cells depending on the incubation times. PG caused depletion in GSH content in HeLa cells. While BSO enhanced the growth inhibition of PG-treated HeLa cells at 4 hr, DDC and AT did not. All the agents down-regulated MMP (DeltaPsim) levels in PG-treated cells. Although BSO, DDC or AT slightly increased ROS or O2.- levels in PG-treated cells at 1 hr, these enhancements of ROS did not intensify apoptosis in these cells. In addition, BSO, DDC or AT slightly reduced GSH level in PG-treated HeLa cells at 1 hr, but this reduction did not affect cell death of HeLa. Furthermore, PG induced a G1 phase arrest of the cell cycle. BSO, DDC or AT significantly inhibited the G1 phase arrest in PG-treated cells. Conclusively, the changes of ROS and GSH levels by BSO, DDC or AT in PG-treated HeLa cells did not strongly affect the cell growth and death.For more Human Toxicity Excerpts (Complete) data for SODIUM DIETHYLDITHIOCARBAMATE (7 total), please visit the HSDB record page.
TSCA 등재 상태TSCA listed
운송 번호(UN)3077
포장분류III
위험 등급9
기존화학 물질KE-10449
유해 물질 데이터148-18-5(Hazardous Substances Data)