Methanesulfonic acid--2-amino-5-{[4-(methanesulfonyl)phenyl]methylidene}-1-methyl-1,5-dihydro-4H-imidazol-4-one (1/1)

개요ZLJ-6 is a dual inhibitor of COX and 5-lipoxygenase (5-LO) (IC50 = 0.73, 0.31, and 0.99 μM for COX-1, COX-2, and 5-LO, respectively, in whole blood). It reduces carrageenin-induced paw edema (inflammation) in rats and acetic acid-induced abdominal constriction (pain) in mice without causing gastrointestinal ulcers, a common side effect of non-selective COX inhibitors.