17-페닐트리노프로스타글란딘F2α시클로프로필메틸아미드
N-(Cyclopropylmethyl)-7-[3,5-dihydroxy-2-(3-hydroxy-5-phenylpent-1-EN-1-YL)cyclopentyl]hept-5-enamide
기본 정보
- CAS
1138395-10-4- 표준 SMILES
O=C(CCCC=CCC1C(O)CC(O)C1C=CC(O)CCc1ccccc1)NCC1CC1- InChIKey
IBUQJJFOXZIFFM-UHFFFAOYSA-N- 분자식
- C27H39NO4
- 평균 분자량
- 441.6 g/mol
- 단동위원소 질량
- 441.28790873
이름 및 식별자
- 우선 이름
- N-(Cyclopropylmethyl)-7-[3,5-dihydroxy-2-(3-hydroxy-5-phenylpent-1-EN-1-YL)cyclopentyl]hept-5-enamide
- IUPAC
- N-(cyclopropylmethyl)-7-[3,5-dihydroxy-2-(3-hydroxy-5-phenylpent-1-enyl)cyclopentyl]hept-5-enamide
- 현지명
- 17-페닐트리노프로스타글란딘F2α시클로프로필메틸아미드
- 영어명
- 17-phenyl trinor Prostaglandin F2α cyclopropyl methyl amide
- 분자식
- C27H39NO4
- 분자량
- 441.6
이름 및 동의어
C27H39NO4DTXSID30693944NVB39510PD049418N-(cyclopropylmethyl)-7-[3,5-dihydroxy-2-(3-hydroxy-5-phenyl-pent-1-enyl)cyclopentyl]hept-5-enamideN-(CYCLOPROPYLMETHYL)-7-[3,5-DIHYDROXY-2-(3-HYDROXY-5-PHENYLPENT-1-EN-1-YL)CYCLOPENTYL]HEPT-5-ENAMIDE17-페닐트리노프로스타글란딘F2α시클로프로필메틸아미드Sparsentan Impurity 16cyclopropylmethylbimatoprostN-Cyclopropyl Methyl Bimatoprost17-phenyl trinor Prostaglandin F2α cyclopropyl methyl amide17-phenyl trinor Prostaglandin F2.alpha. cyclopropyl methyl amide
이름 더 보기
17-phenyl trinor Prostaglandin F2α cyclopropyl methyl amide ExclusiveN-(cyclopropylmethyl)-7-[3,5-dihydroxy-2-(3-hydroxy-5-phenylpent-1-enyl)cyclopentyl]hept-5-enamide5-Heptenamide, N-(cyclopropylmethyl)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-5-phenyl-1-penten-1-yl]cyclopentyl]-, (5Z)-
데이터베이스 식별자
- CAS
1138395-10-4- PubChem CID
- 53393950
- DTXSID
DTXSID30693944
물성
구조 계산 물성
- XLogP
- 3.2
- 극성 표면적
- 89.8 Ų
- 수소 결합 공여자 수
- 4
- 수소 결합 수용자 수
- 4
- 회전 가능 결합 수
- 13
- 무거운 원자 수
- 32
- 형식 전하
- 0
- 복잡도
- 609
물리화학적 성질
- 저장 조건
- -20 °C · Store at -20°C
- 용해도
- 3 mg/ml; · Acetonitrile: 3 mg/ml; DMF: 25 mg/ml; DMSO: 25 mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.2): .25 mg/ml
- 물리적 상태
- 결정성 고체
- 화장품 원료 기능
- 항산화제
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
안전 데이터
- 신호 어
- Danger
- 유해·위험 문구
- 암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드 H302
화학 및 산업
응용 분야
개요Prostaglandin F2α (PGF2α) activates the FP receptor, promoting smooth muscle contraction and luteolysis. 17-phenyl trinor PGF2α binds the FP receptor on ovine luteal cells with a relative potency of 756% compared to that of PGF2α. It is produced in vivo by the hydrolysis of 17-phenyl trinor PGF2α ethyl amide. 17-phenyl trinor PGF2α ethyl amide is used to reduce intraocular pressure related to glaucoma. 17-phenyl trinor PGF2α cyclopropyl methyl amide is a lipophilic analog of 17-phenyl trinor PGF2α. Amides of PGs may serve as prodrugs, as they are hydrolyzed in certain tissues to generate the bioactive free acid.
용도N-Cyclopropyl Methyl Bimatoprostis a useful reagent for developing methods for treating epithelial-related conditions including hair loss. N-Cyclopropyl Methyl Bimatoprostis also an analog ofBimatoprost (B386800), an synthetic prostamide and structurally related to prostaglandin F2α.
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