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설토프라이드

Sultopride

HCID 5357
노트반응
기본 정보개요이름 및 식별자물성안전 및 규제화학 및 산업관련 반응화합물 노트
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기본 정보

CAS
53583-79-2
표준 SMILES
CCN1CCCC1CNC(=O)c1cc(S(=O)(=O)CC)ccc1OC
InChIKey
UNRHXEPDKXPRTM-UHFFFAOYSA-N
분자식
C17H26N2O4S
평균 분자량
354.5 g/mol
단동위원소 질량
354.16132849

개요

Sultopride is a member of salicylamides.

이름 및 식별자

우선 이름
Sultopride
IUPAC
N-[(1-ethylpyrrolidin-2-yl)methyl]-5-ethylsulfonyl-2-methoxybenzamide
현지명
설토프라이드
영어명
Sultopride
분자식
C17H26N2O4S
분자량
354.468

이름 및 동의어

Sultopride53583-79-2SultopridumSultopridaAA0G3TW31WN-((1-Ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-o-anisamideBenzamide, N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-2-methoxy-DTXSID9023627N-[(1-ethylpyrrolidin-2-yl)methyl]-5-ethylsulfonyl-2-methoxy-benzamideN-((1-ethylpyrrolidin-2-yl)methyl)-5-ethylsulfonyl-2-methoxy-benzamide(+-)-SultoprideRefChem:890031
이름 더 보기
설토프라이드N-[(1-Ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-methoxybenzamideBenzamide, N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-methoxy-N-[(1-Ethylpyrrolidin-2-yl)methyl]-5-(ethylsulfonyl)-2-(methyloxy)benzamide4-amino-N-[(1-ethylpyrrolidin-2-yl)methyl]-5-ethylsulfonyl-2-methoxybenzamidBenzamide, N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-methoxy- (9CI)
DTXCID903627N05AL02N-(Ethyl-1-pyrrolidinyl-2-methyl)methoxy-2-ethylsulfonyl-5-benzamide258-641-9BarnetilTopralSultopridum [INN-Latin]LIN 1418

물성

구조 계산 물성

XLogP
1.6
극성 표면적
84.1 Ų
수소 결합 공여자 수
1
수소 결합 수용자 수
5
회전 가능 결합 수
7
무거운 원자 수
24
형식 전하
0
복잡도
517

실험 및 물리화학적 성질

LogP2.05
Human DrugsBreast Feeding; Lactation; Milk, Human; Antipsychotic Agents; Dopamine Antagonists

물리화학적 성질

녹는점
181 · 181-182 °C
끓는 점
530 · 530.0±50.0 °C(Predicted)
밀도
1.1814 · 1.1814 (rough estimate)
굴절률
1.693 · 1.6930 (estimate)
저장 조건
-20 °C · Store at -20°C
용해도
DMSO에 용해됨
산도 계수 (pKa)
13.99 · 13.99±0.46(Predicted)

안전 및 규제

안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.

GHS 분류

GHS Classification · 4건

Danger

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

P203, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P354+P338, P317, P318, P319, P321, P330, P332+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

유해성 정보

Hazard Classes and CategoriesAcute Tox. 4 (100%)

독성 정보

Effects During Pregnancy and Lactation◉ Summary of Use during Lactation

안전 데이터

신호 어
Warning
유해·위험 문구
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드 H302

화학 및 산업

약리 정보

ATC Code · 2건

N - Nervous system

QN - Nervous system

MeSH Pharmacological Classification · 3건

Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus.

Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME.

A structurally and mechanistically diverse group of drugs that are not tricyclics or monoamine oxidase inhibitors. The most clinically important appear to act selectively on serotonergic systems, especially by inhibiting serotonin reuptake.

상·하류 제품 정보

상류 원료

삼염화 인2-메톡시-5-(에틸술포닐)벤조산

공급사21 곳

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湖北金梭生物科技有限公司

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데이터베이스 식별자

CAS
53583-79-2
PubChem CID
5357
DTXSID
DTXSID9023627
ChEMBL
CHEMBL277945
ChEBI
CHEBI:9356
UNII
AA0G3TW31W
EC Number
258-641-9
Nikkaji
J10.063C
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