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기본 정보
- CAS
111149-87-2- 표준 SMILES
CC1=C(CC/C(C)=C/CC/C(C)=C/CCC2=CC(=O)OC2O)C(C)(C)CCC1- InChIKey
JPWPYTMXSXYUPG-QZPYEDBESA-N- 분자식
- C25H38O3
- 평균 분자량
- 386.576 g/mol
- 단동위원소 질량
- 386.28209508
이름 및 식별자
- 우선 이름
- Luffariellolide
- 현지명
- 루파리엘리리드
- 영어명
- LUFFARIELLOLIDE
- 분자식
- C25H38O3
- 분자량
- 386.57
이름 및 동의어
루파리엘리리드LUFFARIELLOLIDELuffariellolide, phospholipase A2 (PLA2) inhibitor. Agonist at RARalpha3-[(3E,7E)-4,8-dimethyl-10-(2,6,6-trimethylcyclohexen-1-yl)deca-3,7-dienyl]-2-hydroxy-2H-furan-5-one4-[(3E,7E)-4,8-Dimethyl-10-(2,6,6-trimethyl-1-cyclohexenyl)-3,7-decadienyl]-5-hydroxyfuran-2(5H)-one4-[(3E,7E)-4,8-Dimethyl-10-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3,7-decadienyl]-5-hydroxy-2(5H)-furanone2(5H)-Furanone, 4-[(3E,7E)-4,8-dimethyl-10-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3,7-decadien-1-yl]-5-hydroxy-
데이터베이스 식별자
- CAS
111149-87-2- PubChem CID
- 5387248
- DTXSID
DTXSID901351916- ChEMBL
CHEMBL451037- ChEBI
CHEBI:181926- Nikkaji
- J247.990G
물성
물리화학적 성질
- 끓는 점
- 541.7 · 541.7±50.0 °C(Predicted)
- 밀도
- 1.006 · 1.006±0.06 g/cm3(Predicted)
- 용해도
- DMSO: soluble; Ethanol: soluble
- 산도 계수 (pKa)
- 9.98 · 9.98±0.40(Predicted)
- 물리적 상태
- 연한 노란색 오일.
- InChI
- InChI=1S/C25H38O3/c1-18(11-7-13-21-17-23(26)28-24(21)27)9-6-10-19(2)14-15-22-20(3)12-8-16-25(22,4)5/h10-11,17,24,27H,6-9,12-16H2,1-5H3/b18-11+,19-10+
- InChIKey
- JPWPYTMXSXYUPG-QZPYEDBESA-N
- SMILES
- O1C(O)C(CC/C=C(\C)/CC/C=C(\C)/CCC2C(C)(C)CCCC=2C)=CC1=O
화학 및 산업
응용 분야
용도Luffariellolide is a natural sesterterpenoid which reversibly inhibits secretory phospholipase A2 isoforms from bee venom (IC50 = 230 nM) and snake venom, reducing inflammation. It blocks the production of platelet-activating factor in stimulated neutrophils (IC50 = 5 μM). Luffariellolide is also a structural mimic of all-trans retinoic acid (RA) and, at 1 μM, acts as an agonist for the RA receptors RAR α, β, and γ but not for other nuclear receptors. In RA-sensitive cancer cell lines, luffariellolide induces the expression of RAR target genes and inhibits cell growth. It also inhibits the activation of hypoxia-inducible factor by hypoxia (IC50 = 3.6 μM).[Cayman Chemical]
공급사17 곳
咸宁深蓝生物医药研发有限公司18171815831 · [email protected]
Aladdin Scientific[email protected]
欧利希（湖北）医药科技有限公司17316404525 17316404525 · [email protected]
MedBio脉铂医药021-69568360 18916172912 · [email protected]
上海尺水药物研究有限公司[email protected] 13564957716 · [email protected]
深圳振强药物研发有限公司+86-0755-66853366 +86-13670046396 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
安耐吉化学&3A（安徽泽升科技股份有限公司）400-0056266 · [email protected]
南通全益生物科技有限公司0513-66337626 18051384581 · [email protected]
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