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기본 정보
- CAS
80125-14-0- 표준 SMILES
CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC- InChIKey
GUJRSXAPGDDABA-NSHDSACASA-N- 분자식
- C16H23BrN2O3
- 평균 분자량
- 371.275 g/mol
- 단동위원소 질량
- 370.0892047
이름 및 식별자
- 우선 이름
- Remoxipride
- IUPAC
- 3-Bromo-N-{[(2S)-1-ethylpyrrolidin-2-yl]methyl}-2,6-dimethoxybenzamide
- 현지명
- 레목시프리드
- 영어명
- Remoxipride
- 분자식
- C16H23BrN2O3
- 분자량
- 371.27
이름 및 동의어
레목시프리드RoxiamFLA-731A-33547REMOXIPRIDE(S)-RemoxiprideRemoxipride [USAN:BAN:INN](S)-3-Bromo-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2，6-dimethoxybenzamide(S)-3-BroMo-N-((1-ethylpyrrolidin-2-yl)Methyl)-2,6-diMethoxybenzaMide3-Bromo-2,6-dimethoxy-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]benzamide3-Bromo-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2,6-dimethoxybenzamide
데이터베이스 식별자
- CAS
80125-14-0- PubChem CID
- 54477
- DTXSID
DTXSID6045668- ChEMBL
CHEMBL22242- ChEBI
CHEBI:92948- UNII
- 0223RD59PE
- Nikkaji
- J138.394I
물성
물리화학적 성질
- 끓는 점
- 439.9 · 439.9±45.0 °C(Predicted)
- 밀도
- 1.292 · 1.292
- 저장 조건
- 2 · 2-8°C
- 산도 계수 (pKa)
- 8.9 · pKa 8.9 (Uncertain)
- NIST
- Remoxipride(80125-14-0)
화학 및 산업
응용 분야
용도Antipsychotic.
일반 설명Remoxipride is a D2 receptorblocker.It is as effective as haloperidol with fewer EPS andautonomic side effects. Negative symptoms of schizophreniaare diminished. The drug is classed as an atypical antipsychotic.Life-threatening aplastic anemia was reported with itsuse, which prompted its withdrawal from the market.With respect to the atypical antipsychotics, two eventslong in the past may shed some light on the events of today.The field of reuptake-inhibiting antidepressants arose whenonly a very small structural change was made in an antipsychoticdrug, and the new activity noted. (The antipsychoticactivity remained.) Therefore, small changes in structurecan produce antipsychotics that are active against depressivesymptoms. Likewise, small changes in structure could provideselectivity among D2 receptors.
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