Phosphonoacetic Acid
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4408-78-0O=C(O)CP(=O)(O)OXUYJLQHKOGNDPB-UHFFFAOYSA-NPhosphonoacetic acid is a member of the class of phosphonic acids that is phosphonic acid in which the hydrogen attached to the phosphorous is replaced by a carboxymethyl group. It has a role as an EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor and an antiviral agent. It is a monocarboxylic acid and a member of phosphonic acids. It is functionally related to an acetic acid and a phosphonic acid. It is a conjugate acid of a hydrogen phosphonatoacetate(2-).
4408-78-0DTXSID2045107CHEMBL136061、CHEMBL50300CHEBI:15732143-146 °C
143 - 146 °C
White crystalline powder; Odorless and hygroscopic; [Alfa Aesar MSDS]
Solid
134.5 Ų [M+Na]+ [CCS Type: DT; Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]
134.4 Ų [M+Na]+
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
Danger
H302 (88.6%): Harmful if swallowed [Warning Acute toxicity, oral]
P260, P264, P270, P280, P301+P317, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P321, P330, P363, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 44 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
1.2 [mg/m3]
13 [mg/m3]
79 [mg/m3]
J - Antiinfectives for systemic use
QJ - Antiinfectives for systemic use
Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
Inhibitors of reverse transcriptase (RNA-DIRECTED DNA POLYMERASE), an enzyme that synthesizes DNA on an RNA template.
용도Phosphonoacetic acid inhibits deoxyribo nucleic acid polymerase, especially in viruses. It is used as an antiviral agent. Further, it is used in the preparation of 1-(dimethylamino)-2,2-bis[(dimethylimmonio)-methyl]ethene diperchlorate by reacting with phosphorus oxychloride.
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White powder
정의ChEBI: A member of the class of phosphonic acids that is phosphonic acid in which the hydrogen attached to the phosphorous is replaced by a carboxymethyl group.