Cefpirome

CEFPIROME SULPHATE · HR-810 · Keitim · CS-283 · CEFPIROME · Cefpiroma · Cefpiromum · Cerfpirome

https://huagongshe.com/ko/chemical/5479539

식별자 및 물리적 특성

CAS No.	84957-29-9
분자식	C22H22N6O5S2
평균 분자량	514.6 g/mol
단동위원소 질량	514.1093098 g/mol
SMILES	CO/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)[O-])=C(C[n+]3cccc4c3CCC4)CS[C@H]12)c1csc(N)n1
InChIKey	DKOQGJHPHLTOJR-WHRDSVKCSA-N
PubChem CID	5479539
ChEMBL	CHEMBL65794
ChEBI	CHEBI:3503
DTXSID	DTXSID2048244

화학 및 물리적 성질

XLogP	0.9
극성 표면적	207
수소 결합 공여자 수	2
수소 결합 수용자 수	10
회전 가능 결합 수	6
무거운 원자 수	35
형식 전하	0
복잡도	955
의약품	Pharmaceuticals -> Antibiotics
저장 조건	2-8°C(protect from light)

안전 및 규제

Drug Induced Liver Injury	Drug-Induced Liver Injury Severity and Toxicity (DILIst)CefpiromeDILI PositiveDOI:10.1016/j.drudis.2019.09.022
독성	LD50 in mice, rats (g/kg): 1.9-2.4, 1.9-2.15 i.v.3.8-4.2, 5.8-6.55 i.p. (Donaubauer, Mayer)
위험 문구(R)	36/37/38-42/43
위험 표시	Xi
안전 문구(S)	22-26-36/37/39

용도

개요

This drug is resistant with respect to a broad spectrum of beta-lactamases. Its spectrum of activity is analogous to that of the third-generation cephalosporin cefotaxime (32.1.2.56), although it is more active with respect to some staphylococci, enterococci, and also a few enterobacteria. Synonyms of this drug are cefrom, cedixen, and others.

용도

Cephalosporin antibiotic Claforan