기본 정보
- CAS
482-38-2- 표준 SMILES
C[C@@H]1O[C@@H](Oc2cc(O)c3c(=O)c(O[C@@H]4O[C@@H](C)[C@H](O)[C@@H](O)[C@H]4O)c(-c4ccc(O)cc4)oc3c2)[C@H](O)[C@H](O)[C@H]1O- InChIKey
PUPKKEQDLNREIM-QNSQPKOQSA-N- 분자식
- C27H30O14
- 평균 분자량
- 578.5 g/mol
- 단동위원소 질량
- 578.16355563
개요
Kaempferol 3,7-di-O-alpha-L-rhamnoside is a glycosyloxyflavone that is kaempferol attached to alpha-L-rhamnopyranosyl residues at positions 3 and 7 respectively via glycosidic linkages. It has been isolated from the aerial parts of Vicia faba and Lotus edulis. It has a role as an antidepressant, a hypoglycemic agent, an antineoplastic agent, a bone density conservation agent, an immunomodulator, an anti-inflammatory agent, an apoptosis inducer and a plant metabolite. It is a polyphenol, an alpha-L-rhamnoside, a dihydroxyflavone, a glycosyloxyflavone and a monosaccharide derivative. It is functionally related to a kaempferol.
이름 및 식별자
- 우선 이름
- Kaempferitrin
- IUPAC
- 5-hydroxy-2-(4-hydroxyphenyl)-3,7-bis[[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy]chromen-4-one
- 영어명
- KAEMPFERITRIN
- 분자식
- C27H30O14
- 분자량
- 578.52
이름 및 동의어
Kaempferitrin482-38-2LespenefrilKaempferol 3,7-dirhamnosidelespenephrilKaempferol 3,7-bisrhamnosideKaempferol-dirhamnosideVPV01U3R59DTXSID901974584H-1-Benzopyran-4-one, 3,7-bis((6-deoxy-alpha-L-mannopyranosyl)oxy)-5-hydroxy-2-(4-hydroxyphenyl)-3,7-Bis((6-deoxy-alpha-L-mannopyranosyl)oxy)-5-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one5-hydroxy-2-(4-hydroxyphenyl)-3,7-bis[[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy]chromen-4-one
이름 더 보기
Kaempherol 3,7-bismannosideKAEMPFERITRIN(P)Kaempferitrin-RMKaempferitrin (LespedinKaeMpferol3,7bisrhaMnosideKAEMPFEROL-3,7-DIRHAMNOSIDE
3,7-Bis[(6-deoxy-alpha-L-mannopyranosyl)oxy]-5-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one3,7-bis-(alpha-6-deoxymannopyranosyloxy)-5-hydroxy-2-(4-hydroxyphenyl)chromen-4-one5-hydroxy-2-(4-hydroxyphenyl)-3,7-bis(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl)oxy)chromen-4-oneRefChem:40778DTXCID00119949LespedinLespenephrylgrosvenorine II
물성
구조 계산 물성
- XLogP
- -0.1
- 극성 표면적
- 225 Ų
- 수소 결합 공여자 수
- 8
- 수소 결합 수용자 수
- 14
- 회전 가능 결합 수
- 5
- 무거운 원자 수
- 41
- 형식 전하
- 0
- 복잡도
- 968
실험 및 물리화학적 성질
LipidsPolyketides [PK] -> Flavonoids [PK12] -> Flavones and Flavonols [PK1211]
Melting Point202 - 203 °C
Physical DescriptionSolid
물리화학적 성질
- 녹는점
- 202 · 202~203℃
- 끓는 점
- 908.6 · 908.6±65.0 °C(Predicted)
- 밀도
- 1.7 · 1.70
- 저장 조건
- -20 °C · -20°C
- 용해도
- 125 mg/mL · DMSO : 125 mg/mL (216.07 mM; Need ultrasonic)
- 산도 계수 (pKa)
- 5.81 · 5.81±0.40(Predicted)
- 물리적 상태
- 가루
- 색상
- 흰색에서 베이지색
- 생물학적 소스
- (Cinnamomum sp.)
- 안정성
- 흡습성
- 주요 응용
- 음식 및 음료
- InChIKey
- PUPKKEQDLNREIM-QNSQPKOQSA-N
- SMILES
- OC(C=C1)=CC=C1C2=C(O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](O)[C@H]3O)C(C4=C(O)C=C(O[C@@H]5O[C@@H](C)[C@H](O)[C@@H](O)[C@H]5O)C=C4O2)=O
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
안전 데이터
- wgk
- WGK 3
- HS 번호
- 29389090
- safety_code
- 24/25
- 스토리지 클래스
- 11 - Combustible Solids
화학 및 산업
약리 정보
Cellular LocationsCytoplasm
응용 분야
개요Kaempferitrin is a flavonoid glycoside that has been found in B. pinnatum and has diverse biological activities. It scavenges DPPH radicals (IC50 = 8.73 μg/ml) and is active against the bacteria S. aureus, P. aeruginosa, and S. typhi, as well as the fungi C. albicans, C. parapsilosis, and C. neoformans (MICs = 16-32 μg/ml). Kaempferitrin inhibits LPS-and IFN-γ-induced nitric oxide (NO) production in isolated mouse macrophages (IC50 = 40 μM). It decreases blood glucose levels in a rat model of alloxan-induced diabetes when administered at a dose of 100 mg/kg.
용도Kaempferitirin is a glycoside of Kaempferol (K100000), a plant flavonoid that exhibits antioxidant properties and is known to reduce risks of various types cancer and cardiovascular diseases. Kaempferitirin have been isolated as natural products from plants such as Hedyotis Verticilata.
일반 설명This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
공급사100 곳
北京华美互利生物化工010-56205725 · [email protected]
成都普瑞法科技开发有限公司+86-028-82633397 18982077548 · [email protected]
成都曼思特生物科技有限公司18010516991 · [email protected]
南京普怡生物科技有限公司13814510036 · [email protected]
成都埃法生物科技有限公司028-028-85142057 19983342022 · [email protected]
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