CAS 14024-61-4 Palladium acetylacetonate (HCID 5486778)

이름 및 식별자

우선 이름: Palladium acetylacetonate
IUPAC: bis((Z)-4-oxopent-2-en-2-olate);palladium(2+)
영어명: Bis(2,4-pentanedionato-O,O')palladium(II)
분자식: C10H14O4Pd
분자량: 304.64

이름 및 동의어

14024-61-4RefChem:858315PALLADIUM(2+) ION BIS(4-OXOPENT-2-EN-2-OLATE)Palladium acetylacetonatePalladium(II) acetylacetonatePalladium bis(acetoacetonate)Pd(acac)2Bis(acetylacetonato)palladium(Z)-4-oxopent-2-en-2-olate;palladium(2+)Palladium-2,4-pentanedionatePalladium, bis(2,4-pentanedionato-kappaO2,kappaO4)-, (SP-4-1)-palladium (II) acetylacetonate

이름 더 보기

BIS(ACETYLACETONATO)PALLADIUM(II)ACETYLACETONE PALLADIUM(II) SALTBIS(2,4-PENTANEDIONATO)PALLADIUM(II)ACETYLACETONE, PALLADIUM(II) DERIVATIVE34.7%PdUmicore, 99%Palladium acet

EINECS 237-859-8Palladium, bis(2,4-pentanedionato)-NSC 187660Palladium (II) di(4-oxopent-2-en-2-oate)palladium(II)acetylacetonate6G7QUC3M5JSCHEMBL144097Palladium, bis(2,4-pentanedionato-O,O')-, (SP-4-1)-

데이터베이스 식별자

CAS: 14024-61-4
PubChem CID: 5486778
UNII: 6G7QUC3M5J
EC Number: 237-859-8

물성

구조 계산 물성

극성 표면적: 80.3 Å²
수소 결합 공여자 수: 0
수소 결합 수용자 수: 4
회전 가능 결합 수: 2
무거운 원자 수: 15
형식 전하: 0
복잡도: 90

물리화학적 성질

녹는점: 190 °C · 190 °C
끓는 점: 300 °/0.1mm · 300°/0.1mm
증기압: 0 Pa · 0Pa at 25℃
저장 조건: 30 °C · Store below +30°C.
용해도: 벤젠과 클로로포름에 용해됩니다.
물리적 상태: 액체
색상: 노란색에서 주황색으로
Specific Gravity: 1.862 · 1.862
수용성: 불용성
BRN: 4136188 · 4136188
InChI: InChI=1S/2C5H8O2.Pd/c2*1-4(6)3-5(2)7;/h2*3,6H,1-2H3;/q;;+2/p-2/b2*4-3-;
InChIKey: RJJXYEQOOACRKP-LNKPDPKZSA-M
SMILES: O([Pd]O/C(/C)=C\C(=O)C)/C(/C)=C\C(=O)C
LogP: 2.6 at · 2.6 at 25℃
NIST: Bis(acetylacetonato)palladium(14024-61-4)
EPA: Palladium, bis(2,4-pentanedionato-.kappa.O,.kappa.O')-, (SP-4-1)- (14024-61-4)

화학적 성질

yellow orange needles

안전 및 규제

GHS 분류

GHS Classification · 5건

Danger

H228 (61.5%): Flammable solid [Danger Flammable solids]；H251 (26.6%): Self-heating; may catch fire [Danger Self-heating substances and mixtures]；H302 (25.7%): Harmful if swallowed [Warning Acute toxicity, oral]；H315 (36.7%): Causes skin irritation [Warning Skin corrosion/irritation]；H317 (24.8%): May cause an allergic skin reaction [Warning Sensitization, Skin]；H318 (24.8%): Causes serious eye damage [Danger Serious eye damage/eye irritation]；H319 (73.4%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]；H335 (34.9%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]；H400 (24.8%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]；H410 (24.8%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

P210, P235, P240, P241, P261, P264, P264+P265, P270, P271, P272, P273, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P330, P332+P317, P333+P317, P337+P317, P362+P364, P370+P378, P391, P403+P233, P405, P407, P410, P413, P420, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 109 reports by companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

유해성 정보

Regulatory Information · 3건

Chemical: Palladium, bis(2,4-pentanedionato-O,O')-, (SP-4-1)-

Status: Active Update: 25-11-2020 https://echa.europa.eu/registration-dossier/-/registered-dossier/18885

Palladium, bis(2,4-pentanedionato-.kappa.O,.kappa.O')-, (SP-4-1)-: Does not have an individual approval but may be used under an appropriate group standard

Other Safety InformationIMAP assessments - Palladium, bis(2,4-pentanedionato-O,O')-, (SP-4-1)-: Human health tier I assessment；IMAP assessments - Palladium, bis(2,4-pentanedionato-O,O')-, (SP-4-1)-: Environment tier I assessment

Hazard Classes and CategoriesFlam. Sol. 1 (61.5%)；Self-heat. 1 (26.6%)；Acute Tox. 4 (25.7%)；Skin Irrit. 2 (36.7%)；Skin Sens. 1 (24.8%)；Eye Dam. 1 (24.8%)；Eye Irrit. 2 (73.4%)；STOT SE 3 (34.9%)；Aquatic Acute 1 (24.8%)；Aquatic Chronic 1 (24.8%)

독성 정보

Health Effects · 2건

Contact with palladium may cause palladium sensitivity and allergy. Animal studies have shown that palladium may damage the liver and kidney. (L798)

Toxicity Summary · 2건

Due to their ability to form strong complexes with both inorganic and organic ligands, palladium ions can disturb cellular equilibria, replace other essential ions, and interact with functional groups of macromolecules, such as proteins or DNA. Palladium complexes binding to DNA and RNA leads to strand breakage. Palladium ions are able to inhibit most major cellular functions, including DNA and RNA synthesis. Palladium compounds have been shown to bind to and inhibit various enzymes, including creatine kinase and prolyl hydroxylase. (L798)

Signs and Symptoms · 2건

Skin contact with palladium may cause contact dermatitis, erythema, and oedema. (L798)

Carcinogen Classification · 2건

No indication of carcinogenicity to humans (not listed by IARC).

규제 정보

Regulatory Information · 3건

Chemical: Palladium, bis(2,4-pentanedionato-O,O')-, (SP-4-1)-

Status: Active Update: 25-11-2020 https://echa.europa.eu/registration-dossier/-/registered-dossier/18885

Palladium, bis(2,4-pentanedionato-.kappa.O,.kappa.O')-, (SP-4-1)-: Does not have an individual approval but may be used under an appropriate group standard

안전 데이터

wgk: 2
tsca: TSCA listed
ridadr: 3181
HS 번호: 28439090
risk_code: 36-36/37/38-22
hazard_code: Xi,Xn
safety_code: 26-37/39
Hazard Classifications: Eye Irrit. 2
스토리지 클래스: 11 - Combustible Solids

화학 및 산업

약리 정보

Metabolism/Metabolites · 2건

Palladium may be absorbed through oral, dermal, and inhalation exposure. Once in the body it distributes to the kidney, liver, spleen, lymph nodes, adrenal gland, lung and bone. Palladium's ability to form complexes allows it the bind to amino acids, proteins, DNA, and other macromolecules. Palladium and its metabolites are excreted in the urine and faeces. (A21)

용도 및 제조

General Manufacturing InformationPalladium, bis(2,4-pentanedionato-.kappa.O2,.kappa.O4)-, (SP-4-1)-: ACTIVE

응용 분야 · 2건

용도Palladium(II) Acetylacetonate is an active anticancer agent. Exhibits growth inhibitory effect more than cisplatin in several cancer cells and treatment with Palladium(II) Acetylacetonate inhibits H460 cells. Palladium(II) Acetylacetonate is a catalyst for various organic transformations.

일반 설명Palladium(II) acetylacetonate (Pd(acac)2) is a metal-organic complex. Sublimation of Pd(acac)2 has been investigated by thermogravimetry and XRD. The temperature range for the sublimation of Pd(acac)2, without undergoing thermal decomposition, was determined to be 100-160°C in the presence of inert gas helium.