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기본 정보
- CAS
70280-03-4- 표준 SMILES
CC(=O)N[C@H]1[C@H](O[C@@H]([C@H](O[C@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](CCC(=O)O)C(N)=O)[C@H](C=O)NC(C)=O)[C@H](O)CO)O[C@H](CO)[C@@H](O)[C@@H]1O- InChIKey
JPBBNLWRCVBGJS-KCAUTNRHSA-N- 분자식
- C27H45N5O16
- 평균 분자량
- 695.676 g/mol
- 단동위원소 질량
- 695.28613036
이름 및 식별자
- 우선 이름
- 3-O-[1-({1-[(4-Carboxy-1-hydroxy-1-iminobutan-2-yl)imino]-1-hydroxypropan-2-yl}imino)-1-hydroxypropan-2-yl]-2-deoxy-4-O-{2-deoxy-2-[(1-hydroxyethylidene)amino]hexopyranosyl}-2-[(1-hydroxyethylidene)amino]hexose
- IUPAC
- 3-O-[(2R)-1-{[(2S)-1-{[(2R)-4-Carboxy-1-hydroxy-1-iminobutan-2-yl]imino}-1-hydroxypropan-2-yl]imino}-1-hydroxypropan-2-yl]-2-deoxy-4-O-{2-deoxy-2-[(1-hydroxyethylidene)amino]-beta-D-glucopyranosyl}-2-[(1-hydroxyethylidene)amino]-D-glucose
- 현지명
- N-아세틸-D-글루코사미닐-(BETA1,4)-N-아세틸무라밀-L-알라닐-D-이소글루타민
- 영어명
- GMDP
- 분자식
- C27H45N5O16
- 분자량
- 695.67
이름 및 동의어
N-아세틸-D-글루코사미닐-(BETA1,4)-N-아세틸무라밀-L-알라닐-D-이소글루타민GMDPsyl)muramoyl)-l-alanyl-glucosaminylmuramyldipeptide4-(2-ACETAMIDO-2-DEOXY-B-D- &4-(2-acetamido-2-deoxy-B-D-*glucopyranosyl)-N-aced-glcnac-β-(1→4)-n-acetylmuramyl-l-ala-d-isoglutamineD-GLCNAC-BETA-(1->4)-N-ACETYLMURAMYL-L-ALA-D-ISOGLUTAMINEN-Acetyl-D-glucosaminyl-(b1,4)-N-acetylmuramyl-L-alanyl-D-ion-acetylglucosaminyl-n-acetylmuramyl-l-alanyl-d-isoglutaminen-acetyl-beta-glucosaminyl-n-acetylmuramyl-alanylisoglutamine
데이터베이스 식별자
- CAS
70280-03-4- PubChem CID
- 5486810
- DTXSID
DTXSID70990489- ChEBI
CHEBI:135873
물성
물리화학적 성질
- 끓는 점
- 1270.07 · 1270.070±65.00 °C(Press: 760.00 Torr)(predicted)
- 밀도
- 1.476 · 1.476±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
- 저장 조건
- 20 °C · −20°C
- 산도 계수 (pKa)
- 4.442 · 4.442±0.10(predicted)
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
안전 데이터
- wgk
- 3
- rtecs
- MA2275230
- risk_code
- 20/21/22
- hazard_code
- Xn
- safety_code
- 36/37
화학 및 산업
응용 분야
개요N-acetyl-β-D-glucosaminyl-( 1→4)-N-acetylmuramyl-L-alanyl-D-isoglutamine was launched in Russia for hospital-related infections, psoriasis, cervical precancerous lesions and ophthalmic keratitis caused by herpes. It was found to be less pyrogenic than MDP, the minimally active component of Freund's complete adjuvant. While chemical synthesis is possible, a less laborious method (3 steps) involves the enzymatic degradation of a bacterial peptidoglycan. GDMP is orally active with a low toxicity that acts as an adjuvant to highly purified protein antigens to stimulate the induction of CD8* T-cell response. It was also able to reduce the levels of TNF-α, IL-1α and hypoglycemia induced by LPS administration and to inhibit systemic response to endotoxin.
공급사3 곳
深圳振强药物研发有限公司0755-66853366 13670046396 · [email protected]
常州翔龙医药科技有限公司18915873328 18915873328 · [email protected]
南京肽业生物科技有限公司025-58361106-805 15951641583 · [email protected]
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