기본 정보
- CAS
70967-90-7- 표준 SMILES
COC(=O)CCC(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NC(=O)[C@@H](Nc1ccc([N+](=O)[O-])cc1)C(C)C- InChIKey
JWYKDZIEIWGSBN-OSAZLGQLSA-N- 분자식
- C27H38N6O9
- 평균 분자량
- 590.6 g/mol
- 단동위원소 질량
- 590.27002681
이름 및 식별자
- 우선 이름
- N-methoxysuccinyl-alanyl-alanyl-prolyl-valine-4-nitroanilide
- IUPAC
- methyl 4-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S)-3-methyl-2-(4-nitroanilino)butanoyl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-oxobutanoate
- 영어명
- N-METHOXYSUCCINYL-ALA-ALA-PRO-VAL P-NITROANILIDE
- 분자식
- C27H38N6O9
- 분자량
- 590.63
이름 및 동의어
Meo-suc-ala-ala-pro-val-NAN-Methoxysuccinyl-alanyl-alanyl-prolyl-valine-4-nitroanilideN-Methoxysuccinyl-alanyl-alanyl-prolyl-valine-p-nitroanilideRefChem:163662N-methoxysuccinyl-Ala-Ala-Pro-Val-pNA70967-90-7Aapv-NAmethyl 4-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S)-3-methyl-2-(4-nitroanilino)butanoyl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-oxobutanoateSCHEMBL29144618DTXSID30991270N-(4-Methoxy-1,4-dioxobutyl)-L-alanyl-L-alanyl-L-prolyl-N-(4-nitrophenyl)-L-valinamide(2S)-1-(N-{(2S)-1-Hydroxy-2-[(1-hydroxy-4-methoxy-4-oxobutylidene)amino]propylidene}-L-alanyl)-N-[N-(4-nitrophenyl)-L-valyl]pyrrolidine-2-carboximidic acid
이름 더 보기
MEOSUC-ALA-ALA-PRO-VAL-PNAM4765MeOSuc-AAPV-pNALEUKOCYTE ESTERASE SUBSTRATEELASTASE SUBSTRATE I, COLORIMETRICMeOSuc-AAPV-pNA, Chromogenic SubstrateMEO-SUC-ALA-ALA-PRO-VAL-PARANITROANILIDEMETHOXYSUCCINYL-ALA-ALA-PRO-VAL-P-NITROANILIDE
물성
구조 계산 물성
- XLogP
- 1.5
- 극성 표면적
- 209 Ų
- 수소 결합 공여자 수
- 4
- 수소 결합 수용자 수
- 10
- 회전 가능 결합 수
- 13
- 무거운 원자 수
- 42
- 형식 전하
- 0
- 복잡도
- 1,020
물리화학적 성질
- 녹는점
- 203 · 203-205°C
- 끓는 점
- 958.4 · 958.4±65.0 °C(Predicted)
- 밀도
- 1.297 · 1.297±0.06 g/cm3(Predicted)
- 저장 조건
- -20 °C · -20°C
- 용해도
- 25 mg/mL, · DMF: 25mg/mL, 투명, 연황색
- 물리적 상태
- 회백색 고체
- 산도 계수 (pKa)
- 13.29 · 13.29±0.20(Predicted)
- 색상
- 흰색에서 황백색까지
- 수용성
- 1 mg/mL · water: 1mg/mL
- BRN
- 6266359 · 6266359
- InChIKey
- YEGSVRNITOBIRO-OSAZLGQLSA-N
- SMILES
- C(N)(=O)[C@H](C(C)C)N(C(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)CCC(OC)=O)C1=CC=C([N+]([O-])=O)C=C1
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
유해성 정보
Regulatory Information
L-Valinamide, N-(4-methoxy-1,4-dioxobutyl)-L-alanyl-L-alanyl-L-prolyl-N-(4-nitrophenyl)-: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
안전 데이터
- wgk
- 3
- safety_code
- 22-24/25
- F 고인화성물질
- 10-21
- 스토리지 클래스
- 11 - Combustible Solids
화학 및 산업
응용 분야
개요Proteinase 3 (PR3, myeloblastin) is a polymorphonuclear leukocyte serine proteinase that degrades matrix proteins including fibronectin, laminin, vitronectin, and collagen type IV to generate antimicrobial peptides. Neutrophil elastase is a serine proteinase that is secreted by neutrophils during inflammation to destroy pathogens. Evaluating these enzymes is helpful to understanding inflammatory autoimmune processes. MeOSuc-AAPV-pNA is a highly sensitive peptide substrate that is hydrolyzed by both human and mouse neutrophil elastase and PR3, but not cathepsin G or chymotrypsin. Enzyme activity can be quantified by colorimetric detection of free p-nitroanilide at 405 nm.
용도N-Methoxysuccinyl-Ala-Ala-Pro-Val p-Nitroanilide is a highly sensitive peptide substrate that is hydrolyzed by both human and mouse neutrophil elastase and PR3 but not cathespin.
공급사75 곳
湖南韵邦生物科技股份有限公司0731-88532326 13319508186 · [email protected]
杭州品高化工有限公司0571-87658025 · [email protected]
上海优宁维生物科技股份有限公司15921930842 15921930842 · [email protected]
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
南京昱盛康生物科技有限公司13327808530 · [email protected]
上海鸿肽生物科技有限公司15318089928 · [email protected]
武汉易泰科技有限公司上海分公司18930552037 · [email protected]
安耐吉化学&3A（安徽泽升科技有限公司）021-58432009 400-005-6266 · [email protected]
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