기본 정보
- CAS
82747-56-6- 표준 SMILES
Cc1ncc2c(c1O)COC2c1ccc(Cl)cc1.Cl- InChIKey
QLMBAIRFQQLJJX-UHFFFAOYSA-N- 분자식
- C14H13Cl2NO2
- 평균 분자량
- 298.2 g/mol
- 단동위원소 질량
- 297.032334
개요
Cicletanine Hydrochloride is the hydrochloride salt of a dihydropyridine derivative with diuretic and antihypertensive activity. Cicletanine exerts thiazide-like diuretic activity. In addition, this agent inhibits protein kinase C (PKC) and is able to reverse vasoconstriction through the inhibition of PKC-mediated inhibition of Na/K-ATPase phosphorylation.
이름 및 식별자
- 우선 이름
- Cicletanine Hydrochloride
- IUPAC
- 3-(4-chlorophenyl)-6-methyl-1,3-dihydrofuro[3,4-c]pyridin-7-ol;hydrochloride
- 현지명
- 시클레타닌염산염
- 영어명
- Cicletanine hydrochloride
- 분자식
- C14H12ClNO2.ClH
- 분자량
- 298.168
이름 및 동의어
CICLETANINE HYDROCHLORIDE82747-56-6Cicletanine HClT0SY6373OQWIN-90000 HCLWIN 90,000 HCLFuro(3,4-c)pyridin-7-ol, 3-(4-chlorophenyl)-1,3-dihydro-6-methyl-, hydrochlorideRefChem:1261013-(4-chlorophenyl)-6-methyl-1,3-dihydrofuro[3,4-c]pyridin-7-ol;hydrochloride3-(4-chlorophenyl)-6-methyl-1,3-dihydrofuro[3,4-c]pyridin-7-ol hydrochlorideCicletanine hydrochloride (JAN)Coverine
이름 더 보기
시클레타닌염산염JustarSecletanTenstaten3-(4-Chlorophenyl)-1,3-dihydro-6-methyl-furo[3,4-c]pyridin-7-ol Hydrochloride3-(4-chlorophenyl)-6-methyl-1,3-dihydrofuro[3,4-c]pyridin-7-ol hydrochloride (1:1)
3-(4-chlorophenyl)-6-methyl-1H,3H-furo[3,4-c]pyridin-7-ol hydrochlorideCICLETANINE HYDROCHLORIDE [JAN]Furosemide Impurity 22UNII-T0SY6373OQTenstaten (TN)Justar (TN)BN 1270SCHEMBL387011
데이터베이스 식별자
물성
구조 계산 물성
- 극성 표면적
- 42.4 Ų
- 수소 결합 공여자 수
- 2
- 수소 결합 수용자 수
- 3
- 회전 가능 결합 수
- 1
- 무거운 원자 수
- 19
- 형식 전하
- 0
- 복잡도
- 294
물리화학적 성질
- 녹는점
- 208 · 208-219°C
- 저장 조건
- Refrigerator
- 용해도
- 메탄올에 용해됨
- 물리적 상태
- 고체
- 색상
- 분홍색
화학적 성질
Pink Solid
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
This chemical does not meet GHS hazard criteria for 50% (1 of 2) of reports.
Warning
H315 (50%): Causes skin irritation [Warning Skin corrosion/irritation]
P264, P264+P265, P280, P302+P352, P305+P351+P338, P321, P332+P317, P337+P317, and P362+P364 (click each P-code to see the statement)
Aggregated GHS information provided per 2 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
유해성 정보
Hazard Classes and CategoriesSkin Irrit. 2 (50%)
안전 데이터
- 신호 어
- Warning
- 유해·위험 문구
- 암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드 H315
화학 및 산업
약리 정보
MeSH Pharmacological Classification
Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.
Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
Agents that promote the excretion of urine through their effects on kidney function.
응용 분야
개요Cicletanine is an antihypertensive diuretic indicated for the treatment of essential hypertension. Its unique mechanism of action is thought to involve the decrease of peripheral resistance and increase of venous compliance without modification of arterial diameter and venous tone. Chemically cicletanine belongs to a series of furopyridhes not associated with any currently known pharmacological classes.
공급사12 곳
Dayang Chem (Hangzhou) Co.,Ltd.+86-0571-88938639 17705817739 · [email protected]
安耐吉化学&3A（安徽泽升科技有限公司）021-58432009 400-005-6266 · [email protected]
玺标（上海）科技有限公司18512111473 18512111473 · [email protected]
Cato Research Chemicals Inc.020-81960175 · [email protected]
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