Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용

HCID 5497생성일: 2026년 10월 27일

N,N-Diethylnicotinamide

NIKETHAMIDE · Nikotin · Niketamide · CORVOTONE · Tonocard · nicor · Ni-Cor · Corivo

식별자 및 물리적 특성

CAS No.	59-26-7
분자식	C10H14N2O
평균 분자량	178.23 g/mol
단동위원소 질량	178.11061307 g/mol
SMILES	CCN(CC)C(=O)c1cccnc1
InChIKey	NCYVXEGFNDZQCU-UHFFFAOYSA-N
PubChem CID	5497
ChEMBL	CHEMBL2104607
ChEBI	CHEBI:134814
EC No.	200-418-5
DTXSID	DTXSID9046524

화학 및 물리적 성질

XLogP	0.3
극성 표면적	33.2
수소 결합 공여자 수	0
수소 결합 수용자 수	2
회전 가능 결합 수	3
무거운 원자 수	13
형식 전하	0
복잡도	166
의약품	DEA NFLIS-Drug Category -> StimulantsPharmaceuticals -> Used in Switzerland
SpringerMaterials Properties	Chemical shift
밀도	1.058 to 1.066 at 77 °F (NTP, 1992)1.06 g/mL at 25 °C (lit.)
용해도	greater than or equal to 100 mg/mL at 73 °F (NTP, 1992)클로로포름(약간 용해됨), 에틸아세테이트(약간 용해됨), 메탄올(약간 용해됨)
인화점	235 °F (NTP, 1992)>230 °F
Human Drugs	Pharmaceuticals
끓는 점	565 to 572 °F at 760 mmHg (some decomposition) (NTP, 1992)296-300 °C (lit.)
녹는점	75 to 79 °F (NTP, 1992)23 °C (lit.)
Physical Description	Nicethamid appears as clear light yellow viscous liquid or crystalline solid. Slightly bitter taste followed by a faint sensation of the warmth. (NTP, 1992)
Ionization Efficiency	Positive4.462.7Agilent XCTElectrospray ionizationformic acid (5.3nM)
굴절률	n20/D 1.524(lit.)
저장 조건	2-8°C
pKa(산도 계수)	pKa 3.46(H2O,t =20) (Uncertain)
물리적 상태	액체
색상	무색~황색으로 투명함
Merck	14,6543
BRN	5743
InChI	InChI=1S/C10H14N2O/c1-3-12(4-2)10(13)9-6-5-7-11-8-9/h5-8H,3-4H2,1-2H3
InChIKey	NCYVXEGFNDZQCU-UHFFFAOYSA-N
SMILES	C1=NC=CC=C1C(N(CC)CC)=O
EPA	Nikethamide (59-26-7)

화학적 성질

clear colorless to yellow liquid

안전 및 규제

GHS 분류	DangerH301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]P261, P264, P264+P265, P270, P271, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 85 reports by companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
규제 정보	Status: Active Update: 02-10-2019 https://echa.europa.eu/registration-dossier/-/registered-dossier/196763-Pyridinecarboxamide, N,N-diethyl-: Does not have an individual approval but may be used under an appropriate group standard
운송 라벨(DOT)	Poison
화재 위험	This chemical is combustible. (NTP, 1992)
건강 유해성	ACUTE/CHRONIC HAZARDS: When heated to decomposition this compound emits toxic fumes. (NTP, 1992)
반응성 그룹	Amides and Imides
Reactivity Profile	NICETHAMID is incompatible with sodium carbonate solutions which cause precipitation. (NTP, 1992).
Air and Water Reactions	Water soluble.
Hazard Classes and Categories	Acute Tox. 3 (100%)
소화	Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)
응급 처치	EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.
비화재 누출 대응	SMALL SPILLS AND LEAKAGE: If you should spill this chemical, use absorbent paper to pick up all liquid spill material. Seal the absorbent paper, as well as any of your clothing which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Wash any surfaces you may have contaminated with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

용도

개요

A further Corydalis alkaloid, coramine has been obtained from C. pseudoadunca M. Pop. It forms colourless needles from EtOH and is optically active with a specific rotation of [α]D - 391 ° (c 0.2, MeOH). Both the hydrochloride, m.p. 216-9°C and the hydrobromide, m.p. 223-6°C have been described.

용도

analeptic

일반 설명

Clear light yellow viscous liquid or crystalline solid. Slightly bitter taste followed by a faint sensation of the warmth.

CAS No.

59-26-7

분자식

C10H14N2O

평균 분자량

178.23 g/mol

단동위원소 질량

178.11061307 g/mol

SMILES

CCN(CC)C(=O)c1cccnc1

InChIKey

NCYVXEGFNDZQCU-UHFFFAOYSA-N

PubChem CID

5497

ChEMBL

CHEMBL2104607

ChEBI

CHEBI:134814

EC No.

200-418-5

DTXSID

DTXSID9046524

화학 및 물리적 성질

XLogP

0.3

극성 표면적

33.2

수소 결합 공여자 수

수소 결합 수용자 수

회전 가능 결합 수

무거운 원자 수

형식 전하

복잡도

166

의약품

DEA NFLIS-Drug Category -> StimulantsPharmaceuticals -> Used in Switzerland

SpringerMaterials Properties

Chemical shift

밀도

1.058 to 1.066 at 77 °F (NTP, 1992)1.06 g/mL at 25 °C (lit.)

용해도

greater than or equal to 100 mg/mL at 73 °F (NTP, 1992)클로로포름(약간 용해됨), 에틸아세테이트(약간 용해됨), 메탄올(약간 용해됨)

인화점

235 °F (NTP, 1992)>230 °F

Human Drugs

Pharmaceuticals

끓는 점

565 to 572 °F at 760 mmHg (some decomposition) (NTP, 1992)296-300 °C (lit.)

녹는점

75 to 79 °F (NTP, 1992)23 °C (lit.)

Physical Description

Nicethamid appears as clear light yellow viscous liquid or crystalline solid. Slightly bitter taste followed by a faint sensation of the warmth. (NTP, 1992)

Ionization Efficiency

Positive4.462.7Agilent XCTElectrospray ionizationformic acid (5.3nM)

굴절률

n20/D 1.524(lit.)

저장 조건

2-8°C

pKa(산도 계수)

pKa 3.46(H2O,t =20) (Uncertain)

물리적 상태

액체

색상

무색~황색으로 투명함

Merck

14,6543

BRN

5743

InChI

InChI=1S/C10H14N2O/c1-3-12(4-2)10(13)9-6-5-7-11-8-9/h5-8H,3-4H2,1-2H3

InChIKey

NCYVXEGFNDZQCU-UHFFFAOYSA-N

SMILES

C1=NC=CC=C1C(N(CC)CC)=O

EPA

Nikethamide (59-26-7)

화학적 성질

clear colorless to yellow liquid

안전 및 규제

GHS 분류

DangerH301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]P261, P264, P264+P265, P270, P271, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 85 reports by companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

규제 정보

Status: Active Update: 02-10-2019 https://echa.europa.eu/registration-dossier/-/registered-dossier/196763-Pyridinecarboxamide, N,N-diethyl-: Does not have an individual approval but may be used under an appropriate group standard

운송 라벨(DOT)

Poison

화재 위험

This chemical is combustible. (NTP, 1992)

건강 유해성

ACUTE/CHRONIC HAZARDS: When heated to decomposition this compound emits toxic fumes. (NTP, 1992)

반응성 그룹

Amides and Imides

Reactivity Profile

NICETHAMID is incompatible with sodium carbonate solutions which cause precipitation. (NTP, 1992).

Air and Water Reactions

Water soluble.

Hazard Classes and Categories

Acute Tox. 3 (100%)

소화

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)

응급 처치

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

비화재 누출 대응

SMALL SPILLS AND LEAKAGE: If you should spill this chemical, use absorbent paper to pick up all liquid spill material. Seal the absorbent paper, as well as any of your clothing which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Wash any surfaces you may have contaminated with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

용도

개요

용도

analeptic

일반 설명

Clear light yellow viscous liquid or crystalline solid. Slightly bitter taste followed by a faint sensation of the warmth.