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트라이플루페리돌

Trifluperidol

HCID 5567
노트반응
기본 정보개요이름 및 식별자물성화학 및 산업관련 반응화합물 노트
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기본 정보

CAS
749-13-3
표준 SMILES
O=C(CCCN1CCC(O)(c2cccc(C(F)(F)F)c2)CC1)c1ccc(F)cc1
InChIKey
GPMXUUPHFNMNDH-UHFFFAOYSA-N
분자식
C22H23F4NO2
평균 분자량
409.4 g/mol
단동위원소 질량
409.16649162

개요

Trifluperidol is an aromatic ketone.

이름 및 식별자

우선 이름
Trifluperidol
IUPAC
1-(4-fluorophenyl)-4-[4-hydroxy-4-[3-(trifluoromethyl)phenyl]piperidin-1-yl]butan-1-one
현지명
트라이플루페리돌
영어명
trifluperidol
분자식
C22H23F4NO2
분자량
409.42

이름 및 동의어

Trifluperidol749-13-3McN-JR-2498TrifluperidoloR-2498TrifluperidolumNSC-1709781-(4-fluorophenyl)-4-[4-hydroxy-4-[3-(trifluoromethyl)phenyl]piperidin-1-yl]butan-1-oneDTXSID4023703R8869Q7R8I1-Butanone, 1-(4-fluorophenyl)-4-(4-hydroxy-4-(3-(trifluoromethyl)phenyl)-1-piperidinyl)-1-(4-Fluorophenyl)-4-(4-hydroxy-4-(3-(trifluoromethyl)phenyl)piperidin-1-yl)butan-1-one
이름 더 보기
트라이플루페리돌trifluperidol USP/EP/BP1-(4-fluorophenyl)-4-[4-hydroxy-4-[3-(trifluoromethyl)phenyl]-1-piperidyl]butan-1-one4-fluoro-4-(4-hydroxy-4-(alpha,alpha,alpha-trifluoro-m-tolyl)piperidino)butyrophenone
1-(4-fluorophenyl)-4-{4-hydroxy-4-[3-(trifluoromethyl)phenyl]piperidin-1-yl}butan-1-one1-Butanone, 1-(4-fluorophenyl)-4-[4-hydroxy-4-[3-(trifluoromethyl)phenyl]-1-piperidinyl]-RefChem:933408DTXCID903703N05AD02PsicoperidolTrisedilPsychoperidol

데이터베이스 식별자

물성

구조 계산 물성

XLogP
3.5
극성 표면적
40.5 Ų
수소 결합 공여자 수
1
수소 결합 수용자 수
7
회전 가능 결합 수
6
무거운 원자 수
29
형식 전하
0
복잡도
537

실험 및 물리화학적 성질

LogP2.27
Human DrugsPharmaceuticals

물리화학적 성질

끓는 점
515.9 · 515.9±50.0 °C(Predicted)
밀도
1.2119 · 1.2119 (estimate)
산도 계수 (pKa)
13.87 · 13.87±0.20(Predicted)

화학 및 산업

약리 정보

ATC Code · 2건

N - Nervous system

QN - Nervous system

MeSH Pharmacological Classification · 2건

Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus.

Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME.

용도 및 제조

Use ClassificationPharmaceuticals
응용 분야 · 1건

용도Trifluperidol is a powerful antipsychotic drug. It enhances the action of soporifics, narcotics, and analgesics. It also possesses anticonvulsant and antiemetic action. It is used in psychoses accompanied by motor and mental excitement, in prolonged attacks of recurrent schizophrenia, in cases accompanied by severe depression and delirium, and in alcoholic psychoses. It surpasses other neuroleptics in terms of its ability to stop minor manic excitement.

공급사11 곳

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이 페이지에서기본 정보개요이름 및 식별자물성화학 및 산업관련 반응화합물 노트
CAS
749-13-3
PubChem CID
5567
DTXSID
DTXSID4023703
ChEMBL
CHEMBL15023
ChEBI
CHEBI:135662
UNII
R8869Q7R8I
Nikkaji
J6.962K
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