기본 정보
- CAS
92812-82-3- 표준 SMILES
N[C@@H](Cc1cc(O)c(O)cc1[18F])C(=O)O- InChIKey
PAXWQORCRCBOCU-RPDRGXCHSA-N- 분자식
- C9H10FNO4
- 평균 분자량
- 214.18 g/mol
- 단동위원소 질량
- 214.06192
개요
6-((18)F)fluoro-L-dopa is a (18)F radiopharmaceutical and a 6-fluoro-L-dopa.
이름 및 식별자
- 우선 이름
- 6-(18F)fluoro-L-DOPA
- IUPAC
- (2S)-2-amino-3-(2-(18F)fluoro-4,5-dihydroxyphenyl)propanoic acid
- 현지명
- 플루오로도파
- 영어명
- Fluorodopa
- 분자식
- C9H10FNO4
- 분자량
- 215.1784032
이름 및 동의어
FLUORODOPA F 1892812-82-318F-DOPAL-6-(18F)Fluoro-DOPA18f-l-fluoro-dopaFdopa f-18(18F)FDOPA6-(18F)Fluoro-L-DOPA(18)F-dopa18F-FLUORO-DIHYDROXYPHENYLALANINEDTXSID602391573-(2-fluoro-(18)F-4,5-dihydroxyphenyl)-L-alanine
이름 더 보기
플루오로도파FDOPAFluorodopaChebi:49166((18)F)Fdopa(18F)-6-Fluoro-L-dopa6-(18F)Fluorodopamine6-((18)F)Fluoro-L-dopaFluorine-18-fluoro-L-dopa2-((18)F)Fluoro-5-hydroxy-L-tyrosine
3-(2-Fluoro-(sup 18)F-4,5-dihydroxyphenyl)-L-alanineL-Tyrosine, 2-fluoro-5-hydroxy-3,4-Dihydroxy-6-fluorophenylalanineRefChem:56270Fluorine F 18 Fluorodopa18F-FDOPADTXCID80161648fluorodopa F 18, (18)F-labeled cpd
데이터베이스 식별자
- CAS
92812-82-3- PubChem CID
- 56494
- DTXSID
DTXSID60239157
물성
구조 계산 물성
- XLogP
- -2
- 극성 표면적
- 104 Ų
- 수소 결합 공여자 수
- 4
- 수소 결합 수용자 수
- 6
- 회전 가능 결합 수
- 3
- 무거운 원자 수
- 15
- 형식 전하
- 0
- 복잡도
- 238
실험 및 물리화학적 성질
DrugsPharmaceuticals -> Various
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
독성 정보
Drug Induced Liver Injury
Drug Induced Liver Injury Rank (DILIrank 2.0)
Fluorodopa f-18
vNo-DILI-concern
0
No match
DOI:10.1016/j.drudis.2016.02.015
화학 및 산업
약리 정보
ATC Code
V - Various
QV - Various
Biological Half-LifeThe plasma half-life following intravenous administration is approximately 1-3 hours.
Metabolism/Metabolites
Fluorodopa F 18 is decarboxylated by aromatic amino acid decarboxylase (AADC) in the striatum to fluorodopamine F 18. Fluorodopamine F 18 is then further metabolized by monoamine oxidase (MAO) to yield [18F] 6-fluoro-3,4-dihydroxyphenylacetic acid, then subsequently by COMT to yield [18F]6-fluorohomovanillic acid.
Absorption, Distribution and Excretion
Approximately 80% of the administered radioactivity is eliminated in the urine.
The agent is cleared from blood and tissue within 24 hours following administration.
응용 분야
용도Diagnostic aid (brain imaging); radioactive agent. Note—This radiopharmaceutical, labeled with a cyclotron-generated radionuclide, is prepared in individual nuclear medical centers .
공급사2 곳
上海皓鸿生物医药科技有限公司400-8210725 4008210725 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354 · [email protected]
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