칼시토닌유전자관련펩타이드

Calcitonin Gene-Related Peptide

HCID 56841902

기본 정보

CAS: 56645-65-9
표준 SMILES: CC(C)C[C@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](C)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C)[C@@H](C)O)C(C)C)C(C)C)C(C)C
InChIKey: PBGNJGVTFINXOG-XJVRLEFXSA-N
분자식: C163H266N50O50S2
평균 분자량: 3,790.3 g/mol

개요

A 37-amino acid peptide derived from the calcitonin gene. It occurs as a result of alternative processing of mRNA from the calcitonin gene. The neuropeptide is widely distributed in the brain, gut, perivascular nerves, and other tissue. The peptide produces multiple biological effects and has both circulatory and neurotransmitter modes of action. In particular, it is a potent endogenous vasodilator. As a potential drug, it has demonstrated in preclinical studies a profile that could make it an ideal anti-asthmatic drug candidate with bronchodilatory, bronchoprotecting and anti-inflammatory properties.

이름 및 식별자

우선 이름: Calcitonin Gene-Related Peptide
IUPAC: (2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S,3R)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-4-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(4R,7S,10S,13S,16S,19R)-19-[[(2S)-2-aminopropanoyl]amino]-16-(carboxymethyl)-7,13-bis[(1R)-1-hydroxyethyl]-10-methyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]amino]-3-methylbutanoyl]amino]-3-hydroxybutanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]acetyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxypropanoyl]amino]acetyl]amino]acetyl]amino]-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]hexanoyl]amino]-4-oxobutanoyl]amino]-4-oxobutanoyl]amino]-3-phenylpropanoyl]amino]-3-methylbutanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxybutanoyl]amino]-4-oxobutanoyl]amino]-3-methylbutanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]amino]propanoyl]amino]-3-phenylpropanoic acid
현지명: 칼시토닌유전자관련펩타이드
영어명: Calcitonin Gene-Related Peptide
분자량: 0

이름 및 동의어

83652-28-2JHB2QIZ69ZRefChem:388852Gene-Related Peptide, CalcitoninCalcitonin Gene Related Peptide ICalcitonin gene-related peptide 1DTXSID401064726Calcitonin Gene Related Peptide IIbeta Calcitonin Gene Related Peptidealpha Calcitonin Gene Related Peptidealpha-Calcitonin Gene-Related PeptideCalcitonin, pro-

이름 더 보기

칼시토닌유전자관련펩타이드Calcitonin gene-related peptide free acid

UNII-JHB2QIZ69ZCalcitonin,pro-CALCA protein, humanCALC1 protein, humanCGRP1 protein, humanUNII-SV1QL0ZSJ9Calcitonin gene-relatedpeptideSCHEMBL29357151

데이터베이스 식별자

CAS: 56645-65-9、83652-28-2
PubChem CID: 56841902

물성

구조 계산 물성

XLogP: -16.3
극성 표면적: 1,670 Å²
수소 결합 공여자 수: 57
수소 결합 수용자 수: 58
회전 가능 결합 수: 112
무거운 원자 수: 265
형식 전하: 0
복잡도: 9,010

물리화학적 성질

물리적 상태: Solid
색상: White to off-white

화학 및 산업

약리 정보

Mechanism of Action · 1건

While current drugs for treating HF and MI have a single mechanism of action, CGRP appears to work on several levels: for example, it (1) increases local blood flow enhancing hemodynamic proficiency; (2) protects heart muscle cells from the damage due to lack of oxygen (ischemia); and, (3) modulates the immune system by boosting anti-inflammatory cytokine expression while suppressing pro-inflammatory cytokines, which reduces the inflammatory response to provide a cardioprotective effect. All these actions are meant to minimize heart muscle damage and subsequent scar tissue formation, while promoting the healing process.

MeSH Pharmacological ClassificationDrugs used to cause dilation of the blood vessels.

공급사8 곳

Aladdin Scientific[email protected]

杭州思诺达医药科技有限责任公司0571-87213919 17306812703 · [email protected]

LEON (NANJING) BIOTECHNOLOGY CO., LTD.15051830413 · [email protected]

南京莱昂生物科技有限公司025-84523390 -127; 17705183659 · [email protected]

南京肽业生物科技有限公司025-58361106-805 15951641583 · [email protected]

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