기본 정보
- CAS
915019-08-8- 표준 SMILES
CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@@H](N)CCC(=O)O)[C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)O- InChIKey
WZJRQXZSYQYFJV-QAXVQDKQSA-N- 분자식
- C85H146N26O21
- 평균 분자량
- 1,868.2 g/mol
- 단동위원소 질량
- 1,867.11558577
개요
Tertomotide is under investigation in clinical trial NCT01223209 (A Study, Combination, Immunologic Study of LTX-315 as adjunct to tertomotide in Patients Following Curative Surgery for Carcinoma). It is a peptide vaccine that activates the immune system so that it recognizes and kills cancer cells. It is being developed by Pharmexa A/S.
이름 및 식별자
- 우선 이름
- Tertomotide
- IUPAC
- (2S)-6-amino-2-[[(2S)-1-[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-carboxybutanoyl]amino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]propanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-phenylpropanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbonyl]amino]hexanoic acid
- 영어명
- Tertomotide
- 분자식
- C85H146N26O21
- 분자량
- 1868.23
이름 및 동의어
TERTOMOTIDETertomotide [INN]GV-100155R7RG342O915019-08-8GV 1001tertomotidumTertomotidaPrimoVaxRefChem:896624TERTOMOTIDE [WHO-DD]GV1001
이름 더 보기
L-Lysine, L-α-glutamyl-L-alanyl-L-arginyl-L-prolyl-L-alanyl-L-leucyl-L-leucyl-L-threonyl-L-seryl-L-arginyl-L-leucyl-L-arginyl-L-phenylalanyl-L-isoleucyl-L-prolyl-
HUMAN TELOMERASE REVERSE TRANSCRIPTASE PEPTIDE (AMINO ACID 611-626)UNII-55R7RG342OSCHEMBL29357887GLXC-21865
데이터베이스 식별자
- CAS
915019-08-8- PubChem CID
- 56843375
- ChEMBL
CHEMBL2108308
물성
구조 계산 물성
- XLogP
- -7.6
- 극성 표면적
- 779 Ų
- 수소 결합 공여자 수
- 25
- 수소 결합 수용자 수
- 26
- 회전 가능 결합 수
- 60
- 무거운 원자 수
- 132
- 형식 전하
- 0
- 복잡도
- 3,910
물리화학적 성질
- 밀도
- 1.427 · 1.427±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
- 산도 계수 (pKa)
- 3.605 · 3.605±0.21(predicted)
화학 및 산업
약리 정보
PharmacodynamicsTertomotide is a peptide vaccine that activates the immune system so that it recognises and kills cancer cells.
Mechanism of ActionTertomotide targets an enzyme called telomerase. Telomerase is seldom found in normal cell types but is overexpressed in most cancer cells.
공급사8 곳
太原百利恒康生物技术有限公司19135651983 · [email protected]
LEON (NANJING) BIOTECHNOLOGY CO., LTD.15051830413 · [email protected]
合肥赛曼诺生物科技有限公司0551-65326643 18156095617 · [email protected]
合肥赛曼诺生物科技有限公司0551-65326643 18156095617 · [email protected]
南京莱昂生物科技有限公司025-84523390 -127; 17705183659 · [email protected]
南京肽业生物科技有限公司025-58361106-805 15951641583 · [email protected]
南京美韬医药科技有限公司[email protected] · [email protected]
成都菁临生物科技有限公司17711399154 · [email protected]
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