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기본 정보
- CAS
1160514-60-2- 표준 SMILES
CCOC(=O)c1cnn(-c2ccc(NC(=O)C(Cl)=C(Cl)Cl)cc2)c1C(F)(F)F- InChIKey
RZHGONNSASQOAY-UHFFFAOYSA-N- 분자식
- C16H11Cl3F3N3O3
- 평균 분자량
- 456.635 g/mol
- 단동위원소 질량
- 454.98180891
이름 및 식별자
- 우선 이름
- Ethyl 1-{4-[(2,3,3-trichloroacryloyl)amino]phenyl}-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate
- IUPAC
- Ethyl 1-{4-[(2,3,3-trichloroprop-2-enoyl)amino]phenyl}-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate
- 영어명
- 1-[4-[(2,3,3-Trichloro-1-oxo-2-propen-1-yl)amino]phenyl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylicacid
- 분자식
- C16H11Cl3F3N3O3
- 분자량
- 456.63
이름 및 동의어
Pyr3Pyr3,Pyr-3Pyr3, 10 mM in DMSOPyr3, TRPC3 channel blockerTRPC3 Channel Inhibitor, Pyr3TRPC3 Channel Inhibitor, Pyr3 - CAS 1160514-60-2 - CalbiochemEthyl 1-(4-(2,3,3-trichloroacrylamido)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylateEthyl-1-(4-(2,3,3-trichloroacrylamide)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate1-[4-(2,3,3-Trichloro-acryloylamino)-phenyl]-5-trifluoromethyl-1H-pyrazole-4-carboxylic acid ethyl ester1-[4-[(2,3,3-Trichloro-1-oxo-2-propen-1-yl)amino]phenyl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylicacid
데이터베이스 식별자
- CAS
1160514-60-2- PubChem CID
- 56964346
- DTXSID
DTXSID60719181- ChEMBL
CHEMBL4177187- Nikkaji
- J2.713.185I
물성
물리화학적 성질
- 녹는점
- 151 · 151-153 °C(Solv: toluene (108-88-3))
- 끓는 점
- 534 · 534.0±50.0 °C(Predicted)
- 밀도
- 1.54 · 1.54±0.1 g/cm3(Predicted)
- 저장 조건
- -20 °C · Store at -20°C
- 용해도
- DMSO에 용해됩니다(최대 40mg/ml).
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- 9.97 · 9.97±0.70(Predicted)
- 색상
- 흰색에서 베이지색
- 안정성
- 2 · 제공된 대로 구매일로부터 2년 동안 안정적입니다. DMSO 용액은 -20°C에서 최대 3개월 동안 보관할 수 있습니다.
- InChI
- 1S/C16H11Cl3F3N3O3/c1-2-28-15(27)10-7-23-25(12(10)16(20,21)22)9-5-3-8(4-6-9)24-14(26)11(17)13(18)19/h3-7H,2H2,1H3,(H,24,26)
- InChIKey
- RZHGONNSASQOAY-UHFFFAOYSA-N
- SMILES
- FC(F)(F)c1[n](ncc1C(=O)OCC)c2ccc(cc2)NC(=O)C(=C(Cl)Cl)Cl
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
안전 데이터
- wgk
- WGK 2
- 스토리지 클래스
- 11 - Combustible Solids
화학 및 산업
응용 분야
용도Pyr3 is a pyrazole derivative that is used to discriminate between (transient receptor potential cation) TRPC4 mediated receptor operated calcium entry and STIM1/Ora1 mediated store operated calcium entry pathway in human embryonic kidney and rat mast cells.
일반 설명A cell-permeable pyrazole that acts as an equally potent blocker of Stim1 and Orai1-coupled CRAC (Ca2+ release-activated Ca2+) channel-mediated SOCE (store-operated Ca2+ entry) in RBL-2H3 cells (IC50 = 540 nM by Fura-2; peak current density pA/pF = -1.45 and -7.50, respectively, with or without 3 μM BTP2/Pyr3 by whole cell clamp) and the transient receptor potential cation channel TRPC3-mediated ROCE (receptor-operated Ca2+ entry) in TRPC3-expressing HEK293 cells (IC50 = 540 nM; by Fura-2; pA/pF = -2.27 and -18.50, respectively, with or without 3 μM BTP2/Pyr3). Pyr3 is also demonstrated to alleviate pressure overload-induced cardiac hypertrophy following TAC (transverse aortic constriction) operation in mice (0.1 mg/kg/day via i.p. osmotic pump) in vivo. A great complement to Pyr 2 (Cat. No. 203890), Pyr6, and Pyr10 in Ca2+ signaling studies.
공급사30 곳
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
上海微佳禾生物科技有限公司17502176150; 17502176150 · [email protected]
武汉易泰科技有限公司上海分公司18930552037 · [email protected]
江苏艾康生物医药研发有限公司025-5885952 15955137747 · [email protected]
烟台盛凯伦生物制品有限公司13356901049 · [email protected]
MedBio脉铂医药021-69568360 18916172912 · [email protected]
銳迪國際科技有限公司18024082417 · [email protected]
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