하이이드록시프로게스테론카프로에이트

개요히드 록시 프로게스테론 카프로 에이트 분말 메드 록시 프로게스테론 아세테이트 및 메 게스트 롤 아세테이트와 유사한 합성 스테로이드 호르몬이다. 그것은 caproic acid (hexanoic acid)로부터 형성된 17α-hydroxyprogesterone의 에스테르 유도체이다. Hydroxyprogesterone caproate는 이전에 MAKENA라는 브랜드로 시판되었습니다.

개요Hydroxyprogesterone caproate is a synthetic steroid hormone that is similar to medroxyprogesterone acetate and megestrol acetate. It is an ester derivative of 17α-hydroxyprogesterone formed from caproic acid (hexanoic acid). Hydroxyprogesterone caproate was previously marketed under the trade name Delalutin by Squibb, which was approved by the U.S. Food and Drug Administration (FDA) in 1956 and withdrawn from marketing in 1999. The U.S. FDA approved Makena from KV Pharmaceutical (previously named as Gestiva) on February 4, 2011 for prevention of preterm delivery in women with a history of preterm delivery, sparking a pricing controversy.

용도Hydroxyprogesterone caproate is a synthetic progestin used for the prevention of spontaneous preterm births in singleton pregnancies in women who have previously had a spontaneous preterm birth.

일반 설명Hydroxyprogesteronecaproate, 17-hydroxypregn-4-ene-3,20-dionehexanoate, is much more active and longer acting than progesterone, probably because the 17αester hinders reduction to the 20-ol. In contrast, hydroxyprogesteroneitself lacks progestational activity. Thecaproate ester is given only intramuscularly. The estergreatly increases oil solubility, allowing it to be slowly releasedfrom depot preparations. Although only currently available throughcompounding pharmacies, a new formulation (Gestiva) wasdeemed approvable by the FDA in late 2006 for the preventionof preterm labor, pending further studies.