염산구아니딘
아미노메탄아미딘하이드로클로라이드 · 염산구아니딘 · 구아니딘에이치씨엘 · 구아니딘 하이드로클로라이드 · GUANIDINE HCL · GUANIDINIUM CHLORIDE · GACl · GdmCl
식별자 및 물리적 특성
| CAS No. | 50-01-1 |
|---|---|
| 분자식 | CH5N3.ClH |
| 평균 분자량 | 95.53 g/mol |
| 단동위원소 질량 | 95.02502487 g/mol |
| SMILES | Cl.N=C(N)N |
| InChIKey | PJJJBBJSCAKJQF-UHFFFAOYSA-N |
| PubChem CID | 5742 |
| ChEMBL | CHEMBL1200728 |
| EC No. | 200-002-3 |
| DTXSID | DTXSID7058757 |
| 현지명 | 염산구아니딘 |
화학 및 물리적 성질
| 극성 표면적 | 75.9 |
|---|---|
| 수소 결합 공여자 수 | 4 |
| 수소 결합 수용자 수 | 1 |
| 회전 가능 결합 수 | 0 |
| 무거운 원자 수 | 5 |
| 형식 전하 | 0 |
| 복잡도 | 26.3 |
| 화장품 | Buffering |
| LogP(분배 계수) | -1.7 |
| 밀도 | 1.3 g/cm³1.18 g/mL at 25 °C(lit.) |
| 용해도 | Solubility in water, g/100ml at 20 °C: 215H2O: 6 M, 투명, 무색 |
| Human Drugs | FDA approved drugs -> Active ingredient |
| 녹는점 | 178-185 °C183 °C180-185 °C(lit.) |
| Physical Description | Large CrystalsDry PowderLiquidHYGROSCOPIC CRYSTALLINE POWDER. |
| 굴절률 | n20/D 1.465 |
| 저장 조건 | room temp |
| 물리적 상태 | 크리스탈 |
| pKa(산도 계수) | 13.5(Temp: 27 °CSolvent: Water) |
| 색상 | 흰색에서 약간 노란색 |
| pH | 4.5-5.5 (100g/l, H2O, 20℃) |
| 냄새 | 냄새 없는 |
| 생물학적 소스 | synthetic (organic) |
| 용해도 | 2280g/L(20℃) |
| Merck | 14,4562 |
| BRN | 3591990 |
| 안정성 | 안정적인. 흡습성. 강한 산화제와 호환되지 않습니다. |
| 화장품 원료 기능 | 버퍼링 |
| InChI | 1S/CH5N3.ClH/c2-1(3)4/h(H5,2,3,4)1H |
| InChIKey | PJJJBBJSCAKJQF-UHFFFAOYSA-N |
| SMILES | Cl[H].NC(N)=N |
| EPA | Guanidine monohydrochloride (50-01-1) |
| Absorption | ≤0.10 at 260nm in H2O at 6M |
화학적 성질
Guanidine hydrochloride, a strong organic base, appears as white crystal powder or yellowish lumps that are almost insoluble in acetone, benzene, and ether. In physiological pH, it exists primarily as guanidium ions. It is a natural byproduct of protein metabolism found in urine and is commonly used in protein denaturation in laboratory research.
안전 및 규제
| GHS 분류 | WarningH302: Harmful if swallowed [Warning Acute toxicity, oral]P264, P264+P265, P270, P280, P301+P317, P302+P352, P305+P351+P338, P321, P330, P332+P317, P337+P317, P362+P364, and P501 (click each P-code to see the statement)This chemical does not meet GHS hazard criteria for 9.2% (37 of 404) of reports.H302 (90.8%): Harmful if swallowed [Warning Acute toxicity, oral] |
|---|---|
| 규제 정보 | Chemical: Guanidine, monohydrochlorideGuanidine, hydrochloride (1:1) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Guanidine, hydrochloride (1:1) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 12-05-2021 https://echa.europa.eu/registration-dossier/-/registered-dossier/13899Guanidinium chloride: Does not have an individual approval but may be used under an appropriate group standard |
| 화재 위험 | Combustible. |
| EC 분류 | Symbol: XnR: 22-36/38S: (2)-22 |
| Chemical Dangers | On combustion, forms toxic and corrosive fumes including hydrogen chloride and nitrogen oxides. The solution in water is a weak acid. |
| Hazard Classes and Categories | Acute Tox. 4 (90.8%)Acute toxicity - category 4Acute toxicity (Oral) - Category 4Acute Tox. 4 * |
| 소화 | Use foam, powder. |
| 응급 조치 | Fresh air, rest.Rinse skin with plenty of water or shower.First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.Rinse mouth. Give one or two glasses of water to drink. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). |
| 안전 보관 | Well closed. Dry. |
| 누출 처리 | Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Wash away remainder with plenty of water. Personal protection: P2 filter respirator for harmful particles. |
용도
개요
구아니딘(guanidine)은 구조식이 HN=C(NH2)2의 구조를 가진 유기 화합물이다. 강한 염기성을 가진 결정성의 고체로, 구아닌을 분해해 얻을 수있다. 또한 단백질의 대사에 의해 생성되고 소변 중에서도 검출된다.
용도
플라스틱이나 폭약의 원료로 사용된다. 또한 수소결합 을 만들기 쉬운 성질때문에 염산이나 소금에 의해 단백질이 변성되는 것을 방지하는데 사용된다 (GdmCl로 알려져 있다). 화석연료의 대체연료로 이용하는 연구도 진행되고있다. 유도체는 유기합성을 통해 강한 염기로 사용된다.
용도
Guanidine hydrochloride is used for purification of proteins and nucleic acids. It can be used as a medicine, organic synthesis intermediate and is used in dyes. It acts as an intermediate in the preparation of sulfadiazine, which is an important raw material for sulfamethyldiazine, sulfamethazine and folic acid. It is utilized in the synthesis of 2-amino-pyrimidine, 2- amino -6- methyl-pyrimidine and 2-amino -4,6 - dimethyl-pyrimidine. Also used in RNA isolation to dissociate nucleoproteins and inhibit RNase.
일반 설명
Guanidine hydrochloride (GdnHCl) is a well-known protein and enzyme denaturant. It is a small molecule and hydroscopic in nature. It is used to synthesis medicine, pesticide, dye and other organic compound, is the important material to make sulfanilamide medicine and folacin, and can be used as anti-static agent of compound fibre.
제조 및 합성 방법
제조 방법
The process for preparing guanidine hydrochloride is as follows:Step 1: Fritting - Combine dicyandiamide and ammonium chloride in a reactor with a 1:1.27 weight ratio and carry out a frit reaction at 170-230°C to obtain crude guanidine hydrochloride.Step 2: Dissolving - Dissolve the crude guanidine hydrochloride in water at a 1:1 ratio at normal temperature. Then, add ammonium salt alkaloid in an amount determined by the ammonium salt content in the crude guanidine hydrochloride.Step 3: Filtering - Remove raw materials and reaction by-products with filtration.Step 4: Dehydrating - Dehydrate the filtered ground mother liquor at a high temperature.Step 5: Crystallizing - Cool the supersaturated solution, concentrate, and crystallize to obtain high-purity guanidine hydrochloride.Step 6: Repeat steps 2-5 and add dicyandiamide in the reactor with the guanidine hydrochloride to carry out frit reaction at 170-230°C for 3-4 hours to obtain even higher purity guanidine hydrochloride. This step can be repeated several times if needed.Step 7: To obtain higher purity guanidine hydrochloride, subject the guanidine hydrochloride obtained in step 5 to steps 2-5 again, with the water ratio in step 2 adjusted to 1.5:1. This step can be repeated numerous times as required.