기본 정보
- CAS
4039-32-1- 표준 SMILES
C[Si](C)(C)N[Si](C)(C)C.[Li]- InChIKey
QQIRAVWVGBTHMJ-UHFFFAOYSA-N- 분자식
- C6H19LiNSi2
- 평균 분자량
- 168.4 g/mol
개요
structure in first source
이름 및 식별자
- 우선 이름
- Lithium bis(trimethylsilyl)amide
- 영어명
- Lithium bis(trimethylsilyl)amide
- 분자식
- C6H18LiNSi2
- 분자량
- 167.33
이름 및 동의어
Bis(trimethylsilyl)amidolithiumLithiumbis(trimethylsilyl)amineBis(trimethylsilyl)amido lithiumLi bis(TMS)ARefChem:924827(LiN(SiMe3)2)223-725-64039-32-1Disilazane, 1,1,1,3,3,3-hexamethyl-, lithium saltLithium bis(trimethylsilyl)amideLithium, (bis(trimethylsilyl)amino)-Lithiumbis(trimethylsilyl)amide
이름 더 보기
LIHMDSLHMDSLiHDMSLITHIUM HEXAMETHYLDISILAZANELithium 1,1,1,3,3,3-hexamethyldisilazideLITHIUM HEXAMETHYLDISILAZIDELithium bis(trimethylsilyl)amide solutionLiHMDS（1M）HMDS LiLiHMDS 1M in THF
lithium bis(trimethylsilyl)aminelithium HMDSlithiumhexamethyldisilazanelithium hexamethydisilazanelithium hexamethyidisilazanelithium hexamethyl disilazanelithium hexamethyl-disilazanelithium(hexamethyldisilazane)
데이터베이스 식별자
- CAS
4039-32-1- PubChem CID
- 57426343
- EC Number
- 223-725-6
물성
구조 계산 물성
- 극성 표면적
- 12 Ų
- 수소 결합 공여자 수
- 1
- 수소 결합 수용자 수
- 1
- 회전 가능 결합 수
- 2
- 무거운 원자 수
- 10
- 형식 전하
- 0
- 복잡도
- 76.2
실험 및 물리화학적 성질
Chemical ClassesMetals -> Metalloid Compounds (Silicon)
Physical Description
Wet Solid
White powder; [Alfa Aesar MSDS]
물리화학적 성질
- 녹는점
- 73 °C · 73°C
- 끓는 점
- 55 · 55-56 °C
- 밀도
- 0.86 g/mL · 0.860 g/mL at 25 °C (lit.)
- 굴절률
- 20 · n20/D 1.425(lit.)
- 인화점
- 48 °F · 48 °F
- 저장 조건
- 30 °C · Store below +30°C.
- 용해도
- 가수 분해
- 물리적 상태
- 가루
- 색상
- 하얀색
- Specific Gravity
- 0.716 · 0.716
- 수용성
- 가수 분해
- BRN
- 3567910 · 3567910
- 주요 응용
- 배터리 전구체촉매재료 합성 전구체
- InChI
- 1S/C6H18NSi2.Li/c1-8(2,3)7-9(4,5)6;/h1-6H3;/q-1;+1
- InChIKey
- YNESATAKKCNGOF-UHFFFAOYSA-N
- SMILES
- [Li]N([Si](C)(C)C)[Si](C)(C)C
- EPA
- 1 · Silanamine, 1,1,1-trimethyl-N-(trimethylsilyl)-, lithium salt (4039-32-1)
화학적 성질
light yellow to yellow crystalline powder
안전 및 규제
GHS 분류
GHS Classification
Danger
H228 (43.9%): Flammable solid [Danger Flammable solids]
P210, P240, P241, P260, P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P330, P362+P364, P363, P370+P378, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 198 reports by companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
유해성 정보
Regulatory Information
Silanamine, 1,1,1-trimethyl-N-(trimethylsilyl)-, lithium salt (1:1) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Silanamine, 1,1,1-trimethyl-N-(trimethylsilyl)-, lithium salt (1:1) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)
Status: Active Update: 19-10-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/13861
1,1,1,3,3,3-Hexamethyldisilazane lithium salt: Does not have an individual approval but may be used under an appropriate group standard
Hazards SummaryReacts violently with water evolving extremely flammable gases; Causes burns; [Alfa Aesar MSDS] See Silanamine, 1,1,1-trimethyl-N-(trimethylsilyl)-, hydrolysis products with silica. See Hexamethyldisilazane. See Lithium.
Hazard Classes and CategoriesFlam. Sol. 2 (43.9%)
독성 정보
Adverse EffectsDermatotoxin - Skin burns.
안전 데이터
- wgk
- 3
- tsca
- TSCA listed
- ridadr
- UN 2925 4.1/PG 2
- HS 번호
- 29319090
- risk_code
- 11-34-48/20-63-65-67-51/53-35-20-62-14-40-37-19
- hazard_code
- F,C,N
- safety_code
- 9-16-26-29-33-36/37/39-45-61-62-57-43
- 포장분류
- II
- 위험 등급
- 4.3
- F 고인화성물질
- 10-23
- Hazard Classifications
- Eye Dam. 1Flam. Sol. 1Self-heat. 1Skin Corr. 1B
- 스토리지 클래스
- 4.2 - Pyrophoric and self-heating hazardous materials
화학 및 산업
용도 및 제조
UsesUsed as an intermediate; [ExPub: ECHA REACH Registrations]
U.S. Production2023: <50,000 lb
Industry UsesIntermediate
General Manufacturing Information
Pharmaceutical and Medicine Manufacturing
Silanamine, 1,1,1-trimethyl-N-(trimethylsilyl)-, lithium salt (1:1): ACTIVE
응용 분야
용도Lithium bis(trimethylsilyl)amide is used as nonnucleophilic base to generate kinetic ketone and ester enolates. It is considerably more selective than LDA and undesired reductions (e.g., of nonenolizable ketones observed in the case of LDA) can be avoided by using LHMDS.
일반 설명This product, 0.5 M in 2-methyltetrahydrofuran aligns with Safer Solvents and Auxiliaries, Use of Renewable Feedstocks and Inherently Safer Chemistry for Accident Prevention.
제조 방법
It is conveniently prepared by the reaction of hexamethyldisilazane with n-butyllithium in hexane. For most uses the hexane is then evaporated and replaced with THF.
상·하류 제품 정보
상류 원료
하류 제품
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