미토미신 C

미토미신C · MITOMYCIN · MMC · MITOMYCIN A · AMETYCIN · MitoMyci · MITOCIN C · MUTAMYCIN

식별자 및 물리적 특성

CAS No.	50-07-7
분자식	C15H18N4O5
평균 분자량	334.33 g/mol
단동위원소 질량	334.12771969 g/mol
SMILES	CO[C@@]12[C@H](COC(N)=O)C3=C(C(=O)C(C)=C(N)C3=O)N1C[C@@H]1N[C@@H]12
InChIKey	NWIBSHFKIJFRCO-WUDYKRTCSA-N
PubChem CID	5746
ChEMBL	CHEMBL105
ChEBI	CHEBI:27504
EC No.	200-008-6
DTXSID	DTXSID2020898
현지명	미토미신 C

화학 및 물리적 성질

XLogP	-0.4
극성 표면적	147
수소 결합 공여자 수	3
수소 결합 수용자 수	8
회전 가능 결합 수	4
무거운 원자 수	24
형식 전하	0
복잡도	757
LogP(분배 계수)	-0.4logP = -0.40-1.6
Color/Form	BLUE-VIOLET CRYSTALS
용해도	Soluble (NTP, 1992)Soluble (8430 mg/L)SOL IN WATER, METHANOL, BUTYL ACETATE, ACETONE, AND CYCLOHEXANONESLIGHTLY SOL IN BENZENE, ETHER, AND CARBON TETRACHLORIDEPRACTICALLY INSOL IN PETROLEUM ETHER.Freely soluble in organic solvents1.01e+01 g/LH2O: 4 mL/바이알 스톡 솔루션은 필터 멸균하고 어두운 곳에서 2~8°C로 보관해야 합니다. 투명하거나 약간 흐릿하며 파란색에서 보라색까지입니다.
끓는 점	534471.14°C (rough estimate)
녹는점	Above 680 °F (EPA, 1998)>360 °CABOVE 360 °C> 360 °C
헨리 상수	LogP = -0.38Henry's Law constant = 2.5X10-10 atm-cu m/mol
Physical Description	Mitomycin c appears as blue-violet crystals. Used as an anti-tumor antibiotic complex. (EPA, 1998)Water-soluble crystals that are blue-violet[CAMEO]Solid
Stability/Shelf Life	Commercially available mitomycin powder is stable for at least 4 years at room temperature.
Dissociation Constants	10.9
Collision Cross Section	169.5 Å² [M+H]+ [CCS Type: TWMethod: calibrated with polyalanine and drug standards]
밀도	1.2238 (rough estimate)
굴절률	1.6800 (estimate)
저장 조건	2-8°C
물리적 상태	가루
pKa(산도 계수)	pKa 2.8(H2O,t =25,I=0.1) (Uncertain)
색상	청회색
pH	pH (0.5 g/l, 25℃ : )5.0～7.0
용해도	녹는
Merck	14,6215
BRN	7231816
안정성	안정적인. 강산, 강염기, 강산화제와 호환되지 않습니다.
InChI	1S/C15H18N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23-2)13-7(18-13)3-19(15)10(8)11(5)20/h6-7,13,18H,3-4,16H2,1-2H3,(H2,17,22)/t6-,7+,13+,15-/m1/s1
InChIKey	NWIBSHFKIJFRCO-WUDYKRTCSA-N
EPA	Mitomycin C (50-07-7)

화학적 성질

Blue-violet crystals or crystalline powder.

안전 및 규제

GHS 분류	DangerH300 (75.4%): Fatal if swallowed [Danger Acute toxicity, oral]H301 (21.7%): Toxic if swallowed [Danger Acute toxicity, oral]H351 (94.2%): Suspected of causing cancer [Warning Carcinogenicity]P203, P264, P270, P280, P301+P316, P318, P321, P330, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 69 reports by companies from 12 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.
규제 정보	Hazard Traits - CarcinogenicityAuthoritative List - IARC Carcinogens - 2BProp 65Report - regardless of intended function of ingredient in the productS - indicates a substance that is identified in a final Significant New Use Rule.Azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione, 6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methyl-, (1aS,8S,8aR,8bS)-: Does not have an individual approval but may be used under an appropriate group standardThe New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)
기타 안전 정보	IMAP assessments - Azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione, 6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methyl-, [1aS-(1a.alpha.,8.beta.,8a.alpha.,8b.alpha.)]-: Environment tier I assessmentIMAP assessments - Azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione, 6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methyl-, [1aS-(1a.alpha.,8.beta.,8a.alpha.,8b.alpha.)]-: Human health tier I assessment
운송 라벨(DOT)	Poison
화재 위험	Flash point data for this chemical are not availablehowever, it is probably combustible. (NTP, 1992)
건강 유해성

용도

개요

Mitomycin C is naturally produced by Streptomyces caespitosus, an Actinobacteria found in soil. Mitomycin C has antibiotic and antitumor activities and has been studied extensively since the 1950s. A unique feature of this drug is strong bioreductive alkylation under hypoxic conditions. Oxygen-poor cells internal to solid tumors provide an environment in which this drug is highly activated. As an antitumor agent, it has shown efficacy in a wide variety of cancers, including gastric cancer, pancreatic cancer, breast cancer, non-small-cell lung cancer, cervical cancer, prostate cancer, and bladder cancer. The sideeffect profile is large, which prohibits its widespread use. Mitomycin C is antibacterial to gram-positive, gram-negative, and acid-fast bacilli.

용도

Mitomycin C is the most studied of a family of highly distinctive blue/purple metabolites produced by several Streptomyces species. Mitomyin C exhibits potent antibacterial and antitumour activity and inhibits DNA synthesis by intercalation, blocking nuclear division with the induction of apoptosis in cancer cells.

일반 설명

Blue-violet crystals. Used as an anti-tumor antibiotic complex.