기본 정보
- CAS
51-42-3- 표준 SMILES
CNC[C@H](O)c1ccc(O)c(O)c1.O=C(O)[C@H](O)[C@@H](O)C(=O)O- InChIKey
YLXIPWWIOISBDD-NDAAPVSOSA-N- 분자식
- C9H13NO3.C4H6O6
- 평균 분자량
- 333.29 g/mol
- 단동위원소 질량
- 333.10598119
개요
Epinephrine Bitartrate is the bitartrate salt form of epinephrine, a direct-acting sympathomimetic amine with bronchodilator and vasoconstricting activity.
이름 및 식별자
- 우선 이름
- Epinephrine Bitartrate
- IUPAC
- (2R,3R)-2,3-dihydroxybutanedioic acid;4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol
- 영어명
- Epinephrine bitartrate
- 분자식
- C13H19NO9
- 분자량
- 333.29
이름 및 동의어
Epinephrine bitartrate51-42-3Adrenaline bitartrateBronitinAdrenaline acid tartrateBronitin MistEPINEPHRINE TARTRATEEpinephrine d-bitartrateDTXSID3049415(-)-Epinephrine bitartrate(-)-Epinephrine (+)-bitartrateAdrenaline bitartate
이름 더 보기
L-ADRENALINE BITARTRATEAdrenaliniumEpinephnne bitartrateL-EPINEPHRINE BITARTRATEEPINEPHRINE ACID TARTRATEAdrenaline tartrate with impurity A CRSD02149ADRENAL, RAT
30Q7KI53AKAdrenaline (as tartrate)Epinephrine hydrogen tartrateL-epinephrine hydrogen tartrateDTXCID2029375Adrenalin tartrateNSC-756755Epinephrini hydrogenotartras
데이터베이스 식별자
- CAS
51-42-3- PubChem CID
- 5815
- DTXSID
DTXSID3049415- ChEMBL
CHEMBL1200818、CHEMBL1256958
물성
구조 계산 물성
- 극성 표면적
- 188 Ų
- 수소 결합 공여자 수
- 8
- 수소 결합 수용자 수
- 10
- 회전 가능 결합 수
- 6
- 무거운 원자 수
- 23
- 형식 전하
- 0
- 복잡도
- 288
실험 및 물리화학적 성질
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Animal DrugsPharmaceuticals -> UK Veterinary Medicines Directorate List
물리화학적 성질
- 녹는점
- 155 °C · ~155 °C (dec.)
- 굴절률
- -16.5 ° · -16.5 ° (C=2, H2O)
- 저장 조건
- 2 · 2-8°C
- 용해도
- 2 O: · H2O: 용해성
- 물리적 상태
- 고체
- 색상
- 하얀색
- Merck
- 13 · 13,3650
- 안정성
- 안정적인. 염기, 산화제, 철, 철염, 구리, 구리 합금과 호환되지 않습니다.
- 주요 응용
- 의약품(소분자)
- InChI
- InChI=1S/C9H13NO3.C4H6O6/c1-10-5-9(13)6-2-3-7(11)8(12)4-6;5-1(3(7)8)2(6)4(9)10/h2-4,9-13H,5H2,1H3;1-2,5-6H,(H,7,8)(H,9,10)
- InChIKey
- YLXIPWWIOISBDD-NDAAPVSOSA-N
- SMILES
- OC1=C(O)C=CC(C(CNC)O)=C1.OC(C(C(C(O)=O)O)O)=O
화학적 성질
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
Danger
H300 (99.1%): Fatal if swallowed [Danger Acute toxicity, oral]
P261, P264, P264+P265, P270, P271, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 106 reports by companies from 13 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
유해성 정보
Regulatory Information
Chemical: 1,2-Benzenediol, 4-[1-hydroxy-2-(methylamino)ethyl]-, (R)-,[R-(R*,R*)]-2,3-dihydroxybutanedioate (1:1) (salt)
Epinephrine bitartrate: HSNO Approval: HSR003812 Approved with controls
Other Safety InformationIMAP assessments - 1,2-Benzenediol, 4-[1-hydroxy-2-(methylamino)ethyl]-, (R)-,[R-(R*,R*)]-2,3-dihydroxybutanedioate (1:1) (salt): Environment tier I assessment
Hazard Classes and CategoriesAcute Tox. 1 (99.1%)
안전 데이터
- wgk
- 3
- rtecs
- DO3500000
- ridadr
- UN 2811 6.1/PG 1
- HS 번호
- 29379000
- risk_code
- 28-36/37/38
- hazard_code
- T+
- safety_code
- 26-28-36/37-45
- 포장분류
- III
- 위험 등급
- 6.1(b)
- F 고인화성물질
- 8-10-23
- Hazard Classifications
화학 및 산업
약리 정보
MeSH Pharmacological Classification
Drugs that selectively bind to and activate alpha adrenergic receptors.
Drugs that selectively bind to and activate beta-adrenergic receptors.
Agents that cause an increase in the expansion of a bronchus or bronchial tubes.
Agents that dilate the pupil. They may be either sympathomimetics or parasympatholytics.
Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters.
Drugs used to cause constriction of the blood vessels.
응용 분야
개요Epinephrine bitartrate is the bitartrate salt form of epinephrine, a direct-acting sympathomimetic amine with bronchodilator and vasoconstricting activity. Epinephrine bitartrate acts on both alpha and beta-adrenergic receptors. By stimulating alpha-adrenergic receptors locally, this agent causes vasoconstriction and reduces vascular blood flow. Administered in the conjunctiva, epinephrine bitartrate induces vasoconstriction and decreases the production of aqueous humor mediated through alpha-adrenergic receptors. This agent relaxes bronchial smooth muscle through its beta-stimulating actions and causes bronchodilation.
용도Epinephrine bitartrate is an adrenergic agonist, bronchodilator, antiglaucoma agent.
일반 설명α,β-Adrenergic receptor agonist. Has positive chronotropic and inotropic effects on heart muscle. Activates adenylate cyclase to generate cAMP from ATP.
공급사100 곳
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
合肥翰刚医药科技有限公司+8618062405514 · [email protected]
Baoji Guokang Healthchem co.,ltd
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