Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HCID 5820생성일: 2026년 10월 27일
디베나민
디베나민 · N,N-Dibenzyl-2-chloroethan-1-amine · SKF 199 · Dibenamine · (2-Chloroethyl)dibenzylamine · N,N-dibenzyl-2-chloroethanamine · bis(benzyl)-(2-chloroethyl)amine · 2-chloro-N,N-bis(phenylmethyl)ethanamine
https://huagongshe.com/ko/chemical/5820
식별자 및 물리적 특성
| CAS No. | 51-50-3 |
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| 분자식 | C16H18ClN |
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| 평균 분자량 | 259.77 g/mol |
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| 단동위원소 질량 | 259.11277726 g/mol |
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| SMILES | ClCCN(Cc1ccccc1)Cc1ccccc1 |
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| InChIKey | GSLWSSUWNCJILM-UHFFFAOYSA-N |
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| PubChem CID | 5820 |
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| ChEMBL | CHEMBL3305685 |
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| DTXSID | DTXSID20199001 |
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| 현지명 | 디베나민 |
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화학 및 물리적 성질
| XLogP | 3.8 |
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| 극성 표면적 | 3.2 |
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| 수소 결합 공여자 수 | 0 |
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| 수소 결합 수용자 수 | 1 |
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| 회전 가능 결합 수 | 6 |
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| 무거운 원자 수 | 18 |
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| 형식 전하 | 0 |
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| 복잡도 | 187 |
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| Color/Form | OILY LIQUID |
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| Stability/Shelf Life | TURNS YELLOW ON STORAGE & DECOMP ON STANDING TO FORM SOLID POLYMERIC COMPD /CHLOROETHYLAMINES/STABLE IN ACID SOLN BUT RAPIDLY LOSES ACTIVITY IN NEUTRAL OR ALKALINE AQ SOLUTIONS /HYDROCHLORIDE/ |
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| Other Experimental Properties | MP: 192 °C, ALSO GIVEN AS 180-181 °CPRACTICALLY INSOL IN H2O NEAR NEUTRALITYSOLUBLE IN DIL ACID: 2% @ PH 2.1, 1% @ PH 2.4, 0.5% @ PH 2.74SOL IN 95% ALCOHOL, PROPYLENE GLYCOL /HYDROCHLORIDE/COLORLESS CRYSTALLINE SOLID /CHLOROETHYLAMINE HYDROCHLORIDE/ |
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| 녹는점 | 192 °C |
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| 끓는 점 | 407.11°C (rough estimate) |
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| 밀도 | 1.0738 (rough estimate) |
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| 굴절률 | 1.6000 (estimate) |
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| pKa(산도 계수) | 6.50±0.50(Predicted) |
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안전 및 규제
| 상호 작용 | ...ATROPINE APPEARS TO ANTAGONIZE ACTION OF DIBENAMINE OR "DEBLOCK".REDN IN PRESSOR RESPONSE WITHOUT REVERSAL IS USUALLY SEEN WHEN CAPACITY FOR ADRENERGIC VASODILATATION IS LIMITED BY ANY FACTOR, FOR EXAMPLE, SYMPATHOMIMETIC AMINE USED (NOREPINEPHRINE, PHENYLEPHRINE, OR OTHER AGENTS WITH MINIMAL BETA-ADRENERGIC AGONISTIC ACTIVITY) OF PREPN EMPLOYED...FORMATION OF 7% FORMALADHYDE INDUCED SC GRANULOMA WAS GREATLY SUPPRESSED BY EPINEPHRINE & SLIGHTLY BY NOREPINEPHRINE. DIBENAMINE WAS A WEAKER EXPTL GRANULOMA SUPPRESSOR.CENTRAL EFFECTS OF SOME ADRENOLYTICS ON SPONTANEOUS MOTILITY & ON POTENTIATION OF SUBHYPNOTIC DOSES OF SODIUM PENTOBARBITAL WERE STUDIED IN MICE. DIBENAMINE POTENTIATED THE ACTION OF SODIUM PENTOBARBITAL. ALL DRUGS, EXCEPT BRETYLIUM DECR SPONTANEOUS MOTILITY.For more Interactions (Complete) data for DIBENAMINE (9 total), please visit the HSDB record page. |
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| Human Toxicity Excerpts | DIBENAMINE.../STIMULATES/ CNS TO CAUSE NAUSEA, VOMITING, HYPERVENTILATION, MOTOR EXCITABILITY...CONVULSIONS, PARTICULARLY WHEN RELATIVELY LARGE DOSE IS RAPIDLY INJECTED IV. IN MAN, CHARACTERISTIC LOSS OF TIME PERCEPTION MAY OCCUR.LOSS OF VASOMOTOR CONTROL CAN RESULT IN POSTURAL HYPOTENSION & REFLEX TACHYCARDIA IN AMBULATORY PATIENTS, OR A SHARP FALL IN BLOOD PRESSURE IN THOSE WHO ARE HYPOVOLEMIC. /ALPHA-ADRENERGIC BLOCKING AGENTS/OTHER RESULTS OF ALPHA-RECEPTOR BLOCKADE INCL MIOSIS, NASAL STUFFINESS, & INHIBITION OF EJACULATION. /ALPHA-ADRENERGIC BLOCKING AGENTS/ |
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| Non-Human Toxicity Excerpts | ...TACHYCARDIA IN INTACT ANIMALS IS USUALLY EXAGGERATED BECAUSE PRESSOR RESPONSE IS PREVENTED & REFLEX VAGAL STIMULATION IS MINIMIZED. ...DIBENAMINE INDUCE/S/ REFLEX TACHYCARDIA...BOVINE BRAIN SODIUM-POTASSIUM ACTIVATED ATPASE WAS IRREVERSIBLY INHIBITED BY DIBENAMINE & DIBENAMINE ANALOGS WHICH ARE ADRENERGIC ALPHA-BLOCKERS. |
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| 유해 물질 데이터 | 51-50-3(Hazardous Substances Data) |
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