기본 정보
- CAS
51-63-8- 표준 SMILES
C[C@H](N)Cc1ccccc1.C[C@H](N)Cc1ccccc1.O=S(=O)(O)O- InChIKey
PYHRZPFZZDCOPH-QXGOIDDHSA-N- 분자식
- C18H28N2O4S
- 평균 분자량
- 368.5 g/mol
- 단동위원소 질량
- 368.17697855
개요
Dextroamphetamine Sulfate is the salt of the dextro-isomer of amphetamine and sympathomimetic amine with CNS stimulating properties. Dextroamphetamine sulphate acts by facilitating the release of catecholamines, particularly noradrenaline and dopamine, from nerve terminals in the brain and inhibits their uptake. This leads to an increase in motor activity, causes euphoria, mental alertness and excitement and suppresses appetite. This drug causes dependence and may cause an increase in heart rate and blood pressure. It is used in the treatment of narcolepsy and attention deficit hyperactivity disorder.
이름 및 식별자
- 우선 이름
- Dextroamphetamine Sulfate
- IUPAC
- bis((2S)-1-phenylpropan-2-amine);sulfuric acid
이름 및 동의어
Dextroamphetamine sulfateDexampexDextrostatFerndexDextroamphetamine sulphateDexamphetamine sulfateDexamphetamine sulphated-Amphetamine sulphateD-Amphetamine hemisulfate salt(+)-Amphetamine sulphateDexamfetamine sulfateDextroamphetamine Sulfate CII
이름 더 보기
Dextro-Amphetamine SulfateDTXSID2057865JJ768O327Nd-alpha-Methylphenethylamine sulfateNSC-27104Dextro-beta-phenylisopropylamine sulfateDextro-alpha-methylphenethylamine sulfate(S)-alpha-Methylbenzeneethanamine sulfate
데이터베이스 식별자
- CAS
51-63-8- PubChem CID
- 5825
- DTXSID
DTXSID2057865- ChEMBL
CHEMBL3544971- UNII
- JJ768O327N
- EC Number
- 200-111-6
물성
구조 계산 물성
- 극성 표면적
- 135 Ų
- 수소 결합 공여자 수
- 4
- 수소 결합 수용자 수
- 6
- 회전 가능 결합 수
- 4
- 무거운 원자 수
- 25
- 형식 전하
- 0
- 복잡도
- 166
실험 및 물리화학적 성질
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
Danger
H300 (97.9%): Fatal if swallowed [Danger Acute toxicity, oral]
P264, P270, P301+P316, P321, P330, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 48 reports by companies from 5 notifications to the ECHA C&L Inventory.
유해성 정보
Regulatory InformationDextroamphetamine sulphate: Does not have an individual approval but may be used under an appropriate group standard
Other Safety InformationIMAP assessments - Benzeneethanamine, .alpha.-methyl-, (S)-, sulfate (2:1): Environment tier I assessment
Hazard Classes and CategoriesAcute Tox. 2 (97.9%)
독성 정보
Drug Induced Liver Injury
Drug Induced Liver Injury Rank (DILIrank 2.0)
Dextroamphetamine sulfate
vNo-DILI-concern
0
No match
DOI:10.1016/j.drudis.2016.02.015
화학 및 산업
약리 정보
FDA Pharmacological Classification
DEXTROAMPHETAMINE SULFATE
Central Nervous System Stimulant [EPC]; Central Nervous System Stimulation [PE]
MeSH Pharmacological Classification
A loosely defined group of drugs that tend to increase behavioral alertness, agitation, or excitation. They work by a variety of mechanisms, but usually not by direct excitation of neurons. The many drugs that have such actions as side effects to their main therapeutic use are not included here.
Drugs that block the transport of DOPAMINE into axon terminals or into storage vesicles within terminals. Most of the ADRENERGIC UPTAKE INHIBITORS also inhibit dopamine uptake.
관련 반응
1건
화합물 노트
불러오는 중…