기본 정보
- CAS
53-46-3- 표준 SMILES
CC[N+](C)(CC)CCOC(=O)C1c2ccccc2Oc2ccccc21.[Br-]- InChIKey
PQMWYJDJHJQZDE-UHFFFAOYSA-M- 분자식
- C21H26BrNO3
- 평균 분자량
- 420.3 g/mol
- 단동위원소 질량
- 419.10961
개요
Methantheline bromide is a member of xanthenes.
이름 및 식별자
- 우선 이름
- Methantheline Bromide
- IUPAC
- diethyl-methyl-[2-(9H-xanthene-9-carbonyloxy)ethyl]azanium bromide
- 현지명
- 메탄테린브로마이드(200MG)
- 영어명
- METHANTHELINE BROMIDE
- 분자식
- CH3-
- 분자량
- 15.03452
이름 및 동의어
METHANTHELINE BROMIDE53-46-3BanthineVagantinMethanthelinium bromideDixamone bromideDTXSID7023277NSC-32145090519SAPFDTXCID603277Ethanaminium, N,N-diethyl-N-methyl-2-((9H-xanthen-9-ylcarbonyl)oxy)-, bromideRefChem:57334
이름 더 보기
메탄테린브로마이드(200MG)Methanthelinemtb51sc2910ulcineavagalmetaxanvagaminBantosal
200-176-0FrenogastricoGastrosedanResobantinUlcudexterAsabaineBanthinDoladene
데이터베이스 식별자
- CAS
53-46-3- PubChem CID
- 5883
- DTXSID
DTXSID7023277- ChEMBL
CHEMBL1200988- ChEBI
CHEBI:6818- UNII
- 090519SAPF
- EC Number
물성
구조 계산 물성
- 극성 표면적
- 35.5 Ų
- 수소 결합 공여자 수
- 0
- 수소 결합 수용자 수
- 4
- 회전 가능 결합 수
- 7
- 무거운 원자 수
- 26
- 형식 전하
- 0
- 복잡도
- 426
실험 및 물리화학적 성질
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
물리화학적 성질
- 녹는점
- 175 · 175-176°
- 밀도
- 1.338 · 1.3380 (rough estimate)
- 굴절률
- 1.62 · 1.6200 (estimate)
- 저장 조건
- -20 °C · -20°C Freezer, Under inert atmosphere
- 용해도
- 클로로포름(약간 용해됨), DMSO(약간 용해됨), 메탄올(약간 용해됨)
- 물리적 상태
- 고체
- 색상
- 진한 주황색에서 매우 진한 주황색까지
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
Warning
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P261, P264, P270, P271, P301+P317, P304+P340, P317, P330, and P501 (click each P-code to see the statement)
The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
안전 데이터
- 독성
- LD50 i.p. in mice: 76 mg/kg (Hambourger)
화학 및 산업
약리 정보
MeSH Pharmacological Classification
Drugs that bind to but do not activate MUSCARINIC RECEPTORS, thereby blocking the actions of endogenous ACETYLCHOLINE or exogenous agonists. Muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, GI system, and salivary glands, GI motility, urinary bladder tone, and the central nervous system.
응용 분야
용도METHANTHELINE BROMIDE is a strong muscarinic receptor blocking drug used in the treatment of overactive bladder syndrome, hypersalivation and hyperhidrosis.
일반 설명Methanthelinebromide, diethyl(2-hydroxyethyl)methylammonium bromidexanthene-9-carboxylate (Banthine Bromide), is awhite, slightly hygroscopic, crystalline salt that is solublein water to produce solutions with a pH of about 5.Aqueous solutions are not stable and hydrolyze in a fewdays. The bromide form is preferable to the very hygroscopicchloride.Among the conditions for which methantheline bromideis indicated are gastritis, intestinal hypermotility, bladderirritability, cholinergic spasm, pancreatitis, hyperhidrosis,and peptic ulcer, all of which are manifestations ofparasympathotonia.
공급사17 곳
国药集团化学试剂有限公司86-21-63210123 · [email protected]
Shaanxi LonierHerb Bio Technology Co Ltd+86-86-+86-86-029-87551862 15002946897 · [email protected]
杭州摩库生物医药科技有限公司+86-057181025280; +8617767106207 · [email protected]
Dayang Chem (Hangzhou) Co.,Ltd.+86-0571-88938639 17705817739 · [email protected]
广州爱纯医药科技有限公司
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