페니실린 G 프로카인
페니실린G프로카인 · PENICILLIN G PROCAINE · PROCAINE BENZYLPENICILLIN · benzylpenicillin procaine · Benzyl Pencillin Procaine · benzylpenicillin novocaine salt · duphapen · depocillin
식별자 및 물리적 특성
| CAS No. | 54-35-3 |
|---|---|
| 분자식 | C29H38N4O6S |
| 평균 분자량 | 570.7 g/mol |
| 단동위원소 질량 | 570.25120594 g/mol |
| SMILES | CC1(C)S[C@@H]2[C@H](NC(=O)Cc3ccccc3)C(=O)N2[C@H]1C(=O)O.CCN(CC)CCOC(=O)c1ccc(N)cc1 |
| InChIKey | WHRVRSCEWKLAHX-LQDWTQKMSA-N |
| PubChem CID | 5903 |
| ChEMBL | CHEMBL1200936 |
| DTXSID | DTXSID30883227 |
| 현지명 | 페니실린 G 프로카인 |
화학 및 물리적 성질
| 극성 표면적 | 168 |
|---|---|
| 수소 결합 공여자 수 | 3 |
| 수소 결합 수용자 수 | 9 |
| 회전 가능 결합 수 | 11 |
| 무거운 원자 수 | 40 |
| 형식 전하 | 0 |
| 복잡도 | 752 |
| 용해도 | Slightly solubleDMSO: 100 mg/mL (175.22 mM)Ethanol: 20 mg/mL (35.04 mM) |
| Human Drugs | Breast FeedingLactationMilk, HumanAnti-Infective AgentsAntibacterial AgentsPenicillinsFDA approved drugs -> Active ingredientAccess group antibiotics |
| Animal Drugs | Active Ingredients (Penicillin G Procaine) -> FDA GreenbookPharmaceuticals -> UK Veterinary Medicines Directorate List |
| 녹는점 | 129-130 °C |
| 밀도 | 1.1335 (rough estimate) |
| 굴절률 | 1.6000 (estimate) |
| 저장 조건 | Store at -20°C |
| 용해도 | Water: 10 mg/mL (17.52 mM) |
| InChIKey | WHRVRSCEWKLAHX-RLWRCNEPNA-N |
| SMILES | N12[C@@H](C(=O)O)C(C)(C)S[C@@]1([C@H](NC(CC1C=CC=CC=1)=O)C2=O)[H].C1(=CC=C(N)C=C1)C(=O)OCCN(CC)CC |&1:1,9,10,r| |
| EPA | 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]- (2S,5R,6R)-, compd. with 2-(diethylamino)ethyl 4-aminobenzoate (1:1) (54-35-3) |
화학적 성질
White, fine crystals or powder; odorless; relatively stable to air and light; solutions dextroro- tatory. Sparingly soluble in water; slightly soluble in alcohol; fairly soluble in chloroform.
안전 및 규제
| 기타 안전 정보 | IMAP assessments - 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]- [2S-(2.alpha.,5.alpha.,6.beta.)]-, compound with 2-(diethylamino)ethyl 4-aminobenzoate (1:1): Environment tier I assessment |
|---|---|
| Effects During Pregnancy and Lactation | ◉ Summary of Use during Lactation |
| TSCA 등재 상태 | TSCA listed |
| 독성 | LD50 orl-rat: >2 g/kg ABANAE 3,534,55/56 |
| 기존화학 물질 | KE-05-1271 |
용도
용도
Antibacterial.
일반 설명
The first widely used amine salt of penicillin G wasmade with procaine. Penicillin G procaine (Crysticillin,Duracillin, Wycillin) can be made readily from penicillin Gsodium by treatment with procaine hydrochloride. This saltis considerably less soluble in water than the alkali metalsalts, requiring about 250 mL to dissolve 1 g. Free penicillinis released only as the compound dissolves and dissociates.It has an activity of 1,009 units/mg. A large number ofpreparations for injection of penicillin G procaine are commerciallyavailable. Most of these are either suspensions inwater to which a suitable dispersing or suspending agent, a buffer, and a preservative have been added or suspensions inpeanut oil or sesame oil that have been gelled by theaddition of 2% aluminum monostearate. Some commercialproducts are mixtures of penicillin G potassium or sodiumwith penicillin G procaine; the water-soluble salt providesrapid development of a high plasma concentration of penicillin,and the insoluble salt prolongs the duration of effect.