Liothyronine｜Huagongshe

Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용

HCID 5920생성일: 2026년 10월 27일

Liothyronine

https://huagongshe.com/ko/chemical/5920

Liothyronine 분자 구조식

식별자 및 물리적 특성

CAS No.	15785-49-6
분자식	C15H12I3NO4
평균 분자량	650.97 g/mol
단동위원소 질량	650.79005186 g/mol
SMILES	N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(=O)O
InChIKey	AUYYCJSJGJYCDS-LBPRGKRZSA-N
PubChem CID	5920
ChEMBL	CHEMBL1544
ChEBI	CHEBI:18258
EC No.	229-999-3
DTXSID	DTXSID8023216

화학 및 물리적 성질

XLogP	1.7
극성 표면적	92.8
수소 결합 공여자 수	3
수소 결합 수용자 수	5
회전 가능 결합 수	5
무거운 원자 수	23
형식 전하	0
복잡도	402
의약품	Pharmaceuticals -> Listed in ZINC15
LogP(분배 계수)	log Kow = 0.93
Color/Form	CRYSTALS
용해도	Very slightly solubleIn water, 3.958 mg/l at 37 °C.Soluble in dilute alkalies with the formation of a brownish, water-soluble, sodium salt. Insoluble in propylene glycol.11.4 [ug/mL] (The mean of the results at pH 7.4)
Human Drugs	Breast FeedingLactationMilk, HumanThyroid Hormones
Endocrine Disruptors	Potential endocrine disrupting compound
Decomposition	When heated to decomposition it emits toxic fumes of nitroxides, /hydrogen iodide/.
Optical Rotation	Optical rotation = +21.5 deg at 29.5 °C/D (c = 4.75 in a mixture of 1 part N hydrogen chloride + 2 parts ethanol).
Physical Description	Solid
Dissociation Constants	8.4

안전 및 규제

GHS 분류	WarningH315 (98.9%): Causes skin irritation [Warning Skin corrosion/irritation]P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 174 reports by companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
기타 안전 정보	IMAP assessments - L-Tyrosine, O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-: Environment tier I assessment
FDA 요건	Manufacturers, packers, and distributors of drug and drug products for human use are responsible for complying with the labeling, certification, and usage requirements as prescribed by the Federal Food, Drug, and Cosmetic Act, as amended (secs 201-902, 52 Stat. 1040 et seq., as amended21 U.S.C. 321-392).
Special Reports	Hays MTJ Clin Endocrinol 63: 527 (1970). Absorption of triiodothyronine in man.Surks MI, et alJ Clin Invest 52: 805 (1973). Determination of iodothyronine absorption and conversion to L-thyroxine (T4) to L-triiodothyronine (T3) using a rate turnover technique.
Hazard Classes and Categories	Skin Irrit. 2 (98.9%)
보관 조건	Commercially available liothyronine sodium tablets should be stored in tight containers at a temperature less than 40 °C, preferably between 15-30 °C. Commercially available liothyronine sodium injection should be stored at 2-8 °C. /Liothyronine sodium/
처리 방법	SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.
상호 작용	USE OF PROPRANOLOL IN CONJUNCTION WITH REPLACEMENT THERAPY HAS BEEN REPORTED TO DECR RISK OF ARRHYTHMIA & ANGINA...THYROID COMPOUNDS THAT PRODUCE HYPERMETABOLIC STATE (LIOTHYRONINE...) INCR RATE OF DECAY OF VITAMIN K-DEPENDENT CLOTTING FACTORS, & IN PRESENCE OF ORAL ANTICOAGULANTS /EG, WARFARIN/, NORMAL COMPENSATION BY INCR SYNTHESIS IS PREVENTED.

독성 요약

The hormones, T<sub>4</sub> and T<sub>3</sub>, are tyrosine-based hormones produced by the thyroid gland. Iodine is an important component in their synthesis. The major form of thyroid hormone in the blood is thyroxine (T<sub>4</sub>). This is converted to the more active liothyronine form by deiodinases in peripheral tissues. Liothyronine acts on the body to increase the basal metabolic rate, affect protein synthesis and increase the body's sensitivity to catecholamines (such as adrenaline). The thyroid hormones are essential to proper development and differentiation of all cells of the human body. To various extents T<sub>4</sub> and T<sub>3</sub> regulate protein, fat and carbohydrate metabolism. Their most pronounced effect is on how human cells use energetic compounds. The thyroid hormone derivatives bind to the thyroid hormone receptors initially to initiate their downstream effects.

Human Toxicity Excerpts

UNTOWARD EFFECTS OF OVERDOSES OF THYROID HORMONES INCL TACHYCARDIA...ANGINA PECTORIS, HYPERTENSION...HYPERKINESIS...GI DISTURBANCES, & HYPOADRENOCORTICISM. ...MAY CAUSE ALLERGIC REACTIONS. /THYROID HORMONES/FRANKLY TOXIC DOSES INDUCE UNPLEASANT BUT TRANSIENT SYMPTOMS THAT RESEMBLE THYROTOXICOSIS (THYROID STORM). SIGNS & SYMPTOMS INCL PALPITATIONS, RAPID & IRREGULAR PULSE, HEADACHE, TREMORS, NERVOUSNESS, INSOMNIA, DELIRIUM, DIAPHORESIS, HYPERPYREXIA, VOMITING (SOMETIMES UNCONTROLLABLE), COLLAPSE & COMA. /THYROID/LOW TOXICITY @ NORMAL DOSAGE.

Non-Human Toxicity Excerpts

IN RATS EXOPHTHALMOS HAS BEEN PRODUCED /BY USE OF LIOTHYRONINE/. IN RABBITS INTRAOCULAR PRESSURE HAS BEEN REDUCED 4 MM HG BY SUBCONJUNCTIVAL INJECTION OF TRIIODOTHYRONINE...Four pregnant New Zealand white rabbits received intramuscular triiodothyronine (LiothyronineT3) at 125 ug/kg on days 25 and 26 of gestation. Another group of 6 rabbits served as controls. Maternal and fetal plasma-free T3, thyroxine (T4), and glucose concentration, as well as fetal liver glycogen content, were evaluated on day 27 of gestation. In T3-treated rabbits, maternal and fetal plasma-free T3 concentration was higher than in controls. T3 treatment resulted in fetal hyperglycemia and depletion of fetal liver glycogen content.