4-니트로벤질수소말로네이트

Preparation of mono-4-nitrobenzyl malonate:In a flame-dried 150 mL pressure tube under argon, add 5.00 g (34.7 mmol) of Meldrum's acid and 40 mL of anhydrous MeCN.Add 5.58 g (36.4 mmol) of p-nitrobenzyl alcohol to the resulting solution.Cap the tube tightly and reflux the reaction overnight.Concentrate the reaction mixture under reduced pressure.Purify the residue using column chromatography with a 55/45 hexane/EtOAc mixture.The resulting product is mono-4-nitrobenzyl malonate with a yield of 87%.