Chloramphenicol

Synthomycin · CHLORONITRIN · CHLORAMPHENICOLUM · DL-Chloramphenicol · CHLORAMPHENICOL(RG) · CHLORAMPHENICOL LEVO · Chloramphenicol BP2000,CP2000 · DL-chloramphenicol Synthomycin

https://huagongshe.com/ko/chemical/5959

식별자 및 물리적 특성

CAS No.	2787-09-9
분자식	C11.H12.Cl2.N2.O5
평균 분자량	323.13 g/mol
단동위원소 질량	322.01232684 g/mol
SMILES	O=C(N[C@H](CO)[C@H](O)c1ccc([N+](=O)[O-])cc1)C(Cl)Cl
InChIKey	WIIZWVCIJKGZOK-RKDXNWHRSA-N
PubChem CID	5959
ChEMBL	CHEMBL130
ChEBI	CHEBI:17698
EC No.	200-287-4
DTXSID	DTXSID7020265

화학 및 물리적 성질

XLogP	1.1
극성 표면적	115
수소 결합 공여자 수	3
수소 결합 수용자 수	5
회전 가능 결합 수	5
무거운 원자 수	20
형식 전하	0
복잡도	342
물질 분류	Other Uses -> Pharmaceuticals
의약품	Pharmaceuticals -> AntibioticsPharmaceuticals -> Antibiotics (Amphenicols)Pharmaceuticals -> Listed in ZINC15
pH	Neutral to litmus
LogP(분배 계수)	log Kow = 1.140.7
맛	Bitter to taste
Color/Form	Needles or elongated plates from water or ethylene dichlorideWhite to greyish-white or yellowish-white fine crystalline powder or fine crystals, needles or elongated plates. Of the four possible stereoisomers, only the alphaR,betaR (or D-threo) form is active ... .Pale yellow plates or needles from water
용해도	In water, 2.5 mg/mL at 25 °CSolubility in propylene glycol: 150.8 mg/mol. Very sol in methanol, ethanol, butanol, ethyl acetate, acetone. Fairly soluble in ether. Insoluble in benzene, petroleum ether, vegetable oils. Solubility in 50% acetamide solution about 5%.Very soluble in acetone, chloroform, ethanol4.61e-01 g/L
Human Drugs	Breast FeedingLactationAnti-Infective AgentsAntibacterial AgentsFDA approved drugs -> Active ingredientAccess group antibiotics
Animal Drugs	Active Ingredients (Chloramphenicol) -> FDA GreenbookPharmaceuticals -> Animal Drugs -> Approved in Taiwan
끓는 점	Sublimes in high vacuum644.9±55.0 °C(Predicted)
Decomposition	When heated to decomposition it emits very toxic fumes of /nitrogen oxides and chloride/.
녹는점	150.5-151.5 °CMP: 149-153 °C150.5 °C151 °C148-150 °C(lit.)
밀도	1.547±0.06 g/cm3(Predicted)
저장 조건	2-8°C
물리적 상태	가루
pKa(산도 계수)	11.03±0.46(Predicted)
색상	하얀색
InChI	InChI=1/C11H12Cl2N2O5/c12-10(13)11(18)14-8(5-16)9(17)6-1-3-7(4-2-6)15(19)20/h1-4,8-10,16-17H,5H2,(H,14,18)/t8-,9-/s3
InChIKey	WIIZWVCIJKGZOK-JQEWEITDNA-N
SMILES	C(N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1)(=O)C(Cl)Cl \|&1:2,5,r\|

안전 및 규제

GHS 분류	This chemical does not meet GHS hazard criteria for 2% (6 of 294) of reports.DangerH317 (18%): May cause an allergic skin reaction [Warning Sensitization, Skin]P203, P261, P264+P265, P272, P280, P302+P352, P305+P354+P338, P317, P318, P321, P333+P317, P362+P364, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 294 reports by companies from 32 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
규제 정보	Hazard Traits - CarcinogenicityStatus: Active Update: 30-05-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/26156Chloramphenicol: Does not have an individual approval but may be used under an appropriate group standard
기타 안전 정보	IMAP assessments - Acetamide, 2,2-dichloro-N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]-, [R-(R,R)]-: Environment tier I assessment
유해성 요약	Allergic contact dermatitis reported in pharmaceutical workers[Marks, p. 189-90] Chloramphenicol is an antibiotic, and many side effects have been reported after ingestion of therapeutic doses including, rarely, bone marrow suppression. [HSDB] The lowest dose to cause reversible bone marrow depression was 2000 mg/day for 21 days. While the reversible bone marrow depression is dose related, the rare aplastic anemia is not dose related and is thought to be an idiosyncratic reaction in susceptible individuals. IARC has noted cases of leukemia developing in patients suffering from chloramphenicol-induced aplastic anemia. Occupational allergic dermatitis reported in ophthalmologists and farmers using topical chloramphenicol solutionsNo evidence of significant skin absorptionToxic to embryos and fetuses in animal studies at 1000 mg/kg-day[AIHA]
FDA 요건	The Approved Drug Products with Therapeutic Equivalence Evaluations identifies currently marketed prescription drug products, including chloramphenicol sodium succinate, approved on the basis of safety and effectiveness by FDA under sections 505 of the Federal Food, Drug, and Cosmetic Act. /Chloramphenicol sodium succinate/The Generic Animal Drug and Patent Restoration act requires that each sponsor of an approved animal drug must submit to the FDA certain information regarding patents held for the animal drug or its method of use. The Act requires that this information, as well as a list of all animal drug products approved for safety and effectiveness, be made available to the public. Chloramphenicol is included on this list.

용도

DL-Chloramphenicol is an antibiotic drug.