기본 정보
- CAS
103475-41-8- 표준 SMILES
COc1ccc(-n2nc(CCC(=O)N(C)O)cc2-c2ccc(Cl)cc2)cc1- InChIKey
XYKWNRUXCOIMFZ-UHFFFAOYSA-N- 분자식
- C20H20ClN3O3
- 평균 분자량
- 385.8 g/mol
- 단동위원소 질량
- 385.1193192
이름 및 식별자
- 우선 이름
- Tepoxalin
- IUPAC
- 3-[5-(4-chlorophenyl)-1-(4-methoxyphenyl)pyrazol-3-yl]-N-hydroxy-N-methylpropanamide
- 현지명
- 테폭살린
- 영어명
- Tepoxalin
- 분자식
- C20H20ClN3O3
- 분자량
- 385.849
이름 및 동의어
TEPOXALIN103475-41-8TepoxalineZubrinOrf-20485ORF 20485TepoxalinaRWJ 20485Tepoxalinum5-(4-Chlorophenyl)-N-hydroxy-1-(4-methoxyphenyl)-N-methyl-1H-pyrazole-3-propanamideRWJ-20485DTXSID1057610
이름 더 보기
테폭살린epoxalinTepoxalin, 10 mM in DMSOinhibit,Lipoxygenase,LOX,Inhibitor,COX,Tepoxalin,Cyclooxygenase3-(5-(4-chlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazol-3-yl)-N-hydroxy-N-methylpropanamide3-[1-(4-Methoxyphenyl)-5-(4-chlorophenyl)-1H-pyrazol-3-yl]-N-hydroxy-N-methylpropanamide
5-(p-Chlorophenyl)-1-(p-methoxyphenyl)-N-methylpyrazole-3-propionohydroxamic acid1H-Pyrazole-3-propanamide, 5-(4-chlorophenyl)-N-hydroxy-1-(4-methoxyphenyl)-N-methyl-TZ4OX61974DTXCID5031399CHEBI:76277Zubrin Rapidly-Disintegrating Tablets3-[5-(4-chlorophenyl)-1-(4-methoxyphenyl)pyrazol-3-yl]-N-hydroxy-N-methylpropanamide3-(5-(4-chlorophenyl)-1-(4-methoxyphenyl)pyrazol-3-yl)-N-hydroxy-N-methylpropanamide
데이터베이스 식별자
- CAS
103475-41-8- PubChem CID
- 59757
- DTXSID
DTXSID1057610- ChEMBL
CHEMBL316040- ChEBI
CHEBI:76277- UNII
- TZ4OX61974
- EC Number
- 638-877-2
- Nikkaji
- J357.517I
물성
구조 계산 물성
- XLogP
- 3.4
- 극성 표면적
- 67.6 Ų
- 수소 결합 공여자 수
- 1
- 수소 결합 수용자 수
- 4
- 회전 가능 결합 수
- 6
- 무거운 원자 수
- 27
- 형식 전하
- 0
- 복잡도
- 479
물리화학적 성질
- 녹는점
- 124 · 124-126°
- 저장 조건
- Hygroscopic, Refrigerator, Under Inert Atmosphere
- 용해도
- DMSO(적게), 메탄올(약간)에 용해됨
- 물리적 상태
- 고체
- 색상
- 흰색에서 옅은 갈색까지
- 안정성
- 흡습성
화학적 성질
Off-White Solid
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
Warning
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 11 reports by companies from 1 notifications to the ECHA C&L Inventory.；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.
유해성 정보
Regulatory InformationTepoxalin: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
Hazard Classes and CategoriesAcute Tox. 4 (100%)
규제 정보
Regulatory InformationTepoxalin: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
안전 데이터
- 신호 어
- Warning
- 유해·위험 문구
- 암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드 H302
화학 및 산업
약리 정보
ATC CodeQM - Musculo-skeletal system；QM01 - Antiinflammatory and antirheumatic products；QM01A - Antiinflammatory and antirheumatic products, non-steroids；QM01AE - Propionic acid derivatives；QM01AE92 - Tepoxalin
MeSH Pharmacological Classification
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
용도 및 제조
Use ClassificationAnimal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients
응용 분야
용도Tepoxalin is non-steroidal anti-inflammatory drug (NSAID) with potent anti-inflammatory and analgesic properties approved for veterinary use. It has inhibitory effect on cyclooxygenase and 5-lipxygenase activity a s well as inhibiting the production of cytokines in peripheral cells outside the CNS.
상·하류 제품 정보
상류 원료
관련 반응
5건
화합물 노트
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