| GHS 분류 | This chemical does not meet GHS hazard criteria for 1.5% (1 of 67) of reports.WarningH302 (94%): Harmful if swallowed [Warning Acute toxicity, oral]P264, P270, P280, P301+P317, P302+P352, P321, P330, P332+P317, P362+P364, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 67 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
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| 규제 정보 | Chemical: 2-Propanol, 1,1,1-trichloro-2-methyl-Status: Active Update: 24-04-2019 https://echa.europa.eu/registration-dossier/-/registered-dossier/256312-Propanol, 1,1,1-trichloro-2-methyl-hydrate: Does not have an individual approval but may be used under an appropriate group standard |
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| 기타 안전 정보 | IMAP assessments - 2-Propanol, 1,1,1-trichloro-2-methyl-: Human health tier I assessment |
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| 화재 가능성 | COMBUSTIBLE WHEN EXPOSED TO HEAT OR FLAME. |
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| 유해성 요약 | A skin and eye irritant0.4% solution caused keratitis in rabbit eyes following continuous bathingEmergency treatment is for chloral hydrate and related agents. [HSDB]See Chlorobutanol. |
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| FDA 요건 | Manufacturers, packers, and distributors of drug and drug products for human use are responsible for complying with the labeling, certification, and usage requirements as prescribed by the Federal Food, Drug, and Cosmetic Act, as amended (secs 201-902, 52 Stat. 1040 et seq., as amended21 U.S.C. 321-392).Chloretone is a chemical derivative of chloral, named in section 502(d) of the Federal Food, Drug, and Cosmetic Act and is hereby designated as habit forming. |
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| Hazard Classes and Categories | Acute Tox. 4 (94%)Acute Tox. 4 (100%) |
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| Skin, Eye, and Respiratory Irritations | A skin and eye irritant. |
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| 보관 조건 | IN GENERAL, MATERIALS WHICH ARE TOXIC AS STORED OR WHICH CAN DECOMP INTO TOXIC COMPONENTS ... SHOULD BE STORED IN A COOL, WELL-VENTILATED PLACE, OUT OF DIRECT RAYS OF THE SUN, AWAY FROM AREAS OF HIGH FIRE HAZARD, & SHOULD BE PERIODICALLY INSPECTED ... INCOMPATIBLE MATERIALS SHOULD BE ISOLATED FROM EACH OTHER. |
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| 처리 방법 | SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices. |
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| Preventive Measures | SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place. |
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| 유해 작용 | Neurotoxin - Acute solvent syndrome |
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| Human Toxicity Excerpts | ...SOLN CONTAINING...0.4% CHLOROBUTANOL...UNDER CONTACT LENS...LEFT ON EYE FOR SEVERAL MIN...UNCOMFORTABLE KERATITIS EPITHELIALIS HAS RESULTED, WITH FOGGING OF VISION, HALOES AROUND LIGHTS, & FOREIGN-BODY TYPE OF DISCOMFORT BEGINNING WITHIN HR & BECOMING WORSE...EYES HAVE RECOVERED SPONTANEOUSLY & COMPLETELY IN DAY OR TWO.This substance may be habit forming ... |
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| Non-Human Toxicity Excerpts | EXPT ON EXCISED ANIMAL CORNEAS HAVE SHOWN THAT CHLOROBUTANOL INHIBITS OXYGEN UPTAKE & REDUCES ADHESION OF EPITHELIUM TO CORNEAL STROMA...EXPT ON RABBITS...AFTER APPLICATION OF...LOCAL ANESTHETIC...BATHING EYES CONTINUOUSLY FOR 20 MIN WITH AQ SOLN CONTAINING...0.4% CHLOROBUTANOL PRODUCES DEFINITE KERATITIS EPITHELIALIS...IN CORNEA. ... FRESHLY PREPD SOLN @ PH 5.5 HAS CAUSED VISIBLE KERATITIS EPITHELIALIS AFTER 5 TO 10 MIN OF BATHING.CHLOROBUTANOL CAUSED 30% DECR IN CONTRACTION AMPLITUDE & 20% INCR IN ACTION-POTENTIAL DURATION. LOWERED CONDUCTION VELOCITY & INDUCED CONDUCTION FAILURE & AUTOMATICITY WITHIN ISOLATED VENTRICULAR MUSCLE STRIPS.INCR URINARY & HEPATIC CONCN OF D-GLUCURONIC ACID, L-ASCORBIC ACID, & D-GLUCARIC ACID WERE FOUND WITHIN 8 HR AFTER ADMIN OF CHLORBUTOL TO RATS.MALE RATS KEPT ON NORMAL DIETS SUPPLEMENTED WITH CHLORETONE (0.04%) PRODUCED CHOLESTEROLEMIC ACTIVITY, SIGNIFICANT INCR IN URINARY EXCRETION OF ASCORBIC ACID WAS FOUND WITH COEFFICIENT OF ANILINE HYDROXYLASE ACTIVITY OF 0.84. |
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| TSCA 등재 상태 | TSCA listed |
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