Zofran (HCID 59774)｜Huagongshe

개요

Ondansetron hydrochloride is a member of carbazoles.

이름 및 식별자

우선 이름: Zofran
IUPAC: 9-methyl-3-[(2-methylimidazol-1-yl)methyl]-2,3-dihydro-1H-carbazol-4-one;dihydrate;hydrochloride
영어명: Ondansetron hydrochloride
분자식: C18H22ClN3O2
분자량: 347.84

이름 및 동의어

ZofranRefChem:934563Ondansetron hydrochloride dihydrate103639-04-9Ondansetron hydrochloride hydrateSetrodonDTXSID90488579-methyl-3-[(2-methylimidazol-1-yl)methyl]-2,3-dihydro-1H-carbazol-4-one;dihydrate;hydrochlorideGR-38032FMFCD00374371CHEBI:7774DTXCID6028783

이름 더 보기

AKOS NCG1-0013ondansetron hydOndansetronHclUsp28Ondansetron hydrochlODANSETRON HYDROCHLORIDEOndansetron hydrochloridOndansetronHClmonohydrateOndansetron hydrochlorideGR 38032SN 307NSC 665799Ondansetron impurity A CRS

Ondansetron (hydrochloride dihydrate)9-Methyl-3-((2-methyl-1H-imidazol-1-yl)methyl)-1,2,3,9-tetrahydro-4H-carbazol-4-one hydrochloride dihydrateKS-1091ONDANSETRON HYDROCHLORIDE [MART.]CAS-103639-04-94H-Carbazol-4-one,1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-,monohydrochloride, dihydrateUNII-NMH84OZK2BZensana

데이터베이스 식별자

CAS: 103639-04-9
PubChem CID: 59774
DTXSID: DTXSID9048857
ChEBI: CHEBI:7774
UNII: NMH84OZK2B
EC Number: 600-465-5

물성

구조 계산 물성

극성 표면적: 41.8 Å²
수소 결합 공여자 수: 3
수소 결합 수용자 수: 4
회전 가능 결합 수: 2
무거운 원자 수: 25
형식 전하: 0
복잡도: 440

실험 및 물리화학적 성질

Human DrugsBreast Feeding; Lactation; Milk, Human; Antiemetics; Gastrointestinal Agents; Serotonin Antagonists; Serotonin 5-HT3 Receptor Antagonists

물리화학적 성질

녹는점: 231 · 231-232 C
저장 조건: -20 °C · -20°C
용해도: 2 O: · H2O: >5mg/mL
물리적 상태: 가루
색상: 하얀색
수용성: 2 O: · H2O: >5mg/mL
InChI: InChI=1S/C18H19N3O.ClH.H2O/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2;;/h3-6,9-10,13H,7-8,11H2,1-2H3;1H;1H2
InChIKey: FELGMEQIXOGIFQ-ZDUSSCGKSA-N
SMILES: O=C1C(CCC2N(C)C3=CC=CC=C3C1=2)CN1C=CN=C1C.Cl.O

화학적 성질

White or almost white powder.

안전 및 규제

GHS 분류

GHS Classification · 4건

Danger

H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]

P264, P264+P265, P270, P273, P280, P301+P316, P305+P351+P338, P305+P354+P338, P317, P321, P330, P337+P317, P391, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 117 reports by companies from 16 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

유해성 정보

Hazard Classes and CategoriesAcute Tox. 3 (100%)

독성 정보

TreatmentThere is no specific antidote for ondansetron overdose. Patients should be managed with appropriate supportive therapy. (L1712)

Exposure RoutesOndansetron is well absorbed after oral administration and undergoes limited first-pass metabolism.

Toxicity Summary · 1건

Ondansetron is a selective serotonin 5-HT3 receptor antagonist. The antiemetic activity of the drug is brought about through the inhibition of 5-HT3 receptors present both centrally (medullary chemoreceptor zone) and peripherally (GI tract). This inhibition of 5-HT3 receptors in turn inhibits the visceral afferent stimulation of the vomiting center, likely indirectly at the level of the area postrema, as well as through direct inhibition of serotonin activity within the area postrema and the chemoreceptor trigger zone.

Signs and SymptomsLow blood pressure and fainting, sudden blindness, severe constipation

Carcinogen ClassificationNo indication of carcinogenicity to humans (not listed by IARC).

Effects During Pregnancy and Lactation◉ Summary of Use during Lactation

안전 데이터

wgk: 3
rtecs: FE6375500
ridadr: UN 2811
HS 번호: 2933290000
risk_code: 25-36/37/38-50/53-41
hazard_code: T,Xi
safety_code: 45-37/39-26-61-39
포장분류: III
위험 등급: 6.1
Hazard Classifications: Acute Tox. 3 OralAquatic Acute 1Aquatic Chronic 2Eye Dam. 1
스토리지 클래스: 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects

화학 및 산업

약리 정보

Metabolism/MetabolitesHepatic Half Life: 5.7 hours

MeSH Pharmacological Classification · 3건

Drugs used to prevent NAUSEA or VOMITING.

Agents, usually topical, that relieve itching (pruritus).

Drugs that bind to but do not activate SEROTONIN 5-HT3 RECEPTORS, thereby blocking the actions of SEROTONIN or SEROTONIN 5-HT3 RECEPTOR AGONISTS.

용도 및 제조

UsesFor the prevention of nausea and vomiting associated with emetogenic cancer chemotherapy, postoperation, and radiation. Also used for the treatment of postoperative nausea and vomiting.

응용 분야 · 3건

개요Ondansetron hydrochloride is a selective 5HT3-antagonist approved for the management of nausea and vomiting induced by cancer chemotherapy and radiotherapy. It is reported to have a superior side-effect profile compared with metoclopramide, representing an important advance in the treatment of nausea and vomiting associated with chemotherapy. Ondansetron hydrochloride is the first specific 5HT3-antagonist to reach the market. It is also under investigation for a number of other indications, including anxiety and schizophrenia.

용도Ondansetron hydrochloride dihydrate has been used as a 5-HT3 antagonist to attenuate rostro ventromedial medulla (RVM)/cholecystokinin (CCK)-induced mechanical hypersensitivity and to block the effects of trichostatin A (TSA) on 5-HT3 protein.

일반 설명Ondansetron Hydrochloride acts as a 5HT3 (serotonin) antagonist and is a powerful antiemetic drug. It is widely used for the prevention and treatment of nausea and vomiting related to post-operative states, cancer chemotherapy and radiotherapy, and chronic medical illness. It has been found to exhibit inconsistent bioavailability resulting from its poor aqueous solubility and high first-pass hepatic metabolism.Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.