Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
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식별자 및 물리적 특성
| CAS No. | 5329-14-6 |
|---|---|
| 분자식 | H3NO3S |
| 평균 분자량 | 97.1 g/mol |
| 단동위원소 질량 | 96.98336413 g/mol |
| SMILES | NS(=O)(=O)O |
| InChIKey | IIACRCGMVDHOTQ-UHFFFAOYSA-N |
| PubChem CID | 5987 |
| ChEBI | CHEBI:9330 |
| EC No. | 226-218-8 |
| DTXSID | DTXSID6034005 |
| 현지명 | 설파믹산 |
화학 및 물리적 성질
| XLogP | -1.6 |
|---|---|
| 극성 표면적 | 88.8 |
| 수소 결합 공여자 수 | 2 |
| 수소 결합 수용자 수 | 4 |
| 회전 가능 결합 수 | 0 |
| 무거운 원자 수 | 5 |
| 형식 전하 | 0 |
| 복잡도 | 92 |
| pH | 1N, pH=0.410.75N, pH=0.50.5N, pH=0.630.25N, pH=0.870.1N, pH=1.180.05N, pH=1.410.01N, pH=2.021.2 (10g/l, H2O) |
| LogP(분배 계수) | 0.10 |
| 냄새 | ODORLESS냄새 없는 |
| 밀도 | 2.15Relative density (water = 1): 2.12.15 @25 °C2.151 g/cm3 at 25 °C |
| Color/Form | ORTHORHOMBIC CRYSTALSWHITE CRYSTALLINE SOLIDGranular grade is off-white in color |
| 용해도 | SPARINGLY SOL IN ALC, METHANOLSLIGHTLY SOL IN ACETONEINSOL IN ETHERFREELY SOL IN NITROGENOUS BASES AND IN NITROGEN CONTAINING ORG SOLVENTSINSOL IN CARBON DISULFIDE & CARBON TETRACHLORIDE12.8 wt% in water at 0 °C17.57 wt% in water at 20 °C22.77 wt% in water at 40 °C0.1667 wt% in formamide at 25 °C0.0412 wt% in methanol at 25 °C0.0167 wt% in ethanol (2% benzene) at 25 °C0.0040 wt% in acetone at 25 °C0.0001 wt% in ether at 25 °Cwater solubility = 1.47X10+5 mg/l @ 0 °C147 mg/mL at 0 °CSolubility in water at 20 °C: freely soluble물: 20°C에서 용해성213g/L |
| Corrosivity | H2SO4 (3wt%) and HCl (3wt%) are 2.6 and 4.2 times more corrosive, respectively, than a 3 wt% solution of sulfamic acid on 1010 steel. On the same scale, H2SO4 and HCl (3wt% solutions) are 1.5 and 6.7, respectively, times more corrosive on copper1.5 and 2.8 more corrosive on brass4.0 and 7.0 more corrosive on bronze0.6 and 5.3 more corrosive on aluminum. |
| 끓는 점 | DECOMP @ BOILING POINT-520.47°C (estimate) |
| Decomposition | WHEN HEATED TO DECOMP, IT EMITS HIGHLY TOXIC FUMES OF /SULFUR OXIDES & HYDROGEN CHLORIDE/.~205 °C |
| 녹는점 | Melting point equals 205 °C215-225 °C (dec.) (lit.) |
| Heat of Combustion | 1.53x10+7 J/kmol |
| Physical Description | Sulfamic acid appears as a white crystalline solid. Density 2.1 g / cm3. Melting point 205 °C. Combustible. Irritates skin, eyes, and mucous membranes. Low toxicity. Used to make dyes and other chemicals.LiquidOther SolidDry PowderLarge CrystalsCBIWhite crystals[CAMEO]ODOURLESS COLOURLESS CRYSTALS OR POWDER. |
| 증기압 | 0.8Pa at 20℃ |
| 굴절률 | 1.553 |
| 저장 조건 | Store below +30°C. |
| 물리적 상태 | 결정 또는 결정성 분말 |
| pKa(산도 계수) | -8.53±0.27(Predicted) |
| 색상 | 하얀색 |
| 용해도 | 146.8g/L(20℃) |
| Merck | 14,8921 |
| 안정성 | 안정적인. |
| 주요 응용 | 환경음식 및 음료일반 분석산업 품질 관리제약 |
| InChI | 1S/H3NO3S/c1-5(2,3)4/h(H3,1,2,3,4) |
| InChIKey | IIACRCGMVDHOTQ-UHFFFAOYSA-N |
| SMILES | NS(O)(=O)=O |
| LogP(분배 계수) | 0 at 20℃ |
| NIST | Sulfamic acid(5329-14-6) |
| EPA | Sulfamic acid (5329-14-6) |
화학적 성질
Sulfamic acid is a white orthorhombic flaky crystal, odorless, non-volatile and non-hygroscopic. Soluble in water and liquid ammonia, slightly soluble in methanol, insoluble in ethanol and ether, also insoluble in carbon disulfide and liquid sulfur dioxide. Its aqueous solution has the same strong acid properties as hydrochloric acid and sulfuric acid, but its corrosiveness to metals is much lower than that of hydrochloric acid. The toxicity is extremely small, but it should not be in contact with the skin for a long time, and it should not enter the eyes.
안전 및 규제
| GHS 분류 | WarningH315: Causes skin irritation [Warning Skin corrosion/irritation]H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]H412: Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]P264, P264+P265, P273, P280, P302+P352, P305+P351+P338, P321, P332+P317, P337+P317, P362+P364, and P501 (click each P-code to see the statement)This chemical does not meet GHS hazard criteria for 2.7% (104 of 3920) of reports. |
|---|---|
| 규제 정보 | Chemical: Sulfamic acidSulfamic acid is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Sulfamic acid are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 28-10-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/14842Status: Active Update: 11-03-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/22327Sulfamic acid: HSNO Approval: HSR001549 Approved with controlsThe New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.) |
| 기타 안전 정보 | IMAP assessments - Sulfamic acid: Human health tier I assessmentIMAP assessments - Sulfamic acid: Environment tier I assessment |
| 운송 라벨(DOT) | Corrosive |
| 화재 위험 | Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Corrosives in contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. For electric vehicles or equipment, ERG Guide 147 (lithium ion or sodium ion batteries) or ERG Guide 138 (sodium batteries) should also be consulted. (ERG, 2024)· Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.· Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.).· Corrosives in contact with metals may evolve flammable hydrogen gas.· Containers may explode when heated.· For electric vehicles or equipment, GUIDE 147 (lithium ion or sodium ion batteries) or GUIDE 138 (sodium batteries) should also be consulted.Combustible under specific conditions. Gives off irritating or toxic fumes (or gases) in a fire. Risk of explosion on contact with incompatible substances. See Chemical Dangers. |
| 건강 유해성 | Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:TOXIC and/or CORROSIVEinhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause environmental contamination. (ERG, 2024)· TOXIC and/or CORROSIVEinhalation, ingestion or skin contact with material may cause severe injury or death.· Contact with molten substance may cause severe burns to skin and eyes.· Avoid any skin contact.· Fire may produce irritating, corrosive and/or toxic gases.· Runoff from fire control or dilution water may be corrosive and/or toxic and cause environmental contamination. |
| 유해성 요약 | A skin and eye irritantMolten substance may cause severe burns to the eyes and skin[CAMEO] A strong acidSlowly hydrolyzes to ammonium bisulfate in solution[Merck Index] No active registrants[NPIRS] Corrosive to the skin and eyesInhalation of aerosol can produce pulmonary edemaNitrogen oxides and sulfur oxides are released when heated to decomposition[ICSC] Moderately toxic by ingestionApplication of 0.5 ml. of a 4% solution into the eyes of a rabbit caused conjunctivitis, but no serious injury[HSDB] Corrosive to skin and mucous membranesInhalation may induce chemical pneumonitis[MSDSonline] |
| 운송 번호 및 가이드(DOT) | 2967 154 |
| 반응성 그룹 | Acids, Strong Non-oxidizing |
| UN 분류 | UN Hazard Class: 8UN Pack Group: III |
| EPA Safer Chemical | Chemical: Sulfamic acidGreen circle - The chemical has been verified to be of low concern based on experimental and modeled data. |
| FIFRA 요건 | As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their future use. Under this pesticide reregistration program, EPA examines health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether they are eligible for reregistration. In addition, all pesticides must meet the new safety standard of the Food Quality Protection Act of 1996. Pesticides for which EPA had not issued Registration Standards prior to the effective date of FIFRA, as amended in 1988, were divided into three lists based upon their potential for human exposure and other factors, with List B containing pesticides of greater concern and List D pesticides of less concern. Sulfamic acid is found on List D. Case No: 4085Pesticide type: antimicrobialCase Status: None of the active ingredients in the case are being supported for reregistration by their registrants. All are unsupported, or some are unsupported and some are cancelled. Cases described as "unsupported" generally are being processed for cancellation.Active ingredient (AI): Sulfamic acidAI Status: Registrants of the pesticide have not made or honored a commitment to seek reregistration, conduct the necessary studies, or pay the requisite fees, or they have asked EPA to cancel their product registrations. Unless some other interested party supports them, products containing the pesticide will be cancelled.A tolerance is established for residues of sulfamate ion, expressed as sulfamic acid, from the postharvest application of the fungicide chlorosulfamic acid in or on asparagus, carrots, cauliflower, celery, potatoes, and radishes. |
| Reactivity Alerts | Known Catalytic Activity |
| 소화 | Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:SMALL FIRE: Dry chemical, CO2 or water spray.LARGE FIRE: Dry chemical, CO2, alcohol-resistant foam or water spray. If it can be done safely, move undamaged containers away from the area around the fire. Dike runoff from fire control for later disposal.FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Do not get water inside containers. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. (ERG, 2024)Use water spray, foam, powder, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water. |
| 응급 조치 | Fresh air, rest. Seek medical attention if you feel unwell.Rinse skin with plenty of water or shower. Refer for medical attention if skin irritation occurs.Rinse with plenty of water for several minutes (remove contact lenses if easily possible). Refer immediately for medical attention.Rinse mouth. Give one or two glasses of water to drink. Seek medical attention if you feel unwell. |
| 누출 비상 조치 | · CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.· Keep unauthorized personnel away.· Stay upwind, uphill and/or upstream.· Ventilate closed spaces before entering, but only if properly trained and equipped.· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.· Do not touch damaged containers or spilled material unless wearing appropriate protective clothing.· Stop leak if you can do it without risk.· Prevent entry into waterways, sewers, basements or confined areas.· Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers.· DO NOT GET WATER INSIDE CONTAINERS. |
| 응급 처치 | Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:Refer to the "General First Aid" section. Specific First Aid: For corrosives, in case of contact, immediately flush skin or eyes with running water for at least 30 minutes. Additional flushing may be required. (ERG, 2024)General First Aid:· Call 911 or emergency medical service.· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.· Move victim to fresh air if it can be done safely.· Administer oxygen if breathing is difficult.· If victim is not breathing:-- DO NOT perform mouth-to-mouth resuscitationthe victim may have ingested or inhaled the substance.-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.· Remove and isolate contaminated clothing and shoes.· For minor skin contact, avoid spreading material on unaffected skin.· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.· For severe burns, immediate medical attention is required.· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.· Keep victim calm and warm.· Keep victim under observation.· For further assistance, contact your local Poison Control Center.· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.Specific First Aid:· For corrosives, in case of contact, immediately flush skin or eyes with running water for at least 30 minutes. Additional flushing may be required. |
| 안전 보관 | Store only in original container. Separated from food and feedstuffs and incompatible materials. See Chemical Dangers. Dry. Store in an area without drain or sewer access. |
| 노출 관리 및 개인 보호 | · Wear positive pressure self-contained breathing apparatus (SCBA).· Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE.· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection. |
| 소화 절차 | If material on fire or involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use dry chemical, dry sand, or carbon dioxide. Do not use water on material itself. If large quantities of combustibles are involved, use water in flooding quantities as spray and fog. |
| 정리 방법 | Wear eye protection, laboratory coat and nitrile rubber gloves. Clean up with dust pan and brush. May be flushed away to waste with at least 50 vol of water or mixed with sand and disposed or as normal refuse. |
| 비화재 누출 대응 | Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS. (ERG, 2024) |
| 처리 방법 | SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.Package Lots: Place in a separate labeled container for recycling or disposal by burning in a furnace equipped with an afterburner and scrubber. Small Quantities: Wear eye protection, laboratory coat and nitrile rubber gloves. Work in the fume hood. Sift slowly into a large container of cold water, with agitation. When dissolved, neutralize with sodium carbonate and pour into drain with at least 50 times its volume of water. |
| 누출 처리 | Personal protection: face shield. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Cautiously neutralize remainder. Then store and dispose of according to local regulations. |
| Preventive Measures | SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.If material not on fire and not involved in fire: Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers.Personnel protection: Avoid breathing dusts, and fumes from burning material. Avoid bodily contact with the material. ... If contact with the material anticipated, wear appropriate chemical protective clothing. |
| 유해 작용 | Dermatotoxin - Skin burns.Toxic Pneumonitis - Inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors. |
| 노출 경로 | The substance can be absorbed into the body by inhalation of its aerosol and by ingestion. |
| Signs and Symptoms | Cough. Sore throat.Redness. Pain.Redness. Pain. Burns. |
| ICSC Environmental Data | The substance is harmful to aquatic organisms. |
| Human Toxicity Excerpts | SYMPTOMATOLOGY (...INGESTION OR SKIN CONTACT): 1. CORROSION OF MUCOUS MEMBRANES OF MOUTH, THROAT...ESOPHAGUS, WITH...PAIN & DYSPHAGIA. NECROTIC AREAS...GRAYISH WHITE BUT SOON...BLACKISH DISCOLORATION...& SOMETIMES SHRUNKEN OR WRINKLED TEXTURE. /ACID/SYMPTOMATOLOGY.../INGESTION/: 2. EPIGASTRIC PAIN...MAY BE ASSOC WITH NAUSEA & VOMITING...INTENSE THIRST. 3. CIRCULATORY COLLAPSE...CLAMMY SKIN, WEAK & RAPID PULSE, SHALLOW RESP...SCANTY URINE. ...SHOCK IS OFTEN...CAUSE OF DEATH. 4. ASPHYXIAL DEATH DUE TO GLOTTIC EDEMA. /ACID/SYMPTOMATOLOGY.../INGESTION/: 5. ULCERATION OF ALL MEMBRANES & TISSUES WITH WHICH ACID COMES IN CONTACT. ULCERATED AREAS OFTEN PERFORATE, LEADING TO MEDIASTINITIS & PERITONITIS. 6. LATE ESOPHAGEAL, GASTRIC & PYLORIC STRICTURES & STENOSIS...MAY REQUIRE...SURGICAL REPAIR, SHOULD BE ANTICIPATED. /ACID/SYMPTOMATOLOGY.../INGESTION/: 6. ...PERMANENT SCARS MAY...APPEAR CORNEA, SKIN & OROPHARYNX. 7. UNCORRECTED CIRCULATORY COLLAPSE OF SEVERAL HR...MAY LEAD TO RENAL FAILURE & ISCHEMIC LESIONS IN LIVER & HEART. /ACID/For more Human Toxicity Excerpts (Complete) data for SULFAMIC ACID (6 total), please visit the HSDB record page. |
| Artificial Pollution Sources | SUBSTANCE WHICH MIGRATES TO FOOD FROM PACKAGING MATERIALS. |
| Non-Human Toxicity Excerpts | ON RABBIT EYES APPLICATION OF 0.5 CC OF 4% SOLN IS REPORTED TO HAVE CAUSED MODERATE CONJUNCTIVITIS & EDEMA, BUT NO SERIOUS INJURY...SOLN PRODUCE IRRITATION ON SC INJECTION IN RATS /AND/ ON THE CONJUNCTIVA OF RABBITS ... .SOMEWHAT MORE TOXIC THAN AMMONIUM SALT /HERBICIDAL FORM/ TO MAMMALS...Circulation and respiration were not greatly influenced after iv injection of 100 mg/kg in rats. |
| 수질 위해 등급(WGK) | 1 |
| TSCA 등재 상태 | TSCA listed |
| RTECS 번호 | WO5950000 |
| 운송 번호(UN) | UN 2967 |
| 독성 | MLD orally in rats: 1.6 g/kg (Ambrose) |
| 관세 코드 | 28111980 |
| 위험 문구(R) | 36/38-52/53 |
| 위험 표시 | Xi |
| 안전 문구(S) | 26-28-61-28A |
| 포장분류 | III |
| 위험 등급 | 8Aquatic Chronic 3Eye Irrit. 2Skin Irrit. 2 |
| 기존화학 물질 | KE-32336 |
| 저장 분류 | 8A - Combustible corrosive hazardous materials |
| 유해 물질 데이터 | 5329-14-6(Hazardous Substances Data) |
용도
용도
표백, 단마제의 원료, 아질산 이온제거제,금소표면의세척,유기합성에 사용.
용도
Sulfamic acid is widely used in electroplating, hard-water scale reremovers, acidic cleaning agent, chlorine stabilizers, sulfonating agents, denitrification agents, disinfectants, flame retardants, herbicides, artificial sweeteners and catalysts.Sulfamic acid is a precursor to sweet-tasting compounds. Reaction with cyclohexylamine followed by addition of NaOH gives C6H11NHSO3Na, sodium cyclamate.Sulfamic acid is a water-soluble, moderately strong acid. An intermediate between sulfuric acid and sulfamide, it can be used as a precursor to sweet-tasting compounds, a therapeutic drug component, an acidic cleaning agent, and a catalyst for esterification.
일반 설명
Sulfamic acid appears as a white crystalline solid. Density 2.1 g / cm3. Melting point 205°C. Combustible. Irritates skin, eyes, and mucous membranes. Low toxicity. Used to make dyes and other chemicals. It is used as a raw material for the preparation of a synthetic sweetener i.e, sodium cyclohexylsulfamate.