테스토스테론
테스토스테론 · Sustanon · TESTOSTERON · Testosterone powder · AndroGel · virilon · Sust · oreton
식별자 및 물리적 특성
| CAS No. | 58-22-0 |
|---|---|
| 분자식 | C19H28O2 |
| 평균 분자량 | 288.4 g/mol |
| 단동위원소 질량 | 288.20893014 g/mol |
| SMILES | C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CC[C@@H]2O |
| InChIKey | MUMGGOZAMZWBJJ-DYKIIFRCSA-N |
| PubChem CID | 6013 |
| ChEMBL | CHEMBL386630 |
| ChEBI | CHEBI:17347 |
| EC No. | 200-370-5 |
| DTXSID | DTXSID8022371 |
| 현지명 | 테스토스테론 |
화학 및 물리적 성질
| XLogP | 3.3 |
|---|---|
| 극성 표면적 | 37.3 |
| 수소 결합 공여자 수 | 1 |
| 수소 결합 수용자 수 | 2 |
| 회전 가능 결합 수 | 0 |
| 무거운 원자 수 | 21 |
| 형식 전하 | 0 |
| 복잡도 | 508 |
| 물질 분류 | Hormone |
| 의약품 | DEA NFLIS-Drug Category -> SteroidsDEA Schedule III Controlled Substance -> Anabolic steroidsPharmaceuticals -> Listed in ZINC15Pharmaceuticals -> Synthetic Cannabinoids or Psychoactive Compounds |
| 지질 | Lipids -> Sterol Lipids [ST] -> Steroids [ST02] -> C19 steroids (androgens) and derivatives [ST0202] |
| SpringerMaterials Properties | Chemical shift |
| LogP(분배 계수) | log Kow = 3.323.13 |
| 냄새 | Odorless |
| Color/Form | White needles from dilute acetoneNeedles from dilute acetoneWhite or slightly cream-white crystals or crystalline powder |
| 용해도 | In water, 23.4 mg/L at 25 °CFreely soluble in dehydrogenated alcohol, chloroformsoluble in vegetable oils, alcohol, dioxane and other organic solventsslightly soluble in etherInsoluble in waterSoluble in ethanol, ethyl ether, acetoneIn ethanol: 1 in 5in chloroform: 1 in 2in diethyl ether: 1 in 100in ethyl oleate: 1 in 150. Sol in acetone, dioxane and fixed oils45%(w/v) aq 2-히드록시프로필-β-시클로덱스트린: 용해성18.2 mg/ml |
| Human Drugs | Breast FeedingLactationMilk, HumanAndrogensHormonesFDA approved drugs -> Active ingredient |
| Animal Drugs | Active Ingredients (Testosterone) -> FDA GreenbookPharmaceuticals -> Animal Drugs -> Approved in Taiwan |
| Endocrine Disruptors | Potential endocrine disrupting compound |
| Decomposition | When heated to decomposition it emits acrid smoke and irritating fumes. |
| 녹는점 | 152-156 °C |
| 끓는 점 | 370.65°C (rough estimate) |
| 밀도 | 1.0484 (rough estimate) |
| 굴절률 | 1.4709 (estimate) |
| 인화점 | 5 °C |
| 저장 조건 | 2-8°C |
| 물리적 상태 | 가루 |
| pKa(산도 계수) | 15.06±0.60(Predicted) |
| 용해도 | 22.79mg/L(20℃) |
| Merck | 13,9255 |
| BRN | 1915399 |
| 헨리 상수 | 2.8×103 mol/(m3Pa) at 25℃, HSDB (2015) |
| 안정성 | 안정적인. 타기 쉬운. 강한 산화제와 호환되지 않습니다. |
| 화장품 원료 기능 | 피부 컨디셔닝 |
| InChI | 1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-17,21H,3-10H2,1-2H3/t14-,15-,16-,17-,18-,19-/m0/s1 |
| InChIKey | MUMGGOZAMZWBJJ-DYKIIFRCSA-N |
| SMILES | C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2O |
| NIST | Testosterone(58-22-0) |
| EPA | Testosterone (58-22-0) |
화학적 성질
white crystalline odourless solid
안전 및 규제
| GHS 분류 | DangerH302 (64.9%): Harmful if swallowed [Warning Acute toxicity, oral]P203, P260, P263, P264, P270, P273, P280, P301+P317, P318, P319, P330, P391, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 231 reports by companies from 17 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.H302: Harmful if swallowed [Warning Acute toxicity, oral] |
|---|---|
| 규제 정보 | Hazard Traits - CarcinogenicityDEA schedule III controlled substanceDirective (EC) No 74/2003Status: Active Update: 22-11-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/25237Testosterone: Does not have an individual approval but may be used under an appropriate group standard |
| 기타 안전 정보 | IMAP assessments - Androst-4-en-3-one, 17-hydroxy-, (17.beta.)-: Human health tier I assessment |
| FDA 요건 | The Approved Drug Products with Therapeutic Equivalence Evaluations identifies currently marketed prescription drug products, including testosterone, approved on the basis of safety and effectiveness by FDA under sections 505 of the Federal Food, Drug, and Cosmetic Act.The Approved Drug Products with Therapeutic Equivalence Evaluations identifies currently marketed prescription drug products, including testosterone cypionate, approved on the basis of safety and effectiveness by FDA under sections 505 of the Federal Food, Drug, and Cosmetic Act. /Testosterone cypionate/The Approved Drug Products with Therapeutic Equivalence Evaluations identifies currently marketed prescription drug products, including testosterone enanthate, approved on the basis of safety and effectiveness by FDA under sections 505 of the Federal Food, Drug, and Cosmetic Act. /Testosterone enanthate/The Approved Drug Products with Therapeutic Equivalence Evaluations identifies currently marketed prescription drug products, including testosterone undecanoate, approved on the basis of safety and effectiveness by FDA under sections 505 of the Federal Food, Drug, and Cosmetic Act. /Testosterone undecanoate/For more FDA Requirements (Complete) data for Testosterone (10 total), please visit the HSDB record page. |
| Toxic Combustion Products | Special hazards arising from the substance or mixture: Carbon oxides. |
용도
개요
Testosterone (Item No.15645) is an analytical reference material categorized as an anabolic androgenic steroid. Testosterone is an endogenous metabolite of androstenedione (Item Nos. ISO60161 | 15874) and estradiol (Item Nos. ISO60155 | 10006315). Anabolic steroids, including testosterone, have been used to enhance physical performance in athletes. Testosterone is regulated as a Schedule III compound in the United States. This product is intended for research and forensic applications.
용도
Secreted by the testis and is converted to dihydrotestosterone in the target tissue where is appears to mediate many of the biological actions of testosterone. CONTROLLED SUBSTANC
일반 설명
Testosterone, 17β-hydroxyandrost-4-en-3-one, is a naturally occurring androgen in men. Inwomen, it mainly serves as a biosynthetic precursor to estradiolbut also has other hormonal effects. It is rapidly metabolizedto relatively inactive 17-ones, however,preventing significant oral activity. Testosterone is availablein a transdermal delivery system (patch), a gel formulation, abuccal system, and as implantable pellets.