Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
프로메타진 수화염화물
프로메타진수화염화물 · PROMETHAZINE HCL · Phena · PHENERGAN · remsed · promine · N,N-Dimethyl-1-(10H-phenothiazin-10-yl)propan-2-amine hydrochloride · dorme
식별자 및 물리적 특성
| CAS No. | 58-33-3 |
|---|---|
| 분자식 | C17H20N2S.ClH |
| 평균 분자량 | 320.9 g/mol |
| 단동위원소 질량 | 320.11139735 g/mol |
| SMILES | CC(CN1c2ccccc2Sc2ccccc21)N(C)C.Cl |
| InChIKey | XXPDBLUZJRXNNZ-UHFFFAOYSA-N |
| PubChem CID | 6014 |
| ChEMBL | CHEMBL1200750 |
| ChEBI | CHEBI:8462 |
| EC No. | 200-375-2 |
| DTXSID | DTXSID3021192 |
| 현지명 | 프로메타진 수화염화물 |
화학 및 물리적 성질
| 극성 표면적 | 31.8 |
|---|---|
| 수소 결합 공여자 수 | 1 |
| 수소 결합 수용자 수 | 3 |
| 회전 가능 결합 수 | 3 |
| 무거운 원자 수 | 21 |
| 형식 전하 | 0 |
| 복잡도 | 298 |
| 용해도 | greater than or equal to 100 mg/mL at 72 °F (NTP, 1992)물에 매우 잘 녹고, 에탄올(96%)과 염화메틸렌에 잘 녹습니다. |
| Human Drugs | Breast FeedingLactationMilk, HumanAntiemeticsAntipruriticsPhenothiazinesFDA approved drugs -> Active ingredient |
| 녹는점 | 446 to 450 °F (decomposes) (NTP, 1992)230-232°C |
| Physical Description | Promethazine hydrochloride is an odorless white to faint yellow crystalline powder. Bitter taste. A 10% solution in water has a pH of 3.5-5.0. (NTP, 1992) |
| Collision Cross Section | 162.7 Ų [M+H]+ [CCS Type: TWMethod: calibrated with polyalanine and drug standards] |
| 인화점 | 9℃ |
| 저장 조건 | 2-8°C |
| 물리적 상태 | Solid |
| 색상 | 흰색에서 거의 흰색 |
| pH | pH (50g/L, 25℃) : 4.0～6.0 |
| 냄새 | Odorless |
| Merck | 14,7786 |
| BRN | 4166397 |
| BCS Class | 1,3 |
| 주요 응용 | 의약품(소분자) |
| InChI | InChI=1S/C17H20N2S.ClH/c1-13(18(2)3)12-19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19/h4-11,13H,12H2,1-3H31H |
| InChIKey | XXPDBLUZJRXNNZ-UHFFFAOYSA-N |
| SMILES | N1(CC(C)N(C)C)C2C=CC=CC=2SC2=CC=CC=C12.Cl |
| EPA | Promethazine hydrochloride (58-33-3) |
화학적 성질
White Solid
안전 및 규제
| GHS 분류 | This chemical does not meet GHS hazard criteria for 0.7% (1 of 142) of reports.DangerH302 (92.3%): Harmful if swallowed [Warning Acute toxicity, oral]P261, P264, P264+P265, P270, P271, P272, P273, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P330, P332+P317, P333+P317, P337+P317, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 142 reports by companies from 19 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| 규제 정보 | 10H-Phenothiazine-10-ethanamine, N,N,.alpha.-trimethyl-, monohydrochloride: Does not have an individual approval but may be used under an appropriate group standard |
| 기타 안전 정보 | IMAP assessments - 10H-Phenothiazine-10-ethanamine, N,N,.alpha.-trimethyl-, monohydrochloride: Environment tier I assessment |
| 화재 위험 | Flash point data for this chemical are not availablehowever, it is probably combustible. (NTP, 1992) |
| 건강 유해성 | SYMPTOMS: Symptoms of exposure to this compound include excitement, sleepiness, convulsions and rigidity. Other symptoms include leukopenia, agranulocytosis, drowsiness, confusion and stupor. Acute transitory myopia may occur. Central nervous system effects may also occur. It may cause an increase in blood pressure, mild hypotension, jaundice, extra-pyramidal reactions and photosensitivity. It may also cause dizziness, central nervous system depression, vomiting, local anesthesia, abdominal pain, diarrhea and dryness of the mouth, throat and nose. Symptoms of exposure to this type of compound include muscular weakness, tachycardia, nausea, sedation, tinnitus, lassitude, incoordination, fatigue, blurred vision, diplopia, euphoria, nervousness, insomnia, tremors, loss of appetite, epigastric distress, constipation, cough, urinary retention or frequency, dysuria, palpitation, headache, tightness of the chest, tingling, heaviness and weakness of the hands, allergic dermatitis, fever, hemolytic anemia (rare), fixed and dilated pupils, and flushing. In children, exposure can cause hallucinations, excitement, ataxia, incoordination, athetosis and convulsions. |
| 반응성 그룹 | Amines, Phosphines, and Pyridines |
| Reactivity Profile | PROMETHAZINE HYDROCHLORIDE is sensitive to light. In aqueous solution, it is degraded by heat and light (more rapidly in air or oxygen). Incompatible with alkalis and alkaline solutions such as those of aminophylline, soluble barbiturates and phenytoin sodium. Iron(III) and copper(III) accelerate the degradation (NTP, 1992). |
| Air and Water Reactions | Slowly oxidizes in air, acquiring a blue color. Also turns blue on exposure to moisture. Water soluble. |
| Hazard Classes and Categories | Acute Tox. 4 (92.3%) |
| 소화 | Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992) |
| 응급 처치 | EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. If symptoms (such as redness or irritation) develop, immediately transport the victim to a hospital. |
| 비화재 누출 대응 | SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. |
| Personal Protective Equipment (PPE) | RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. |
| 노출 경로 | On average, 88% of a promethazine dose is absorbed after oral administrationhowever, the absolute bioavailability is only 25% because of first-pass clearance. |
| 독성 요약 | Like other H1-antagonists, promethazine competes with free histamine for binding at H1-receptor sites in the GI tract, uterus, large blood vessels, and bronchial muscle. The relief of nausea appears to be related to central anticholinergic actions and may implicate activity on the medullary chemoreceptor trigger zone. |
| Signs and Symptoms | Symptoms of overdose include mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). |
| Carcinogen Classification | Promethazine HydrochlorideTR-425: Toxicology and Carcinogenesis Studies of Promethazine Hydrochloride (CASRN 58-33-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies) (1993 )12/01/92No Evidence |
| Drug Induced Liver Injury | Drug Induced Liver Injury Rank (DILIrank 2.0)Promethazine hydrochloridevLess-DILI-concern5Adverse reactionsDOI:10.1016/j.drudis.2016.02.015 |
| Effects During Pregnancy and Lactation | ◉ Summary of Use during Lactation |
| Toxicity Data | IV, Mouse: LD<sub>50</sub>=55mg/kg |
| 수질 위해 등급(WGK) | 3 |
| TSCA 등재 상태 | TSCA listed |
| RTECS 번호 | SO8225000 |
| 운송 번호(UN) | UN 2811 6.1/PG 3 |
| 독성 | LD50 i.v. in mice: 55.0 mg/kg (Rajsner) |
| 관세 코드 | 29343000 |
| 위험 문구(R) | 22-36/37/38-51/53-43-20/22 |
| 위험 표시 | Xn,N |
| 안전 문구(S) | 26-36-61-60-36/37/39-28-22 |
| 포장분류 | III |
| 위험 등급 | 6.1(b)Acute Tox. 4 OralAquatic Chronic 2Eye Dam. 1Skin Sens. 1 |
| 기존화학 물질 | KE-34663 |
| 저장 분류 | 11 - Combustible Solids |
용도
용도
Promethazine hydrochloride is used as antihistamine; antiemetic; central nervous system depressant; sedative; anticholinergic; antiserotoninergic; local anesthetic; in the treatment of motion sickness, cough linctuses, nausea, and allergic conditions; used to control Parkinsonian symptoms and as central nervous system depressant; in pills, syrup, injections and suppositories.
일반 설명
Odorless white to faint yellow crystalline powder. Bitter taste. A 10% solution in water has a pH of 3.5-5.0.