Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
10, 10'-옥시디페녹사르신
펜아르사진옥사이드 · 10,10'-옥시디페녹사르신 · 펜아르사진 옥사이드 · 10,10-옥시다이페녹사르신 · 10,10'-옥시비스-10H-페녹사르신 · 10,10-옥시비스-페녹사르신 · 10,10'-옥시비스페녹시아르신 · 10-페녹사르시닌-10-일옥시페녹사르시닌
식별자 및 물리적 특성
| CAS No. | 58-36-6 |
|---|---|
| 분자식 | C24H16As2O3 |
| 평균 분자량 | 502.2 g/mol |
| 단동위원소 질량 | 501.95313737 g/mol |
| SMILES | c1ccc2c(c1)Oc1ccccc1[As]2O[As]1c2ccccc2Oc2ccccc21 |
| InChIKey | VCRZAKVGPJFABU-UHFFFAOYSA-N |
| PubChem CID | 6017 |
| EC No. | 200-377-3 |
| DTXSID | DTXSID0032443 |
| 현지명 | 10, 10'-옥시디페녹사르신 |
화학 및 물리적 성질
| 극성 표면적 | 27.7 |
|---|---|
| 수소 결합 공여자 수 | 0 |
| 수소 결합 수용자 수 | 3 |
| 회전 가능 결합 수 | 2 |
| 무거운 원자 수 | 29 |
| 형식 전하 | 0 |
| 복잡도 | 482 |
| 물질 분류 | Metals -> Arsenic Compounds, Organic |
| 밀도 | 1.40-1.42 @25 °C |
| 녹는점 | 363 to 365 °F (EPA, 1998)180-184°C |
| 증기압 | 0.00001 [mm Hg] @25 °C |
| Physical Description | Phenoxarsine, 10,10'-oxydi- appears as a clear light yellow liquid with a mild odor. Insoluble in water and slightly denser than water. Contact may severely irritate skin, eyes, and mucous membranes.Colorless solid[Merck Index] White crystalline solid[MSDSonline] |
| 끓는 점 | 232.5°C |
| 저장 조건 | Sealed in dry,Room Temperature |
| 물리적 상태 | 고체 |
| 색상 | 에탄올 또는 2-프로판올에서 결정화 |
| 용해도 | 불용성 |
| InChI | InChI=1S/C24H16As2O3/c1-5-13-21-17(9-1)25(18-10-2-6-14-22(18)27-21)29-26-19-11-3-7-15-23(19)28-24-16-8-4-12-20(24)26/h1-16H |
| InChIKey | VCRZAKVGPJFABU-UHFFFAOYSA-N |
| SMILES | O([As]1C2=CC=CC=C2OC2=C1C=CC=C2)[As]1C2=CC=CC=C2OC2=C1C=CC=C2 |
| EPA | 10,10'-Oxybisphenoxarsine (58-36-6) |
화학적 성질
10-10′-Oxidiphenoxarsine is a colorless crystalline, organometallic solid or a dense yellow liquid. Odorless.
안전 및 규제
| GHS 분류 | DangerH300 (73.4%): Fatal if swallowed [Danger Acute toxicity, oral]P260, P261, P262, P264, P264+P265, P270, P271, P273, P280, P284, P301+P316, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P319, P320, P321, P330, P361+P364, P363, P391, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 94 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| 규제 정보 | Chemical: 10H-Phenoxarsine, 10,10'-oxybis-Restricted substance: Diphenoxarsin-10-yl oxide10H-Phenoxarsine, 10,10'-oxybis-: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.) |
| 운송 라벨(DOT) | Corrosive |
| 화재 위험 | (Non-Specific -- Arsenic Compounds) When heated to decomposition, it emits highly toxic fumes of arsenic. (EPA, 1998) |
| 건강 유해성 | (Non-Specific -- Arsenic Compounds) Arsenic compounds are acutely poisonous by ingestion. Ingestion or inhalation may result in chronic poisoning. Arsenic compounds are recognized carcinogens of the skin, lungs, and liver. (EPA, 1998) |
| 유해성 요약 | Severely irritating to skinToxic by ingestion and inhalationOral LD50 (rat) = 40 mg/kg[Sax] Retards growth and causes liver effects in high-dose feeding studiesNo developmental, reproductive, or mutagenic effectsArsenic accumulates in liver and kidneys of exposed animals with clearing 2 weeks after last exposureThe potential for occupational exposure to OBPA is minimal provided that OBPA is used in a closed system and that appropriate Personal Protective Equipment (PPE) is worn. [EPA REDs] An irritant that can cause skin burnsMay be lethal if ingested or inhaledMay cause liver and kidney damage[MSDSonline] Almost nothing is known regarding health effects of organic arsenic compounds in humans. Studies in animals show that some simple organic arsenic compounds are less toxic than inorganic forms. Ingestion of methyl and dimethyl compounds can cause diarrhea and damage to the kidneys. [ATSDR ToxProfiles] |
| 반응성 그룹 | Ethers |
| Reactivity Alerts | Highly Flammable |
| Reactivity Profile | Organometallics, such as PHENOXARSINE, 10,10'-OXYDI-, are reactive with many other groups. Incompatible with acids and bases. Organometallics are good reducing agents and therefore incompatible with oxidizing agents. |
| Air and Water Reactions | Highly flammable. Insoluble in water. |
| Hazard Classes and Categories | Acute Tox. 2 (73.4%) |
| 소화 | (Non-Specific -- Arsenic Compound, Solid, n.o.s.) Stay upwindkeep out of low areas. Wear self-contained (positive pressure if available) breathing apparatus and full protective clothing. |
| 응급 처치 | Warning: Effects usually appear within 30 to 60 minutes, but may be delayed for a few hours. Arsenic compounds are recognized carcinogens of the skin, lungs, and liver. Caution is advised. |
| 비화재 누출 대응 | Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]: |
| Isolation and Evacuation | Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]: |
| Minimum Risk Level | Acute Oral: 0.005 mg/kg/day (L134) Chronic Oral: 0.0003 mg/kg/day (L134) Chronic Inhalation: 0.01 mg/m3 (L134) |
| Permissible Exposure Limit (PEL) | 0.5 [mg/m3], as As |
| Protective Action Criteria (PAC) | 1.3 [mg/m3]14 [mg/m3]84 [mg/m3] |
| Personal Protective Equipment (PPE) | For emergency situations, wear a positive pressure, pressure-demand, full facepiece self-contained breathing apparatus (SCBA) or pressure- demand supplied air respirator with escape SCBA and a fully-encapsulating, chemical resistant suit. (EPA, 1998) |
| Treatment | Arsenic poisoning can be treated by chelation therapy, using chelating agents such as dimercaprol, EDTA or DMSA. Charcoal tablets may also be used for less severe cases. In addition, maintaining a diet high in sulfur helps eliminate arsenic from the body. (L20) |
| 건강 영향 | Arsenic poisoning can lead to death from multi-system organ failure, probably from necrotic cell death, not apoptosis. Arsenic is also a known carcinogen, esepcially in skin, liver, bladder and lung cancers. (T1, L20) |
| 유해 작용 | Dermatotoxin - Skin burns. |
| 노출 경로 | Oral (L2)inhalation (L2)dermal (L2) |
| 독성 요약 | Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by competing with phosphate it uncouples oxidative phosphorylation, thus inhibiting energy-linked reduction of NAD+, mitochondrial respiration, and ATP synthesis. Hydrogen peroxide production is also increased, which might form reactive oxygen species and oxidative stress. Arsenic's carginogenicity is influenced by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. The binding of other arsenic protein targets may also cause altered DNA repair enzyme activity, altered DNA methylation patterns and cell proliferation. (T1, A17) |
| Signs and Symptoms | Exposure to lower levels of arsenic can cause nausea and vomiting, decreased production of red and white blood cells, abnormal heart rhythm, damage to blood vessels, and a sensation of |
| Carcinogen Classification | 3, not classifiable as to its carcinogenicity to humans. (L135) |
| Toxicity Data | LCLo (guinea pigs) = 141 mg/m3/2hLD50: 40 mg/kg (Oral, Rat) (T14) |
| 운송 번호(UN) | 1557 |
| 독성 | LD50 orl-rat: 40 mg/kg TXCYAC 10,341,78 |
| 포장분류 | II |
| 위험 등급 | 6.1(a) |
| 기존화학 물질 | KE-12054 |
| 유해 물질 데이터 | 58-36-6(Hazardous Substances Data) |
| 함량 및 규제정보 | 물질구분: 유독물질혼합물(제품)함량정보: 비소 또는 그 화합물과 비소화합물을 0.1% 이상 함유한 혼합물 |
| 유해화학물질 필터링 | 97-1-119 |
| 중점관리물질 필터링 | 별표1-6 |
용도
일반 설명
A clear light yellow liquid with a mild odor. Insoluble in water and slightly denser than water. Contact may severely irritate skin, eyes, and mucous membranes. Flash point 98°F.