Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
에틸렌디아민테트라아세트산, 이나트륨 염
에틸렌디아민테트라아세트산,이나트륨염 · 에틸렌디아민테트라아세트산 · 다이소듐이디티에이 · EDTA-2NA · DISODIUM EDTA · DISODIUM EDETATE · ETA · EDETATE DISODIUM
식별자 및 물리적 특성
| CAS No. | 139-33-3 |
|---|---|
| 분자식 | C10H16N2O8 |
| 평균 분자량 | 292.24 g/mol |
| 단동위원소 질량 | 292.09066547 g/mol |
| SMILES | O=C(O)CN(CCN(CC(=O)O)CC(=O)O)CC(=O)O |
| InChIKey | KCXVZYZYPLLWCC-UHFFFAOYSA-N |
| PubChem CID | 6049 |
| ChEMBL | CHEMBL858 |
| ChEBI | CHEBI:4735 |
| EC No. | 200-449-4 |
| DTXSID | DTXSID6022977 |
| 현지명 | 에틸렌디아민테트라아세트산, 이나트륨 염 |
화학 및 물리적 성질
| XLogP | -5.9 |
|---|---|
| 극성 표면적 | 156 |
| 수소 결합 공여자 수 | 4 |
| 수소 결합 수용자 수 | 10 |
| 회전 가능 결합 수 | 11 |
| 무거운 원자 수 | 20 |
| 형식 전하 | 0 |
| 복잡도 | 315 |
| LogP(분배 계수) | -2.6-3.34 (calculated) |
| 밀도 | 0.86 at 68 °F (USCG, 1999) - Less dense than waterwill floatRelative density (water = 1): 0.861.01 g/mL at 25 °C |
| Color/Form | Crystals from waterColorless crystalsWhite crystalline powder |
| 용해도 | 1000000SOL IN SOLN OF ALKALI HYDROXIDESInsoluble in common organic solventsIn water, 1,000 mg/L at 25 °C9.26e+00 g/LSolubility in water, g/100ml at 20 °C: 0.05 (very poor)H2O: 투명, 무색 |
| 인화점 | Flash point is> 100 °C, |
| Decomposition | When heated to decomp it emits toxic fume of /nitrogen oxides/.Disodium EDTA decomposes at 252 °C.When heated to decomposition it emits toxic fumes of /nitrogen oxides and sodium oxides/.220-245 °C |
| 녹는점 | 237245 °CMP: 240-241 °C (decomposes). The free acid tends to carboxylate when heated to temps of 150 °C. Stable on storage and on boiling in aqueous solution.MP: 242 °C /EDTA disodium dihydrate/248 °C (dec.)(lit.) |
| 증기압 | 1.50X10-12 mm Hg at 25 °C /Extrapolated/0Pa at 25℃ |
| Physical Description | Ethylenediamine tetraacetic acid is a colorless crystalline solid. It is slightly soluble in water. The primary hazard is the threat to the environment. Immediate steps should be taken to limit its spread to the environment. It is used in chemical analysis, to make detergents and cleaning compounds, and for many other uses.CBIOther SolidDry PowderLiquidLarge CrystalsClear crystals[CAMEO]White odorless solid[JECFA] White odorless crystals[Mallinckrodt Baker MSDS] |
| Stability/Shelf Life | Generally, EDTA is stable as a solid and in aqueous solution. Only strong oxidizing agents can attack it chemically. The stability of EDTA-metal chelates increases according to the order: Na+ <Ca2+ < Fe2+ < Co2+ <Zn2+ < Cu2+ < Pb2+ < Fe3+EDTA is less stable than its salts and tends to decarboxylate when heated to 150 °C. It is stable when stored and when boiled in aqueous solution. |
| Dissociation Constants | pKa = 0.26 |
| Collision Cross Section | 151.17 Ų [M-H]- [CCS Type: DTMethod: single field calibrated with Agilent tune mix (Agilent)]159.6 Ų [M+H]+ [CCS Type: DT |
| 끓는 점 | >100 °C |
| 굴절률 | n20/D 1.363 |
| 저장 조건 | 2-8°C |
| 물리적 상태 | 액체 |
| 색상 | ≤5 (0.5 M)(APHA) |
| pH | 8.0±0.2 |
| 냄새 | 100.00%. 냄새 없는 |
| 용해도 | 물과 섞일 수 있습니다. |
| BRN | 3822669 |
| 안정성 | 흡습성 |
| 화장품 원료 기능 | 킬레이팅점도 조절 |
| InChI | 1S/C10H16N2O8.2Na/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20)/q2*+1/p-2 |
| InChIKey | ZGTMUACCHSMWAC-UHFFFAOYSA-L |
| SMILES | [Na+].[Na+].OC(=O)CN(CCN(CC(O)=O)CC([O-])=O)CC([O-])=O |
| LogP(분배 계수) | -4.3 at 25℃ |
| EPA | Ethylenediaminetetraacetic acid disodium salt (139-33-3) |
| Absorption | cut-off at 268nm |
화학적 성질
Disodium edetate occurs as a white crystalline, odorless powder with a slightly acidic taste.
안전 및 규제
| GHS 분류 | WarningH319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]P264+P265, P280, P305+P351+P338, and P337+P317 (click each P-code to see the statement)This chemical does not meet GHS hazard criteria for 0.4% (6 of 1452) of reports. |
|---|---|
| 규제 정보 | Chemical: Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-Chemical: Glycine, N,Nâ²-1,2-ethanediylbis[N-(carboxymethyl)-, sodium salt (1:2)Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-, sodium salt (1:2) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-, sodium salt (1:2) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 14-04-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/14698Status: Active Update: 25-02-2016 https://echa.europa.eu/registration-dossier/-/registered-dossier/7894Disodium EDTA: Does not have an individual approval but may be used under an appropriate group standard |
| 기타 안전 정보 | IMAP assessments - Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-, disodium salt: Human health tier I assessmentIMAP assessments - Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-: Human health tier I assessment |
| 화재 위험 | Combustible. Gives off irritating or toxic fumes (or gases) in a fire. Finely dispersed particles form explosive mixtures in air. |
| 유해성 요약 | Can cause burns to skin and eyes[CAMEO] Potential skin sensitizer[HSDB] Has reproductive toxicity in animal studiesMay cause kidney damage after chronic exposureA skin and eye irritant[MSDSonline] See Tetrasodium EDTA.Causes convulsions in oral lethal-dose studies of ratsCauses other changes of the liver and kidney in 30-day intermittent oral studies of rabbits[RTECS] Acceptable daily intake (ADI) of 0-2.5 mg/kg[JECFA] A mild irritant[Mallinckrodt Baker MSDS] See Edetic acid. |
| FDA 요건 | The Approved Drug Products with Therapeutic Equivalence Evaluations identifies discontinued drug products. Edetate disodium is included on this list. |
| 반응성 그룹 | Acids, CarboxylicAmines, Phosphines, and Pyridines |
| Special Reports | Hart JRCosmet Toiletries 98 (4): 54-8 (1983)use of EDTA-type chelating agents and their salts in shampoos, liquid soaps, skin cleaners, creams and lotions, and other products are reviewed.NTP TR No 011Route: oral in feedSpecies: rats and mice. NTIS No PB270938/AS. /Trisodium ethylenediaminetetraacetate trihydrate/[NTPDivision of Toxicology Research and TestingManagement Status Report07/07/93p.28] |
| FIFRA 요건 | As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their continued use. Under this pesticide reregistration program, EPA examines newer health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether the use of the pesticide does not pose unreasonable risk in accordance to newer saftey standards, such as those described in the Food Quality Protection Act of 1996. Pesticides for which EPA had not issued Registration Standards prior to the effective date of FIFRA '88 were divided into three lists based upon their potential for human exposure and other factors, with List B containing pesticides of greater concern than those on List C, and with List C containing pesticides of greater concern than those on List D. Ethylenediaminetetraacetic acid is found on List D. Case No: 4036Pesticide type: insecticide fungicide, herbicide, antimicrobialCase Status: None of the active ingredients in the case are being supported for reregistration by their registrants. All are unsupported, or some are unsupported and some are cancelled. Cases described as "unsupported" generally are being processed for cancellation.Active ingredient (AI): ethylenediaminetetraacetic acidAI Status: The active ingredient is no longer contained in any registered products ... "cancelled."Residues of the following chemical substances are exempted from the requirement of a tolerance when used in accordance with good manufacturing practice as ingredients in an antimicrobial pesticide formulation, provided that the substance is applied on a semi-permanent or permanent food-contact surface (other than being applied on food packaging) with adequate draining before contact with food. ... (b) The following chemical substances when used as ingredients in an antimicrobial pesticide formulation may be applied to: Dairy processing equipment, and food-processing equipment and utensils. Ethylenediaminetetraacetic acid (EDTA), disodium salt is included on this list. Limit: When ready for use, the end-use concentration is not to exceed 1400 ppm.Residues of the following chemical substances are exempted from the requirement of a tolerance when used in accordance with good manufacturing practice as ingredients in an antimicrobial pesticide formulation, provided that the substance is applied on a semi-permanent or permanent food-contact surface (other than being applied on food packaging) with adequate draining before contact with food. ... (c) The following chemical substances when used as ingredients in an antimicrobial pesticide formulation may be applied to: Food-processing equipment and utensils. Ethylenediaminetetraacetic acid (EDTA), disodium salt is included on this list. Limit: When ready for use, the end-use concentration is not to exceed 1400 ppm.As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their continued use. Under this pesticide reregistration program, EPA examines newer health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether the use of the pesticide does not pose unreasonable risk in accordance to newer saftey standards, such as those described in the Food Quality Protection Act of 1996. Pesticides for which EPA had not issued Registration Standards prior to the effective date of FIFRA '88 were divided into three lists based upon their potential for human exposure and other factors, with List B containing pesticides of greater concern than those on List C, and with List C containing pesticides of greater concern than those on List D. Ethylenediaminetetraacetic acid, disodium salt is found on List D. Case No: 4036Pesticide type: insecticide, fungicide, herbicide, antimicrobialActive ingredient (AI): Ethylenediaminetetraacetic acid, disodium salt |
| Reactivity Profile | Behaves as a weak organic acid. Carboxylic acids donate hydrogen ions if a base is present to accept them. They react in this way with all bases, both organic (for example, the amines) and inorganic. Their reactions with bases, called "neutralizations", are accompanied by the evolution of substantial amounts of heat. Neutralization between an acid and a base produces water plus a salt. Carboxylic acids with six or fewer carbon atoms are freely or moderately soluble in waterthose with more than six carbons are slightly soluble in water. Soluble carboxylic acid dissociate to an extent in water to yield hydrogen ions. The pH of solutions of carboxylic acids is therefore less than 7.0. Many insoluble carboxylic acids react rapidly with aqueous solutions containing a chemical base and dissolve as the neutralization generates a soluble salt. Carboxylic acids in aqueous solution and liquid or molten carboxylic acids can react with active metals to form gaseous hydrogen and a metal salt. Such reactions occur in principle for solid carboxylic acids as well, but are slow if the solid acid remains dry. Even "insoluble" carboxylic acids may absorb enough water from the air and dissolve sufficiently in it to corrode or dissolve iron, steel, and aluminum parts and containers. Carboxylic acids, like other acids, react with cyanide salts to generate gaseous hydrogen cyanide. The reaction is slower for dry, solid carboxylic acids. Insoluble carboxylic acids react with solutions of cyanides to cause the release of gaseous hydrogen cyanide. Flammable and/or toxic gases and heat are generated by the reaction of carboxylic acids with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides. Carboxylic acids, especially in aqueous solution, also react with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat. Their reaction with carbonates and bicarbonates generates a harmless gas (carbon |
| Chemical Dangers | Decomposes on heating. This produces toxic fumes of nitrous oxides. Reacts with strong oxidants. Attacks some forms of metals and rubber. |
| Physical Dangers | Dust explosion possible if in powder or granular form, mixed with air. |
| History and Incidents | The Food and Drug Administration (FDA) is withdrawing approval of one new drug application (NDA) and two abbreviated new drug applications (ANDAs) for edetate disodium injection. The holders of these applications have agreed in writing to permit FDA to withdraw approval of the applications and have waived their opportunity for a hearing. ... Edetate disodium is indicated for the treatment of hypercalcemia and for the control of ventricular arrhythmias associated with digitalis toxicity. Hospira, Inc. (Hospira), Apotex Inc. (Apotex), and Bioniche Pharma (Bioniche) have agreed in writing to permit FDA to withdraw approval of their respective applications (listed in the table of this document), and to voluntarily remove their respective products from the market, under part 314.150(d) (21 CFR 314.150(d)). On January 16, 2008, FDA issued a public health advisory to alert patients and healthcare professionals about important safety information concerning the drug edetate disodium (see ''FDA Public Health Advisory: Edetate Disodium (Marketed as ENDRATE and Generic Products), ... As noted in the January 16, 2008, Public Health Advisory, there have been cases where children and adults have died when they were mistakenly given edetate disodium instead of edetate calcium disodium (calcium disodium versenate) or when edetate disodium was used for indications other than those approved by FDA./OTHER TOXICITY INFORMATION/ Fatal medication errors have occurred that involve confusion between edetate calcium disodium (calcium EDTA) and edetate disodium (no longer commercially available in the US). Children and adults have mistakenly received edetate disodium instead of edetate calcium disodiumat least 5 deaths have occurred as a result of inadvertent administration of edetate disodium. Although both edetate calcium disodium and edetate disodium are heavy metal antagonists, the 2 drugs were originally approved by the US Food and Drug Administration (FDA) for different uses and have different effectsedetate disodium was formerly FDA approved for use in selected patients for the emergency treatment of hypercalcemia or for the control of ventricular arrhythmias associated with cardiac glycoside toxicity. Use of edetate disodium may result in a substantial, and sometimes fatal, decrease in serum calcium concentrations. In June 2008, FDA withdrew its prior approval for edetate disodium because of safety concerns following a review of the risk-benefit profile of the drug. FDA stated that it was not considering additional action regarding edetate calcium disodium at that timemost of the fatalities following administration of an EDTA drug have involved medication errors in which edetate disodium was administered instead of edetate calcium disodium. FDA has not received reports of any fatalities resulting from the administration of edetate calcium disodium that involve a medication error. |
| 소화 | Use water spray, foam, carbon dioxide, powder. |
| 응급 조치 | Fresh air, rest.Rinse skin with plenty of water or shower.Rinse with plenty of water (remove contact lenses if easily possible).Rinse mouth. Give one or two glasses of water to drink. |
| 안전 보관 | Separated from strong oxidants, metals and food and feedstuffs. |
| 소화 절차 | This chemical is a combustible solid. It does not easily ignite. Use dry chemical, carbon dioxide, water spray, or alcohol or polymer foam extinguishers. ...If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use "alcohol" foam, dry chemical or carbon dioxide.Water spray, dry chemical, carbon dioxide, or foam as appropriate for surrounding fire and materials.This material is assumed to be combustible. As with all dry powders, it is advisable to ground mechanical equipment in contact with dry material to dissipate the potential buildup of static electricity. |
| 보관 조건 | Chelating agents, by their very nature, tend to be corrosive to metals such as copper, zinc, and iron. The alkaline salts corrode aluminum severely, and contact with these salts should be avoided. Stainless steel and most polymers or coatings that are able to withstand dilute alkali are acceptable as construction materials. Solid chelating agents should be stored in a cool, dry place to avoid caking. /Chelating agents/Store at 25 °C (77 °F) with excursions permitted between 15 to 30 °C (59 to 86 °F).Store in tight container as defined in the USP-NF. This material should be handled and stored per label instructions to ensure product integrity. Store in a refrigerator. |
| 정리 방법 | Environmental considerations: Land spill: Dig a pit, pond, lagoon, holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Dike surface flow using soil, sand bags, foamed polyurethane, or foamed concrete. Absorb bulk liquid with fly ash or cement powder. Neutralize with sodium bisulfate (NaHSO4).Environmental considerations: Air spill: Apply water spray or mist to knock down vapors. Vapor knockdown water is corrosive or toxic and should be diked for containment.Environmental considerations: Water spill: Use natural barriers or oil spill control booms to limit spill travel. Use surface active agent (e.g., detergent, soaps, alcohols), if approved by EPA. Inject "universal" gelling agent to solidify encircled spill and increase effectiveness of booms. Add sodium bisulfate (NaHSO4). If dissolved, in region of 10 ppm or greater concentration, apply activated carbon at ten times the spilled amount. Use mechanical dredges or lifts to remove immobilized masses of pollutants and precipitates.Wear approved respiratory protection, chemically compatible gloves, and protective clothing. Wipe up spillage or collect spillage using a high-efficiency vacuum cleaner. Avoid breathing dust. Place spillage in appropriately labeled container for disposal. Wash spill site. |
| 처리 방법 | SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air qualitypotential migration in soil or watereffects on animal, aquatic, and plant lifeand conformance with environmental and public health regulations.SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air qualityeffects on animal and plant life |
| 누출 처리 | Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into covered non-metallic containers. Carefully collect remainder. Then store and dispose of according to local regulations. |
| Preventive Measures | SRP: The scientific literature for the use of contact lenses by industrial workers is inconsistent. The benefits or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.Personnel protection: Avoid breathing vapors. Keep upwind. Avoid bodily contact with the material. ... Do not handle broken packages unless wearing appropriate personal protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water. ... If contact with the material anticipated, wear appropriate chemical protective clothing.If material not on fire and not involved in fire: Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. build dikes to contain flow as necessary.As with all fires, evacuate personnel to a safe area. Firefighters should use self-contained breathing equipment and protective clothing.As a general rule, when handling USP Reference Standards avoid all contact and inhalation of dust, mists, and/or vapors associated with the material. Wash thoroughly after handling./Wear/ chemically compatible gloves /and/ safety glasses or goggles. Protect exposed skin. |
| Eye Prevention | Wear safety goggles. |
| Fire Prevention | NO open flames. Prevent deposition of dust. Closed system, dust explosion-proof electrical equipment and lighting. |
| Inhalation Risk | A nuisance-causing concentration of airborne particles can be reached quickly. |
| 상호 작용 | Total myocardial calcium content of rats treated with adriamycin was very high. Treatment with EDTA decreased calcium levels almost to normal valueshowever the histological adriamycin-induced cardiac alterations were not prevented.The effect of EDTA (ethylenediaminetetraacetate) on the antimicrobial activity of 10% sodium sulfacetamide solutions was evaluated in this study by kill rate and minimum /inhibitory/ concentration (mic). EDTA improves the kill rate, but not the mic, for the pseudomonas, serratia, and candida species regardless of the preservative.... Increased absorption of drugs ... occurs in presence of ... ethylenediaminetetraacetic acid (EDTA). When given orally ... (100-500 mg/kg in rats), the chelator increased ... /the/ rate of absorption of heparin, sulfopolyglucin, mannitol, inulin, decamethonium, sulfanilic acid ... Phenol red, all lipid-insoluble substances which ordinarily are poorly absorbed from GI tract. The wide variety of the chemical structures of these suggests that the chelating agent is acting in a nonspecific way and is not affecting the physical or chemical state of the compounds within the intestine ... /there is/ direct evidence that EDTA acts by increasing the permeability of the intestinal epithelium ... Perhaps EDTA alters permeability by increasing the size of the membrane pores or by widening the spaces between the epithelial cells through the removal of calcium ions.The effects of EDTA on contractile responses of hamster cremaster arterioles and rat aortic strips to epinephrine (EPI) or norepinephrine (NOR) were examined. Comparable contractile responses were elicited by lower EPI or NOR concentration in presence than in absence of EDTA. Individual responses were maintained in the presence of EDTA but rapidly declined if EDTA was not present. Apparently, oxidation of EPI and NOR reduces apparent vascular reactivity and EDTA prevents or delays the reduction.For more Interactions (Complete) data for ETHYLENEDIAMINE TETRAACETIC ACID (8 total), please visit the HSDB record page./Investigators/ reported that Disodium EDTA (10 mg/mL) increased the intestinal absorption of neutral, basic, and acidic compounds in the male Sprague-Dawley rat. The chelating agent increased the absorption of (14)C-mannitol and (14)C-inulin from <2% to 7%-b 1%, the absorption of (14)C-N-methyldecamethonium from 2%-3% to 11%-15%, and the absorption of sulfanilic acid from 11%-14% to 26%-32%. Plasma concentrations of the drugs were increased as much as five- or sixfold, compared to controls. |
| 생태독성 수치 | LC50Species: Daphnia magna (Water flea)Conditions: staticConcentration: 625 mg/L for 24 hr /formulated product/Species: Lepomis macrochirus (Bluegill)Conditions: static, pH 3.7Concentration: 159 mg/L for 96 hr96 hr No Observed Effect Concentration: 100 mg/LSpecies: Lepomis macrochirus (Bluegill) weight 0.74 (0.62-1.28) g, length 34 (28-38) mmConcentration: 41 mg/L for 96 hr (95% confidence interval: 34-62 mg/L) /99.33 % a.i., Versene Acid/Species: Ictalurus punctatus (Channel catfish) fingerling, length 2-3 inConcentration: >500 mg/L for 1, 2 hrstatic /Versene acid/For more Ecotoxicity Values (Complete) data for ETHYLENEDIAMINE TETRAACETIC ACID (10 total), please visit the HSDB record page. |
| 환경 거동 | TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 313(SRC), determined from a structure estimation method(2), indicates that ethylenediamine tetraacetic acid is expected to have moderate mobility in soil(SRC). The pKa of ethylenediamine tetraacetic acid is 0.26(3), indicating that this compound will exist almost entirely in anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4). Volatilization of ethylenediamine tetraacetic acid from moist soil surfaces is not expected to be an important fate process(SRC) given its pKa(3). Ethylenediamine tetraacetic acid is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 1.5X10-12 mm Hg at 25 °C(4). A 0% of theoretical BOD using activated sludge in the Japanese MITI test(5) suggests that biodegradation is not important in soil(SRC).AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 313(SRC), determined from a structure estimation method(2), indicates that ethylenediamine tetraacetic acid is expected to adsorb to suspended solids and sediment(SRC). A pKa of 0.26(3) indicates ethylenediamine tetraacetic acid will exist almost entirely in the anion form at pH values of 5 to 9 and therefore volatilization from water surfaces is not expected to be an important fate process(SRC). According to a classification scheme(4), an estimated BCF of 3(SRC), from an estimated log Kow of -3.86(5) and a regression-derived equation(6), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Ethylenediamine tetraacetic acid was poorly biodegraded anaerobically(7). Photodegradation half-lives of ethylenediamine tetraacetic acid in lake water at pH 3.1 and 6.5 are reported as 31.1 and 56.8 minutes, respectively(8). Ethylenediamine tetraacetic acid is not expected to undergo hydrolysis in the environment due to lack of functional groups that hydrolyze under environmental conditions(9).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), ethylenediamine tetraacetic acid, which has a vapor pressure of 1.5X10-12 mm Hg at 25 °C(2), is expected to exist solely in the particulate phase in the ambient atmosphere. Particulate-phase ethylenediamine tetraacetic acid may be removed from the air by wet or dry deposition(SRC). |
| 유해 작용 | Dermatotoxin - Skin burns.There are multiple adverse effects related to the use of EDTA. These side effects are dependent on various factors, including dosage, renal function, and frequency of administration. The most commonly recognized adverse effect is renal toxicity. The toxic effects can manifest as acute tubular necrosis, renal failure, anuria, and proteinuria. Both intramuscular and intravenous routes of administration were shown to increase blood urea nitrogen in more than 25% of patients.Additionally, calcium EDTA has a strong affinity for zinc, which can lead to a zinc deficiency. The amount of zinc lost from the body was shown to be negatively correlated with weight. A study assessing the efficacy of calcium disodium edetate found that smaller children were losing a larger proportion of zinc than larger children. The study further reinforced the need to monitor levels of zinc during chelation therapy.Other side effects include fever, nausea, vomiting, chills, fatigue, arthralgia, hypotension, arrhythmias, acute tubular necrosis, proteinuria, tremors, headache, cheilosis, bone marrow depression, anemia, and hypercalcemia. Pain at the injection site is a common adverse drug reaction of intramuscular administration.Administration of edetate calcium disodium must be carefully distinguished from the administration of edetate disodium. Edetate disodium is similar in structure to edetate calcium disodiumhowever, it is not complexed with calcium. This minor difference protects serum levels of calcium and avoids life-threatening hypocalcemia. Cases have been reported where patients who were incorrectly given edetate disodium had seizures and cardiac arrest. |
| 노출 경로 | The substance can be absorbed into the body by inhalation of dust, by inhalation of its aerosol and by ingestion.Poorly absorbed from the gastrointestinal tract. Well absorbed following intramuscular injection. |
| 독성 요약 | Safe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.orgCurrently, no antidotes are available for EDTA. In patients who have cerebral edema, increases in intracranial pressure should be treated immediately with osmotic agents. Patients with nephrotoxicity should be given fluids to ensure hydration and be monitored for urine output. Renal function should be continuously monitored even after the development of toxicity. Overall, patients who develop signs or symptoms of toxicity should immediately be discontinued from the drug.The pharmacologic effects of edetate calcium disodium are due to the formation of chelates with divalent and trivalent metals. A stable chelate will form with any metal that has the ability to displace calcium from the molecule, a feature shared by lead, zinc, cadmium, manganese, iron and mercury. The amounts of manganese and iron metabolized are not significant. Copper is not mobilized and mercury is unavailable for chelation because it is too tightly bound to body ligands or it is stored in inaccessible body compartments. The excretion of calcium by the body is not increased following intravenous administration of edetate calcium disodium, but the excretion of zinc is considerably increased. |
| Average Daily Intake | The average daily intake of ethylenediamine tetraacetic acid for a man who drinks two liters of water per day would be a maximum of 50 ug. The acceptable daily intake for man is 0 to 2.5 mg/kg(1). |
| 생태독성 발췌 | /AQUATIC SPECIES/ The effect of the strong metal-complexing agent EDTA on survival, growth, and copper and zinc concentrations in Hyalella azteca (scud) was studied to determine if metal concentrations in control amphipods represent minimum physiological levels. Exposure to EDTA concentrations of up to 560 uM for 1 week did not reduce metal levels (mean background = 1.2 umol Cu/g and 1.0 umol Zn/g dry weight), indicating that background metals are firmly bound to Hyalella. Chronic (4 week) exposure to EDTA resulted in increased mortality and reduced growth rates, both of which could be partially ameliorated by adding zinc to culture media. .../AQUATIC SPECIES/ Unicellular alga, poterioochromonas malhamensis, was exposed to inorganic lead or triethyl lead and simultaneously treated with lead antidotes. Some of the antidotes alone slightly to severely inhibited algal growth (bal, EDTA, and salts)./AQUATIC SPECIES/ .../The investigators/ evaluated the effect of a series of factors that could potentially modify metal speciation on the toxicity of Hg, Cu, Zn, and Cd toward a recombinant strain of the freshwater cyanobacterium Anabaena sp. PCC 7120 with cloned lux operon of luminescent terrestrial bacterium Photorhabdus luminescens. The strain, denoted as Anabaena CPB4337, showed a high constitutive luminescence with no need to add exogenous aldehyde. The tested factors were pH, EDTA (as organic ligand), and anions PO(4)(3-), CO(3)(2-), and Cl(-). Chemical modeling and correlation analyses were used to predict metal speciation and link it with toxicity. In general, metal toxicity significantly correlated to the predicted metal free-ion concentration, although Zn-EDTA complexes and certain Hg chloro-complexes could also exhibit some toxicity to cyanobacteria. An interesting feature of metal toxicity to strain Anabaena CPB4337 was that low amounts of PO(4)(3-) and CO(3)(2-) increased metal toxicitythis effect could not be related to significant changes in metal speciation and could be attributed to a modulating effect of these anions on metal/uptake toxicity. The combination of toxicity studies that take into account a range of factors that might modulate metal toxicity with chemical modeling to predict changes in metal speciation might be useful for interpreting complex toxicity data. Finally, this cyanobacterial bioreporter, due to its ecological relevance as a primary producer, could be used as a tool for toxicity assessment in freshwater environments./AQUATIC SPECIES/ ...Standard toxicity bioassays (semi-static, chronic) /were used/ to evaluate EDTA as a chelating agent for reducing trivalent and hexavalent chromium toxicity on Petrolisthes laevigatus. Crab survival decreased linearly with increased chromium concentrations and dropped significantly beginning at 40 mg/L Cr (VI) and 80 mg/L Cr (III). No significant differences were observed with Cr (III) + EDTA as compared with untreated controls. Cr (VI) toxicity was greater than that of Cr (III), with low individual survival rates. The protective effect of EDTA in the medium increased crab survival by 41%-48%./PLANTS/ The effects of Pb chelater (EDTA-Pb) and ionic Pb (Pb(NO(3))(2)) on root cell death, Pb accumulation, changes of ROS, activities of antioxidant enzymes and uptake of mineral elements in response to Pb toxicity in Sedum alfredii H. were compared. Loss of plasma membrane integrity became serious by increasing Pb concentration in the medium, 200 uM Pb + 200 uM EDTA has alleviated the root cell death. The biomass was significantly affected by high concentration of Pb, and root growth was also affected by EDTA-Pb compared with ionic Pb. Lead accumulation was higher in the samples treated with ionic lead than that of the control. The concentration of reactive oxygen species (ROS) was determined by fluorescence microscopy, which indicates that the Pb stress increased the content of ROS significantly, whereas the EDTA-Pb decreased the burst of H(2)O(2). High Pb concentrations increase the activity of /superoxide dismutase/ (SOD) and /lipoxygenase/ (LOX). The Cu concentration in root increased significantly under Pb and EDTA-Pb treatment, and 200 uM Pb markedly increased the Fe content in roots. Under ionic Pb condition, the contents of Mg, Ca and K in shoots decreased, whereas they were significantly increased in case of EDTA-Pb. These results suggested that accumulating ecotype of S. alfredii roots were inefficient in uptake of higher concentration of EDTA-chelated Pb for long treatment duration, and that lead toxicity could be alleviated by EDTA. |
| Signs and Symptoms | Cough.Redness. Pain.Abdominal pain. Diarrhoea. |
| Ongoing Test Status | The following link will take the user to the National Toxicology Program (NTP) Test Agent Search Results page, which tabulates all of the "Standard Toxicology & Carcinogenesis Studies", "Developmental Studies", and "Genetic Toxicity Studies" performed with this chemical. Clicking on the "Testing Status" link will take the user to the status (i.e., in review, in progress, in preparation, on test, completed, etc.) and results of all the studies that the NTP has done on this chemical. /Trisodium ethylenediaminetetraacetate trihydrate/[Available from: http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm?fuseaction=ntpsearch.searchresults&searchterm=150-38-9] |
| Effluent Concentrations | Ethylenediamine tetraacetic acid was identified in the effluent from the Rye Meads, England sewage treatment plant at concentrations ranging from 200 ppb to 1200 ppb in samples taken in 1974(1). The concentration of ethylenediamine tetraacetic acid waste water effluents of five Finnish pulp and paper mills was between 0.24 mg/L and 8.4 mg/L(2). |
| Soil Adsorption/Mobility | Using a structure estimation method based on molecular connectivity indices(1), the Koc of ethylenediamine tetraacetic acid can be estimated to be 313(SRC). According to a classification scheme(2), this estimated Koc value suggests that ethylenediamine tetraacetic acid is expected to have moderate mobility in soil. The pKa of ethylenediamine tetraacetic acid is 0.26(3), indicating that this compound will almost entirely exist in anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4). Ethylenediamine tetraacetic acid adsorption onto lake sediment was 9, 8.6, 24.8, 21.3, 15.4 and 6.3% when complexed with sodium, copper, iron III, mercury, manganese and nickle, respectively(5). The fraction of ethylenediamine tetraacetic acid absorbed onto sediment in samples of surface waters, ground waters, and waste water treatment plant effluents from Switzerland was an average of one percent(6). |
| CERCLA 보고 수량 | Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 5000 lb or 2270 kg. The toll free number of the NRC is (800) 424-8802. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b). |
| 청정수법 요건 | Ethylenediamine tetraacetic acid is designated as a hazardous substance under section 311(b)(2)(A) of the Federal Water Pollution Control Act and further regulated by the Clean Water Act Amendments of 1977 and 1978. These regulations apply to discharges of this substance. This designation includes any isomers and hydrates, as well as any solutions and mixtures containing this substance. |
| 수질 위해 등급(WGK) | 2 |
| TSCA 등재 상태 | TSCA listed |
| RTECS 번호 | AH4410000 |
| 독성 | mouse,LD50,intraperitoneal,260mg/kg (260mg/kg),Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 52, Pg. 126S, 1956. |
| 관세 코드 | 29224999 |
| 위험 문구(R) | 36/38-36/37/38-22-34-21/22 |
| 위험 표시 | Xn,C |
| 안전 문구(S) | 26-36-37/39-45-36/37/39-36/37 |
| 기존화학 물질 | KE-13651 |
| 저장 분류 | 12 - Non Combustible Liquids |
| 유해 물질 데이터 | 139-33-3(Hazardous Substances Data) |
용도
용도
비누 / 세제 : 칼슘 및 마그네슘 비누 형성의 예방; 비누와 세제의 세제를 개선합니다. 과 붕산염과과 탄산염 표백제를 안정화시킵니다. 화학 세척 : 옥살산 칼슘, 황산 칼슘, 탄산 칼슘, 황산 바륨, 및 공정 설비로부터의 다른 타입의 스케일을 제거한다. I & I 청소기 : 스케일을 용해 스케일 형성을 방지, 계면 활성제의 세정력을 향상시킨다. 농축 된 액체 세제 및 샴푸의 탁도를 방지합니다. 유제, 윤활제 및 광택제에 대한 다가 금속 이온의 효과를 최소화합니다. 금속 마감 : 금속 제품의 산화막의 제거; 알칼리성 파쇄; 침산 조의 정전기 방지제; 알칼리 탈지. 섬유가 : 정련에 금속 이온을 제어, 종기 오프, 표백, 염색, 제거하고 작업을 마무리합니다. 형광 증 백제를 금속 촉매 산화 및 분해로부터 보호합니다. 염료의 변색을 방지합니다. 펄프 / 종이 : 수력 표백제의 효율성을 향상; 금속 촉매 밝기 복귀를 감소시킵니다. 스케일 제거 공정 장비에 사용됩니다. 염료가 금속으로 침전되는 것을 방지합니다.
용도
Ethylenediaminetetraacetic acid disodium salt is widely used in textile industry. Usually applied to dissolve limescale. It is applied in textile industry, pulp and paper industry and also in chelation therapy. In cosmetics, it acts as a sequestering agent. It acts as a corrosion inhibitor to carbon steel in the industries. It also acts as a food additive.
일반 설명
Ethylenediamine tetraacetate (EDTA) is a calcium ion chelator, that has a low molecular mass of 292.24 Da.
제조 및 합성 방법
생산 방법
Disodium edetate may be prepared by the reaction of edetic acid and sodium hydroxide.