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Amphetamine Sulfate

HCID 6055
노트반응
기본 정보개요이름 및 식별자물성안전 및 규제화학 및 산업관련 반응화합물 노트
부분 구조 검색유사 구조 찾기

기본 정보

CAS
51-63-8
표준 SMILES
CC(N)Cc1ccccc1.CC(N)Cc1ccccc1.O=S(=O)(O)O
InChIKey
PYHRZPFZZDCOPH-UHFFFAOYSA-N
분자식
C18H28N2O4S
평균 분자량
368.5 g/mol
단동위원소 질량
368.17697855

개요

Amphetamine sulfate is a white crystalline powder. Solution in water has a pH of 5-6. Odorless. Slightly bitter taste followed by a sensation of numbness. May be sensitive to light.

이름 및 식별자

우선 이름
Amphetamine Sulfate
IUPAC
bis(1-phenylpropan-2-amine);sulfuric acid

이름 및 동의어

DL-Amphetamine sulfateAmphetamine sulphatePhenaminumAstedinAmphamine sulfateAmphetamini sulfasBenzpropamineAdiparthrolEuphodineFenedrinIbiozedrinePsychoton
이름 더 보기
SimpaminaAlentolBenniedl-Phenamine sulfatePhenamine sulfatedl-Amphetamine sulphateAmphetaminium sulfuricumBenzedrine sulfate

데이터베이스 식별자

CAS
51-63-8、60-13-9
PubChem CID
6055
DTXSID
DTXSID4020082
ChEMBL
CHEMBL501
ChEBI
CHEBI:51063
UNII
6DPV8NK46S
EC Number
200-457-8

물성

구조 계산 물성

극성 표면적
135 Ų
수소 결합 공여자 수
4
수소 결합 수용자 수
6
회전 가능 결합 수
4
무거운 원자 수
25
형식 전하
0
복잡도
166

실험 및 물리화학적 성질

Density1.15 at 77 °F (NTP, 1992) - Denser than water; will sink
Solubility50 to 100 mg/mL at 61 °F (NTP, 1992)
Human Drugs · 2건

FDA approved drugs -> Active ingredient

FDA approved drugs -> Active ingredient

Melting Point536 to 538 °F (NTP, 1992)
Physical DescriptionAmphetamine sulfate is a white crystalline powder. Solution in water has a pH of 5-6. Odorless. Slightly bitter taste followed by a sensation of numbness. May be sensitive to light.

안전 및 규제

안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.

GHS 분류

GHS Classification · 6건

Danger

H300 (97.9%): Fatal if swallowed [Danger Acute toxicity, oral]

P264, P270, P301+P316, P321, P330, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 48 reports by companies from 5 notifications to the ECHA C&L Inventory.

Danger

H301 (97.6%): Toxic if swallowed [Danger Acute toxicity, oral]

유해성 정보

Regulatory InformationDextroamphetamine sulphate: Does not have an individual approval but may be used under an appropriate group standard
Other Safety InformationIMAP assessments - Benzeneethanamine, .alpha.-methyl-, (S)-, sulfate (2:1): Environment tier I assessment
DOT LabelPoison
Fire HazardsFlash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)
Health Hazards · 1건

SYMPTOMS: Exposure to this compound may cause vasoconstriction, inhibition of motility of the gastrointestinal tract and bladder, dilation of the pupils, increased motor activity and mental alertness, euphoria, diminished sense of fatigue, increased wakefulness, insomnia, headache, hyperexcitability, and cardiac and gastrointestinal disturbances. Large doses may be followed by fatigue and mental depression, rise in blood pressure and mental concentration effects. Excessive use may lead to tolerance and physical dependence.

Reactive GroupHydrocarbons, Aromatic
Reactivity ProfileIncompatible with alkalis and calcium salts. (NTP, 1992). A weak acid.

화학 및 산업

약리 정보

FDA Pharmacological Classification · 4건

AMPHETAMINE SULFATE

Central Nervous System Stimulant [EPC]; Central Nervous System Stimulation [PE]

AMPHETAMINE SULFATE TABLETS

Central Nervous System Stimulant [EPC]; Central Nervous System Stimulation [PE]

MeSH Pharmacological Classification · 6건

A loosely defined group of drugs that tend to increase behavioral alertness, agitation, or excitation. They work by a variety of mechanisms, but usually not by direct excitation of neurons. The many drugs that have such actions as side effects to their main therapeutic use are not included here.

Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters.

Any drugs that are used for their effects on dopamine receptors, on the life cycle of dopamine, or on the survival of dopaminergic neurons.

Drugs that act on adrenergic receptors or affect the life cycle of adrenergic transmitters. Included here are adrenergic agonists and antagonists and agents that affect the synthesis, storage, uptake, metabolism, or release of adrenergic transmitters.

Drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants (ANTIDEPRESSIVE AGENTS, TRICYCLIC) and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin.

Drugs that block the transport of DOPAMINE into axon terminals or into storage vesicles within terminals. Most of the ADRENERGIC UPTAKE INHIBITORS also inhibit dopamine uptake.

관련 반응

0건
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화합물 노트

불러오는 중…

이 페이지에서기본 정보개요이름 및 식별자물성안전 및 규제화학 및 산업관련 반응화합물 노트
Air and Water Reactions
Water soluble. Hygroscopic.
Hazard Classes and Categories · 2건

Acute Tox. 2 (97.9%)

Acute Tox. 3 (97.6%)

안전 및 보호

Fire FightingFires involving this compound should be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)
First Aid · 1건

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Nonfire Spill Response · 1건

SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

Isolation and EvacuationExcerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:
Personal Protective Equipment (PPE) · 1건

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter). (NTP, 1992)

독성 정보

Carcinogen Classification · 6건

dl-Amphetamine Sulfate

TR-387: Toxicology and Carcinogenesis Studies of dl-Amphetamine Sulfate (CASRN 60-13-9) in F344/N Rats and B6C3F1 Mice (Feed Studies) (1991 )

04/25/90

No Evidence

No Evidence

No Evidence

Drug Induced Liver Injury · 6건

Drug Induced Liver Injury Rank (DILIrank 2.0)

Amphetamine sulfate

vLess-DILI-concern

0

No match

DOI:10.1016/j.drudis.2016.02.015

EPA Human Health Benchmarks for Pharmaceuticals · 6건

Amphetamine sulfate

0.1

0.5

Usual dose is 5 to 60 milligrams per day in divided doses depending on the individual patient response.

Data used to generate the benchmarks include the following: Lowest Daily Dose (LDD): 5 mg/day, Lowest Therapeutic Dose (LTD): 0.1 mg/kg-day, and Screening Dose: 0.00002 mg/kg-day.

27-Dec-21