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기본 정보
- CAS
129655-21-6- 표준 SMILES
Cc1c[nH]c2c(O)cc3c(c12)[C@H](CCl)CN3C(=O)c1cc2cc(NC(=O)Nc3ccc4[nH]c(C(=O)N5C[C@@H](CCl)c6c5cc(O)c5[nH]cc(C)c65)cc4c3)ccc2[nH]1- InChIKey
FONKWHRXTPJODV-DNQXCXABSA-N- 분자식
- C43H36Cl2N8O5
- 평균 분자량
- 815.718 g/mol
- 단동위원소 질량
- 814.21857161
이름 및 식별자
- 우선 이름
- Bizelesin
- IUPAC
- N,N'-Bis{2-[(1S)-1-(chloromethyl)-5-hydroxy-8-methyl-1,6-dihydropyrrolo[3,2-e]indole-3(2H)-carbonyl]-1H-indol-5-yl}urea
- 현지명
- 비즐레신
- 영어명
- Bizelesin
- 분자식
- C43H36Cl2N8O5
- 분자량
- 815.7
이름 및 동의어
비즐레신U-77779BizelesinNSC-615291(8S,8'S)-6,6'-[Carbonylbis(iMino-1H- indole-5,2-diylcarbonyl)]bis[8-(chloroMethyl)-3,6,7,8-tetrahydro-1-Methylbe1,3-bis[2-[(8S)-8-(chloromethyl)-4-hydroxy-1-methyl-7,8-dihydro-3H-pyrrolo[3,2-e]indole-6-carbonyl]-1H-indol-5-yl]ureaN,N'-Bis[2-[[(1S)-1-(chloroMethyl)-1,6-dihydro-5-hydroxy-8-Methylbenzo[1,2-b:4,3-b']dipyrrol-3(2H)-yl]carbonyl]-1H-indol-5-yl]ureaUrea, N,N'-bis[2-[[(1S)-1-(chloromethyl)-1,6-dihydro-5-hydroxy-8-methylbenzo[1,2-b:4,3-b']dipyrrol-3(2H)-yl]carbonyl]-1H-indol-5-yl]-1,3-Bis[2-[[[(8S)-8β-chloromethyl-3,6,7,8-tetrahydro-4-hydroxy-1-methylbenzo[1,2-b:4,3-b']dipyrrol]-6-yl]carbonyl]-1H-indol-5-yl]urea
데이터베이스 식별자
- CAS
129655-21-6- PubChem CID
- 60794
- DTXSID
DTXSID00156213- ChEMBL
CHEMBL284642- UNII
- L0O9OBI87E
- Nikkaji
- J449.250A
물성
물리화학적 성질
- 밀도
- 1.604 · 1.604±0.06 g/cm3(Predicted)
- 산도 계수 (pKa)
- 10.06 · 10.06±0.40(Predicted)
- 물리적 상태
- Solid
- 색상
- Off-white to yellow
화학 및 산업
응용 분야
용도As members of the cyclopropylpyrroloindole family, Adozelesin and Bizelesin cause genomic DNA lesions by alkylating DNA. Adozelesin induces single-strand DNA lesions, whereas Bizelesin induces both si ngle-strand lesions and double-strand DNA cross-links. liferation by different pathways (i.e., Adozelesin induced apoptosis, and Bizelesin induced senescence).
공급사12 곳
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